Opioid Flashcards Preview

Unit 4 > Opioid > Flashcards

Flashcards in Opioid Deck (26)
1

What are the 3 opioid receptors?

Mu/kappa/delta

2

What protein is mu receptor coupled with and where do you find these receptors?

Gi coupled
Pre and post synaptic

3

How does stimulating mu receptor decrease pain?

Stimulate presynaptic mu--->decrease Ca influx--->decrease substance P (pain transmitter)
Stimulate postsynaptic mu--->increase K efflux--->membrane hyperpolarization

4

What are the Gi coupled presynaptic and post synaptic receptors besisdes mu?

Presynaptic--->MAD2
Postsynaptic--->M2

5

What is the analgesia effect?

Increase pain tolerance and decrease perception and reaction to pain

6

What is the mechanism of morphine and what are its effect? what drug is used for overdose?

Mu agonist
Analgesia/sedation
Respiratory depression--->decrease response to increase CO2
Naloxone--->mu blocker

7

Morphine cause vasodilation or vasoconstriction? and what should we be cautious about giving morphine to head trauma pt?

Morphine--->histamine release--->vasodilation
Vasodilation might cause increase intracranial pressure

8

What are the side effects of opioid?

Miosis
Decrease peristalsis--->constipation
Urinary retention
Gallbladder spasm
Increase biliary pressure

9

Does opioid suppress or induce coughing/vomiting?

Suppress coughing (antitussive)
Induce vomiting

10

How is morphine metabolized and what is the effect of the metabolite?

Glucuronidation
Morphine-6-glucuronide--->high active

11

Opioid is contraindicated in pul dysfunction but what pul condition can opioid be benefit?

Pul edema

12

Which opioid cause mydrasis/tachycardia?

Meperidine--->anti M as well
Metabolized into normeperidine and act as a SSRI

13

Which opioid is used as a cough suppressant? CYP450 inhibitor increase or decrease the effect of codeine?

Codeine
Decrease--->codeine is a prodrug and is needed to be metabolized into morphine

14

What are the full and mixed agonist of mu receptor?

Full agonist-->meperidine/methadone/codeine
Mixed agonist--->buprenophine/nalbuphine/pentazocine

15

What receptors do these mixed agonist work on?

Mixed agonist--->stimulate kappa receptor/block mu receptor

16

What would happen if you take buprenophine/nalbuphine/pentazocine and a full mu agonist like heroine at the same time?

Cause heroine withdraw:
Heroine is a full mu agonist--->buprenophine/nalbuphine/pentazocine block mu--->cause heroine withdraw

17

Nalbuphine and pentazocine should not be given with?

A full mu agonist--->cause withdraw

18

What drug is used for opioid induced constipation?

Methylnaltrexone

19

Why is suboxone used for opiate addict?

Suboxone--->combo of buprenorphine + naloxone--->if taken IV---->get withdraw instead of a high

20

What are the withdraw signs of opioid?

Yawning/sweating/anxiety

21

What drugs are used to manage opioid withdrawal?

Methadone and clonidine (alpha 2 agonist to offside some of the sympathetic symptoms of opioid withdraw)

22

What is another drug besides codeine that can be used as antitussive?

Dextromethorphan

23

What are the mechanisms of cocaine and amphetamine? what are their withdraw symptoms?

Cocaine--->block reuptake of DA/NE/5HT
Amphetamine--->increase release and block reuptake NE
Withdraw--->depression like

24

What are the withdraw symptoms of benzo/barb/alcohol?

Stimulant like--->anxiety and agitation

25

What is the mechanism of weed?

Bind to CB1 and CB2 cannabinoid receptors

26

PCP works similarly like ___?

Ketamine-->they are both NMDA receptor blocker