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Pharm Midterm 2 > Penicillins > Flashcards

Flashcards in Penicillins Deck (38):
1

What are the Beta Lactams

Penicillins
Cephalosporins
Carbapenems
Monobactams

2

How do Penicillins work

Bactericidal
Bind PBPs inhibiting cell wall synthesis

3

What does PCN activate

Autolysin

4

Where do Penicillins not work

Prostate
Eye
Brain (except meningitis)

5

Where are Penicillins excreted

Kidney

6

Where is Naficillin excreted

Bile
Use for renal insufficiency

7

What is excreted in renal and bile

Oxacillin
Dicloxacillin

8

What can be given synergistically with PCN

Aminoglycoside

9

What is DOC for empiric infective endocarditis

PCN G + Gentamycin

10

Is there cross allergy reactivity between beta lactams

Yes

11

Which PCN can cause interstitial nephritis

Methicilin

12

What is seen in interstitial nephritis

Oliguria
Fever, rash
EOS in urine

13

Which PCN can cause pseudomembranous colitis

Ampicillin

14

How do penicillins cause a maculopapular rash

Ampicillin/Amoxicillin for viral infection

15

Which PCN can cause elevated BT

Ticarcillin
Inhibits platelet function

16

Which PCN can cause neutropenia

Nafcillin

17

Which PCN can cause hepatitis

Oxacillin

18

What are the 4 mechanisms of PCN resistance

Inactivated by Beta-lactamase
Modified PBPs
Impaired penetration
Increased efflux

19

What resistance mechanism does MRSA/ORSA have

Altered PBPs

20

What are the "Natural" Penicillins

Penicillin G
Penicillin G benzathine
Penicillin G procaine

21

DOC strep throat

Penicillin V

22

DOC P. Aeruginosa

Ticarcillin
Carbenicillin
Piperacillin

23

What does Penicillin G act on

Gram+ Except staph
Gram- cocci
Anaerobes
Strep
Pneumococci

24

DOC Syphillis

Penicillin G

25

Which PCN is susceptible to beta lactamase

G
V
TCP
Amox/Ampi

26

Amox/Ampi URTs

H. influenza
S. pneumoniae

27

Amox/Ampi UTIs

E. coli

28

Amox/Ampi misc enterococci

P. mirabilis
Salmonella
Shigella

29

Which PCN Gs are IM

Benzathine
Procaine

30

Which Penicillin has highest f

Amoxicillin

31

Are Amox/Ampi ok in pregnancy

Yes

32

When is Amoxicillin given

Endocarditis prophylaxis in dental/resp procedures

33

What do you give for Listeria and enterococci

Ampicillin with aminoglycoside

34

Which PCN is never used clinically

Methicillin (causes AIN)

35

DOC Staph endocarditis w/o prosthetic valve

Methicillin
Nafcillin
Oxacillin
Dicloxacillin

36

What is the infection most likely with prosthetic valve

S. viridans

37

Amox/Ampi spectrum

Extended

38

What are the beta-lactamase inhibitors

Clavulanic acid
Sulbactam
Tazobactam