Anticancer - General Info Flashcards Preview

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Flashcards in Anticancer - General Info Deck (24):
1

What is the Log-kill hypothesis

Fixed fraction of tumor cells killed during chemo

2

What kind of drugs work on cells in G0

Cell cycle non-specific drugs

3

How do you maximize tumor killing

Use drugs with different MOA and known efficacies

4

How do you minimize lethal damage

Drugs with different side effects

5

What cells are most commonly affected by chemo

Rapidly dividing

6

How do prevent resistance

Drugs affecting different parts of cell cycle
Drugs with different MOAs

7

What mutation confers MTX resistance

DHF reductase

8

What is MDR mediated by

P-glycoprotein

9

Where does Bleomycin act

G2

10

What is the Bleomycin toxicity

Pulmonary Fibrosis

11

Where does Vincristine act

M

12

What is the Vincristine toxicity

Neurotoxic

13

Where do Doxorubicin and Dacarbazine act

G0

14

What is the Doxorubicin toxicity

Cardiotoxic

15

What is the Dacarbazine toxicity

BM toxicity

16

What is the BEP regimen for Testicular Cancer

Bleomycin
Etoposide
Platinum compounds (Cisplatin)

17

Where does Etoposide act

Late S
Early G2

18

What is the Etoposide toxicity

BM toxicity

19

Where does Cisplatin act

G0

20

What are the Cisplatin toxicities

Nephrotoxicity
Ototoxixity

21

Adjuvant therapy

Chemo along with surgery or radiation

22

Neo-adjuvant therapy

Chemo before surgery

23

Induction chemo

Chemo for complete remission (blood cancers)

24

Maintenance chemo

Chemo to maintain remission