Anticancer - Hormonal Agents

Question 1

What are the Glucorticoids

Answer 1

Dexamethasone
Hydrocortisone
Prednisone
Prednisolone

Question 2

What are the Estrogens

Answer 2

Diethylstilbestrol

Ethinyl estradiol

Question 3

What are the Estrogen Inhibitors

Answer 3

Tamoxifen
Raloxifen
Aminoglutethimide
Anastrazole
Letrozole
Exemestane
Formestane

Question 4

What are the Progestins

Answer 4

Hydroxyprogesterone

Megestrol

Question 5

What are the Androgens

Answer 5

Fluoxymesterone

Testosterone

Question 6

What are the Anti-androgens

Answer 6

Leuprolide
Goserelin
Flutamide

Question 7

Used in palliative care to improve feeling of well-being

Answer 7

Glucocorticoids

Question 8

When are the Estrogens contraindicated

Answer 8

Breast CA

Ovarian CA

Question 9

How do Glucocorticoids and Estrogens work

Answer 9

Bind cytoplasmic receptor

Modulate gene expression

Question 10

When are Glucocorticoids given

Answer 10

ALL
Hodgkin's Lymphoma
Edema in spinal cord compression
Autoimmune anemia
Thrombocytopenia

Question 11

What are the Glucocorticoid AE

Answer 11

Immunosuppression
Poor wound healing
Osteoporosis
Hyperglycemia
Mood swings

Question 12

What are Estrogens given for

Answer 12

Prostate CA

Question 13

What are the Estrogen AE

Answer 13

Thromboembolism
Migraine
Cholestasis
Mood changes
Gynecomastia and Impotence

Question 14

Where does Tamoxifen work

Answer 14

Antagonist at Breast

Agonist on Endometrium and Bone

Question 15

Where does Raloxifen work

Answer 15

Antagonist at Breast, Endometrium and Bone

Question 16

What do Tamoxifen and Raloxifen inhibit

Answer 16

Estrogen receptor

Question 17

When do you give Tamoxifen

Answer 17

Metastatic Breast CA

Decrease incidence of Breast CA in high risk women

Question 18

What are the AE of Estrogen Receptor blockers

Answer 18

Hot flush
Thrombosis
Fluid retention
Increased risk of Endometrial CA

Question 19

What are the Aromatase inhibitors

Answer 19

Aminoglutethimide
Anastrazole
Letrozole
Exemestane
Formestane

Question 20

What else does Aminoglutethimide block

Answer 20

Adrenal and Extra-adrenal steroid synthesis

Question 21

When do you give Aminoglutethimide

Answer 21

ER+ Metastatic Breast CA

Question 22

Which Aromatase Inhibitors are Steroids

Answer 22

Aminoglutethimide
Exemestane
Formestane

Question 23

Which Aromatase Inhibitors are Non-steroidal

Answer 23

Anastrazole

Letrozole

Question 24

What do you give for ER+ Metastatic Breast CA that is resistant to Tamoxifen

Answer 24

Exemestane
Formestane
Anastrazole
Letrozole

Question 25

What causes a hot flush and headache

Answer 25

Exemestane | Formestane

Question 26

What causes Mood changes, acne and hair growth

Answer 26

Anastrazole | Letrozole

Question 27

Which of the Aromatase inhibitors are Irreversible

Answer 27

Anastrazole | Letrozole

Question 28

Palliative care to improve appetite and feeling of well-being in terminal pts

Answer 28

Hydroxyprogesterone Megestrol Fluoxymesterone Testosterone

Question 29

What do you give Progestins for

Answer 29

Endometrial CA

Question 30

What are the Progestin AE

Answer 30

``` Weight gain Depression Edema Acne Decreased HDL ```

Question 31

A continuous dose can cause medical castration (Decreased FSH/LH)

Answer 31

Leuprolide | Goserelin

Question 32

GnRH analogs (supress steroidogenesis)

Answer 32

Leuprolide | Goserelin

Question 33

When do you give GnRH analogs

Answer 33

Prostate CA | Uterine fibroids

Question 34

What are the GnRH analog AE

Answer 34

Initial flare up of androgen dependent CA Decrease bone mass Hot flush Impotence and Gynecomastia

Question 35

What do you give GnRH analogs with

Answer 35

Flutamide

Question 36

What does Flutamide do

Answer 36

Inhibit initial tumor flare-up

Question 37

How does Flutamide work

Answer 37

Inhibit androgen uptake/binding to target tissue

Question 38

When do you give Flutamide

Answer 38

Prostate CA