Flashcards in RA/gout tx Deck (18)
What is the management of RA?
High dose NSAIDs (anti inflammatory)--->decrease pain and swelling
DMARDs--->slow disease progression (take a while to start working)
What is the side effect for methotrexate when treating RA and cancer?
Treating RA--->liver damage
Cancer (high dose)--->myleosuppression
What are the DMARDs?
Which 2 DMARDs would cause hemolytic anemia with G6PD deficiency?
Hydroxychloroquine and sulfasalazine
Which DMARDs can cause cinchonism?
Which 3 DMARDs target TNF? and what infection should you be concerned about these drugs
What drug can you use for pt with Sjogrens syndrome?
Pilocarpine (M agonist)
What drugs are used to treat acute gout?
NSAIDs or colchicine
How does colchicine work and what other drugs have similar MOA? and where are they all bind to?
Inhibit microtubular polymerization
Drugs that work similarly:
Vincristine/vinblastine/paclitaxel (prevent disassembling)/griseofulvin (antifungal)
They all bind to tubulin
What is the side effect of colchicine?
What drugs are used for chronic gout? and what are their MOA?
Allopurinol and febuxostat--->inhibit xanthine oxidase--->decrease uric acid production
Allopurinol and febuxostat cause the elevated level of?
What is the disease that is associated with HGPRT deficiency?
Lesch-Nyhan syndrome-->retardation and self mutilation
What does rasburicase?
Urate oxidase--->prevent tumor lysis syndrome--->reduces serum uric acid
When do we use allopurinol or rasburicase for tumor lysis syndrome?
Allopurinol--->use when uric acid level is normal before chemo
Rasburicase--->use when uric acid level is high before chemo
What is the drug that works similar to rasburicase?
Which chronic gout drug that works in the kidney? and when shouldn't we use it?
Probenecid--->inhibit proximal tubular reabsorption of urate
It is ineffective if GFR is very low