RA/gout tx Flashcards Preview

Unit 4 > RA/gout tx > Flashcards

Flashcards in RA/gout tx Deck (18)
1

What is the management of RA?

High dose NSAIDs (anti inflammatory)--->decrease pain and swelling
DMARDs--->slow disease progression (take a while to start working)

2

What is the side effect for methotrexate when treating RA and cancer?

Treating RA--->liver damage
Cancer (high dose)--->myleosuppression

3

What are the DMARDs?

Hydroxychloroquine
sulfasalazine/methotrexate/steroids
leflunomide/etanercept
infliximab/adalimumab
Anakinra

4

Which 2 DMARDs would cause hemolytic anemia with G6PD deficiency?

Hydroxychloroquine and sulfasalazine

5

Which DMARDs can cause cinchonism?

Hydroxychloroquine

6

Which 3 DMARDs target TNF? and what infection should you be concerned about these drugs

Etanercept/infliximab/adalimumab--->TB

7

What drug can you use for pt with Sjogrens syndrome?

Pilocarpine (M agonist)

8

What drugs are used to treat acute gout?

NSAIDs or colchicine

9

How does colchicine work and what other drugs have similar MOA? and where are they all bind to?

Inhibit microtubular polymerization
Drugs that work similarly:
Vincristine/vinblastine/paclitaxel (prevent disassembling)/griseofulvin (antifungal)
They all bind to tubulin

10

What is the side effect of colchicine?

Myelosuppression

11

What drugs are used for chronic gout? and what are their MOA?

Allopurinol and febuxostat--->inhibit xanthine oxidase--->decrease uric acid production

12

Allopurinol and febuxostat cause the elevated level of?

Hypoxanthine

13

What is the disease that is associated with HGPRT deficiency?

Lesch-Nyhan syndrome-->retardation and self mutilation

14

What does rasburicase?

Urate oxidase--->prevent tumor lysis syndrome--->reduces serum uric acid

15

When do we use allopurinol or rasburicase for tumor lysis syndrome?

Allopurinol--->use when uric acid level is normal before chemo
Rasburicase--->use when uric acid level is high before chemo

16

What is the drug that works similar to rasburicase?

Pegloticase

17

Which chronic gout drug that works in the kidney? and when shouldn't we use it?

Probenecid--->inhibit proximal tubular reabsorption of urate
It is ineffective if GFR is very low

18

What are the drug interactions with probenecid?

It inhibit secretion of weak acid drugs--->thus increase those drugs in the serum
e.g. antibiotics