Penicillins

Question 1

What are the Beta Lactams

Answer 1

Penicillins
Cephalosporins
Carbapenems
Monobactams

Question 2

How do Penicillins work

Answer 2

Bactericidal

Bind PBPs inhibiting cell wall synthesis

Question 3

What does PCN activate

Answer 3

Autolysin

Question 4

Where do Penicillins not work

Answer 4

Prostate
Eye
Brain (except meningitis)

Question 5

Where are Penicillins excreted

Answer 5

Kidney

Question 6

Where is Naficillin excreted

Answer 6

Bile

Use for renal insufficiency

Question 7

What is excreted in renal and bile

Answer 7

Oxacillin

Dicloxacillin

Question 8

What can be given synergistically with PCN

Answer 8

Aminoglycoside

Question 9

What is DOC for empiric infective endocarditis

Answer 9

PCN G + Gentamycin

Question 10

Is there cross allergy reactivity between beta lactams

Answer 10

Yes

Question 11

Which PCN can cause interstitial nephritis

Answer 11

Methicilin

Question 12

What is seen in interstitial nephritis

Answer 12

Oliguria
Fever, rash
EOS in urine

Question 13

Which PCN can cause pseudomembranous colitis

Answer 13

Ampicillin

Question 14

How do penicillins cause a maculopapular rash

Answer 14

Ampicillin/Amoxicillin for viral infection

Question 15

Which PCN can cause elevated BT

Answer 15

Ticarcillin

Inhibits platelet function

Question 16

Which PCN can cause neutropenia

Answer 16

Nafcillin

Question 17

Which PCN can cause hepatitis

Answer 17

Oxacillin

Question 18

What are the 4 mechanisms of PCN resistance

Answer 18

Inactivated by Beta-lactamase
Modified PBPs
Impaired penetration
Increased efflux

Question 19

What resistance mechanism does MRSA/ORSA have

Answer 19

Altered PBPs

Question 20

What are the “Natural” Penicillins

Answer 20

Penicillin G
Penicillin G benzathine
Penicillin G procaine

Question 21

DOC strep throat

Answer 21

Penicillin V

Question 22

DOC P. Aeruginosa

Answer 22

Ticarcillin
Carbenicillin
Piperacillin

Question 23

What does Penicillin G act on

Answer 23

Gram+ Except staph
Gram- cocci
Anaerobes
Strep
Pneumococci

Question 24

DOC Syphillis

Answer 24

Penicillin G

Question 25

Which PCN is susceptible to beta lactamase

Answer 25

G V TCP Amox/Ampi

Question 26

Amox/Ampi URTs

Answer 26

H. influenza | S. pneumoniae

Question 27

Amox/Ampi UTIs

Answer 27

E. coli

Question 28

Amox/Ampi misc enterococci

Answer 28

P. mirabilis Salmonella Shigella

Question 29

Which PCN Gs are IM

Answer 29

Benzathine | Procaine

Question 30

Which Penicillin has highest f

Answer 30

Amoxicillin

Question 31

Are Amox/Ampi ok in pregnancy

Answer 31

Yes

Question 32

When is Amoxicillin given

Answer 32

Endocarditis prophylaxis in dental/resp procedures

Question 33

What do you give for Listeria and enterococci

Answer 33

Ampicillin with aminoglycoside

Question 34

Which PCN is never used clinically

Answer 34

Methicillin (causes AIN)

Question 35

DOC Staph endocarditis w/o prosthetic valve

Answer 35

Methicillin Nafcillin Oxacillin Dicloxacillin

Question 36

What is the infection most likely with prosthetic valve

Answer 36

S. viridans

Question 37

Amox/Ampi spectrum

Answer 37

Extended

Question 38

What are the beta-lactamase inhibitors

Answer 38

Clavulanic acid Sulbactam Tazobactam