Anticancer - Misc Flashcards Preview

Pharm Midterm 2 > Anticancer - Misc > Flashcards

Flashcards in Anticancer - Misc Deck (18):
1

What are the Misc Anticancer agents

Hydroxyurea
L-Asparaginase
Arsenic trioxide
Interferon

2

Where does Hydroxyurea work

S

3

Urea analog

Hydroxyurea

4

What does Hydroxyurea do

Inhibit ribonucleotide reductase
Decrease DNA synth

5

When do you give Hydroxyurea

Melanoma
CML
Increase HbF in Sickle Cell

6

What are the Hydroxyurea AE

Reversible Leukopenia
GI tox
Mild derm changes

7

When does L-Asparaginase act

G1

8

How does L-Asparaginase work

Hydrolyze Asparagine to Aspartate and Ammonia
Inhibition of protein synthesis

9

When do you give L-Asparaginase

Acute Leukemia in children

10

What are the main L-Asparaginase AE

Hemorrhage
Pancreatitis

11

What are the other L-Asparaginase AE

HS
Hyperglycemia
HA

12

When do you give Arsenic trioxide

AML that's PML-, RARalpha+

13

What does Arsenic trioxide do

Induce differentiation and apoptosis of leukemic cells

14

What are the Arsenic trioxide AE

HA
Arrhythmia
Fluid retention
Increased risk for skin CA

15

What does Interferon do

Stimulate NK by increasing HLA expression on tumor

16

What do you give IFN-2alpha for

CML
Hairy Cell Leukemia
Kaposi's Sarcoma

17

What do you give IFN-2beta for

Melanoma
Follicular Lymphoma

18

What are the Interferon AE

Fever, myalgia, HA
Loss of appetite
Depression