Pharm1E1 Cholinergic Antagonists & NM Drugs Flashcards Preview

Pharmacology > Pharm1E1 Cholinergic Antagonists & NM Drugs > Flashcards

Flashcards in Pharm1E1 Cholinergic Antagonists & NM Drugs Deck (57)
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1

atropine has high affinity for ? receptors and little to no affinity for ?

muscarinic- NONSELECTIVE for M1-M5
nicotine>> little to no effect at ganglia

2

tissues most sensitive to atropine? 3

salivary
bronchial
sweat

3

? is 5 times more selective for M1 over ? receptors

pirenzepine
M2

4

common s/e of musc. ant

dry mouth

5

sites with little cholinergic control i.e. ? wont respond significantly

blood vessels

6

antimuscarinics that enter the CNS can cause ? and ?

drowsiness
amnesia

7

treats motion sickness; s/e include dry mouth & ?

scopolamine
sedation

8

high doses of atropine results in?

tachycardia

9

low doses of atropine.. initially causes ? b/c
the ? receptors aka ? on the ? terminals are blocked; these receptors normally reduce synaptic release of ? so when they are blocked more Ach is released, resulting in bradycardia

bradycardia
presynaptic muscarinic
autoreceptors
vagal nerve
Ach

10

blockade of atrial muscle M2 receptors = no clinical significance except in ? or ?

atrial flutter, fibrillation

11

overall antimuscarinic effects on heart not dramatic: ? and little to no change in ?

tachycardia, blood pressure

12

atropine - respiratory - bronchodilation and reduction in?

bronchial secretions

13

in RS primary use is ? and ?

reduce secretions and prevent laryngospasm (inhalation anesthesia)

14

elevation of body temperature in infants aka?

atropine fever

15

antimuscarinics reduce ? but have little effect on ?

tremor, bradykinesia

16

drugs for PD? 3

cogentin
artane
norflex
aka CAN

17

topical app- eye
aids in measurement of ? and facilitates ?

refractive error
eye exam of retina

18

antimuscarinics for the eye? PACS TH

paremyd- combo of antimusc & sym-mimetic
atropine
cyclopentoate
scopolamine
tropicamide
homatropine

19

? is the longest acting on the eye

atropine

20

? is best for eye exams; shortest acting

tropicamide

21

respiratory- inhibit airway secretions & cause bronchodilation (5)

atropine
hyoscyamine
ipratropium
combivent
tiotropium

22

best for asthma?

combivent- activates B2!

23

1st line for COPD

ipratropium

24

GI- peptic ulcer 3
rarely used- PPIs more common

atropine
anaSPAZ
rubinol

25

Diarrhea drug- additive to ? to discourage abuse

lomotil, opioid

26

antispasmodics - 2
treats IBS & spastic colon

atropine
bentyl

27

only one for heart?
low dose =?
high dose=?

atropine
bradycardia (presynaptic inhibition)
tachycardia (may extend an infarct)

28

atropine can reverse ? in the heart and ? attacks aka ? can be blocked

bradycardia
vaso-vagal, syncope

29

GU- relieve urinary urgency/incontinence
s/e include ? and ?
name 6

ditropan XL
detrol LA
sanctura
toviaz
enablex
vesicare
**last two are M3 selective-detrusor muscle- overactive bladder

30

atropine very safe but CI in ? and ?

GLC, especially narrow angle closure
BPH- can precipitate urinary retention