Anticancer - Natural Products Flashcards Preview

Pharm Midterm 2 > Anticancer - Natural Products > Flashcards

Flashcards in Anticancer - Natural Products Deck (25):
1

What are the Vinca Alkaloids

Vincristine
Vinblastine
Vinorelbine

2

What are the Taxanes

Paclitaxel
Docetaxel

3

What are the Epipodophyllotoxins

Etoposide
Teniposide

4

What are the Camptothecins

Tropotecan
Irinotecan

5

How do the Vinca Alkaloids work

Bind tubulin
Prevent MT formation (no spindle)
Arrest in M

6

What is Vincristine given for

Hodgkin's

7

What is Vinblastine given for

Testicular CA

8

What is Vinorelbine given for

NSCLC

9

Vincristine AE

Neuropathy (BM sparing)

10

Vinblastine AE

Myelosuppression

11

Vinorelbine AE

Granulocytopenia

12

How do the Taxanes work

Enhance and Stabilize MT formation
Arrest in M

13

What are the Taxanes given for

Ovarian and Breast CA

14

Paclitaxel AE

Severe allergy
Neutropenia
Alopecia

15

Docetaxel AE

Skin toxicity
Fluid retention

16

When do the Epipodophyllotoxins act

Late S, Early G2

17

How do Epipodophyllotoxins work

Topo II inhibitor
Prevent re-ligation

18

What are the Epipodophyllotoxins for

Germ cell tumor
AML
Lung CA

19

What are the Epipodophyllotoxins AE

Myelosuppression
Leukemia

20

When is Irinotecan toxicity seen

Gilbert's Syndrome

21

How do the Camptothecins work

Topo I inhibition

22

What is Topotecan used for

Ovarian CA mets

23

What is Irinotecan used for

Colorectal CA

24

Topotecan AE

Pancytopenia

25

Irinotecan AE

Diarrhea
Myelosuppression