Pharm p. 242-244 Flashcards Preview

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Flashcards in Pharm p. 242-244 Deck (42)
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31

If a drug is mostly found in the ECF, what are the properties of the drug?

Made out of small hydrophilic molecules

32

after 4 half-lives, what % of the drug is remaining in body?

6.25%

33

A constant amount of drug eliminated per unit time is called?

Zero-order elimination

34

To treat overdose of a weak acidic drug one must administer what kind of drug?

basic drug

35

To treat overdose amphetamines, give which drug?

ammonium chloride

36

Examples of 3 drugs with Zero-order elimination at
high or toxic concentrations?

Phenytoin, Ethanol, and Aspirin "PEA"

37

A constant fraction of drug eliminated per unit time is called?

First-order elimination

38

Another name for Zero-order elimination?

Capacity-limited elimination.

39

Give 4 examples of acidic drug OD that Bicarbonate can treat?

phenobarbital
methotrexate
aspirin
TCAs

40

Another name for First-order elimination?

Flow-dependent elimination

41

In Phase II of metabolism, what is Conjugation referred to? "GAS"

Glucuronidation,
Acetylation,
Sulfation

42

Which of the met. phases yields metabolites that are renally excreted? and why?

Phase II
Because the metabolites are very polar and inactive