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Unit 4 > Steroids > Flashcards

Flashcards in Steroids Deck (24)
1

Which steroids has the same level of effect as glucocorticoid and mineralocorticoid? and what are their duration of action?

Cortisol and hydrocortisol
short

2

Which steroids is a potent glucocorticoid w/o aldosterone effect? and what is its duration of action?

Dexamethasone
Long acting

3

What is glucocorticoid's effect on leukocyte?

Inhibit leukocyte migration

4

What does chronic use of glucocorticoid cause?

Cushing's syndrome/osteoporosis

5

What is chronic glucocorticoid's effect in stomach?

Inhibit PGs--->increase acid and pepsin release

6

Which 2 steroids have side effect such as HTN and edema?

Mineralocorticoid--->cortisol/hydrocortisol

7

Sudden stop of steroid tx can cause?

Adrenal insufficiency (Addison's disease)

8

How to minimize steroid toxicity?

Alternative day therapy/local application/tapering down

9

What are responsible for early asthmatic response?

Histamine and leukotriene

10

What drug can be used to test for asthma?

Look for hyper reactivity with methacholine (M agonist)

11

What do you see with late asthmatic response?

eosinophil and lymphocytes in the airway

12

How to approach asthma tx?

Bronchodilator and anti inflammatory

13

Adenosine cause bronchoconstriction or dilation?

Bronchoconctriction

14

What are the SABA and what are they used for?

Shorting acting beta 2 agonist--->DOC for acute asthma attack
Also prophylaxis for exercise induced asthma
Albuterol/metaproterenol/terbutaline

15

What are the LABA and what are they used for?

Long acting beta 2 agonist--->salmeterol/formoterol
Prophylaxis for nocturnal asthma

16

How is SABA and LABA administered and what happens with overuse?

Aerosol form
Anxiety/muscle tremor (beta2 effect on muscle)/cardiotoxicity

17

Ipratropium and tiotropium is most commonly used for asthma or COPD?

COPD

18

What is the mechanism of theophylline?

Inhibit phosphodiesterase type 3--->prevent degradation of cAMP--->bronchodilate
Block adenosine--->bronchodilate

19

Why is theophylline dangerous to use? and what is its toxicity?

Low TI--->interact with P450 inhibitors
High dose causes increase HR and arrhythmia

20

What drugs prevent mast cell degranulation thus have anti inflammatory effect? How are they used?

Cromoglycate and nedocromil
Alternative to glucocorticoid for asthma prophylaxis

21

What is MOA of omalizumab and what is it used for?

Anti-IgE--->prevent mast cell degranulation
Used subcutaneously for severe allergy induced asthma

22

What are the anti inflammatory drugs for asthma? how are they administered and what should you worry about?

budesonide/flunisolide/fluticasone
Inhalation--->risk for oral thrush

23

Which steroid is used intranasaly for allergy?

Fluticasone

24

How are "lukast" drugs given? and how are they used?

Orally
Prophylaxis