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Flashcards in Cephalosporins Deck (26):
1

Cephalosporin action

Bind PBPs
Activate Autolysin

2

What are Cephalosporins inactive against

Listeria, Legionella
Atypical (Chlamydia, Mycoplasma), Acinetobacter
MRSA
Enterococci

3

Oral Cephalosporins

Cephalexin
Cefaclor
Cefixime

4

Effect of cephalosporin combination with aminoglycosides

Increase aminoglycoside nephrotoxicity

5

Which cephalosporins can cause hypoprothrombinemia and disulfiram-like reaction

Cefamandole
Cefoperazone
Cefotetan

6

What happens when you go from 1st-3rd gen

Decrease G+ activity
Increase G- activity

7

Efficacy of 4th gen

G+ and G-

8

1st gen

Cefazolin
Cephalexin

9

What do you give 1st gen for

Proteus
E. coli
Klebsiella

10

What are 1st gen resistant to

Staph penicillinase

11

DOC G+ surgical prophylaxis

Cephazolin

12

2nd gen

Cefaclor
Cefoxitin
Cefotetan
Cefamandole

13

What are 2nd gen for

H. influenza
Enterobacter
Nisseria
Proteus
E. coli
Klebsiella

14

Use of 2nd gen

When PCN can't be used
Sinusitis, otitis, lower RTI

15

Prophylaxis/Tx for G- abd/pelvic infections

Cefotetan
Cefoxitin

16

3rd gen

Ceftriaxone
Cefoperazone
Cefotaxime
Ceftazidime
Cefixime

17

What are 3rd gen used for

H. Influenza
Enterobacteriaceae
Nisseria

18

Pneumococcal infections

Cefotaxime
Ceftriaxone

19

Ceftriaxone is DOC for

N. gonorrhea
Meningitis (amp res H. influenzae)
Lyme disease w/ CNS and joint

20

Meningitis prophylaxis

Ceftriaxone
Ciprofloxacin
Rifampin

21

Lyme disease w/o CNS and joint

Doxycycline

22

P. aeruginosa

Cefoperazone
Ceftazidime

23

4th gen

Cefepime

24

Cefapime administration

IV

25

Empiric for serious infection

Cefepime

26

What can you give Cefepime for

Haemophillus
Neisseria
E. coli
Pneumococci
P. mirabilis
P. aeruginosa