Flashcards in Nutrition Deficiencies Deck (83)
Vit B5 Deficiency
Dermatitis, enteritis, alopecia, adrenal insufficiency
What is B6 converted into?
Vit B6 Function
- Cofactor: transamination (ALT, AST), decarboxylation rxns, glycogen phosphorylase
- Synthesis: cystathionine, heme, niacin, HA, and NT (5HT, Epi, NE, DA, GABA)
Vit B6 Deficiency
Convulsions, hyperirritability, peripheral neuropathy
What kind of anemia can B6 deficiency cause?
Sideroblastic anemia due to impaired Hb synthesis and iron excess
- Nucleated erythrocytes
MCC of B6 deficiency?
- isoniazid therapy for TB
Function of B7?
Cofactor for carboxylation E
- Pyruvate carboxylase: pyruvate (3C) --> oxaloacetate (4C) [gluconeogenesis]
- Acetyl-CoA Carboxylase: acetyl-CoA (2C) --> malonyl-CoA (3C) [FA synthesis]
- Propionyl-CoA carboxylase: propionyl-CoA (3C) --> methylmalonyl-CoA (4C) [metabolism of odd chain FA]
Carboxylase enzymes require what 3 things?
- ATP, biotin, CO2
Dermatitis, alopecia, enteritis
Causes of B7 deficiency?
- Excessive ingestion of raw egg whites (avidin)
- E involved in recycling biotin
- Presents the same as biotin deficiency
- Newborns screened
- Leafy green vegetables
- Converted to tetrahydrofolic acid --> 1-carbon transfer/methylation
- Synthesis of nitrogenous bases in DNA & RNA
Where is B9 absorbed?
Small reserve in liver
Blood findings on B9 deficiency?
- Macrocytic megaloblastic anemia
- Hypersegmented PMNs
B9 deficiency sx?
- NO NEURO SX
B9 deficiency labs?
Normal methylmalonic acid
Who gets B9 deficient?
- most common vit deficiency in U.S.
- Drugs (phenytoin, sulfonamides, MTX)
Vit B12 Function
- Animal products
- Methionine synthase (transfers CH3 groups as methylcobalamin)
- Methylmalonyl-CoA mutae (odd #C FA metaboilsm)
Who needs B12 supplement?
Who needs B9 supplement?
very large pool in liver (several years)
B12 deficiency caused by?
- Malabsorption (sprue, enteritis, Diphyllobothrium latum)
- Lack of IF (pernicious anemia [anti-IF Ab], gastric bypass surgery)
- Absence of terminal ileum (surgical resection - Crohn DZ)
- Insufficient intake (veganism)
- Long term omeprazole use
B12 deficiency sx?
- Macrocytic, megaloblastic anemia
- Hypersegmented PMNs
- Subacute combined degeneration
- Prolonged deficiency --> irreversible nerve damage
Subacute combined degeneration?
- Dorsal columns
- Lateral corticospinal trats
- Spinocerebellar tracts