Pharm1E1 Cholinergic Antagonists & NM Drugs Flashcards Preview

Pharmacology > Pharm1E1 Cholinergic Antagonists & NM Drugs > Flashcards

Flashcards in Pharm1E1 Cholinergic Antagonists & NM Drugs Deck (57)
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31

ganglionic blockade- all ganglia blocked bc all are ?, so the ? in ANS is prevented; drug?

nicotinic
reflex activity
inversine- DOES access the CNS

32

effect of inversine is opposite to the ?
all tone is PNS except for ?

dominant ANS tone
arterioles (S), veins (S), sweat glands (S), and G/U (both)

33

bv are dominant via SNS vasoconstrictor actions so mecamylamine (inversine) results in ? bc ?

postural/orthostatic hypotension
the postural reflexes that prevent venous pooling are blocked

34

on heart vagal tone dominates so ganglionic blockade >> ?

moderate tachycardia

35

mecamylamine (inversine) indicated for moderate to severe ? and is an orphan drug by FDA for ?

Htn
Tourette's
*also used for ADHD, drug withdrawal, reducing bleeding during surgery

36

inversine rarely used by can lower BP in emergency cases of ?

acute dissecting aortic aneurysm

37

NM blocking drugs are used as adjuncts to ?

general anesthesia

38

nicotinic receptor antagonists are ? agents

nondepolarizing

39

depolarizing agents activate ? i.e. ?

nicotinic receptors, succinylcholine

40

non depolarizing are given either ? or ? but are inactive if given?

IM, IV, orally

41

longer actings non depolarizing blockade drugs?
**difficult to reverse blockade!

tubocurarine (80-120hrs)
PANcuronium (120-180hrs)- pan = all so it needs a long time!

42

shorter acting non depolarizing blockade drugs?

atracurium (30-60 min), mivacurium (12-18 min)

43

rapid onset, low potency, intermediate duration?

rocuronium

44

nondepolarizing blocking drugs produce flaccid paralysis of muscle by inhibiting the ?

binding of ACh to nAChRs on muscle fibers

45

? can slightly block ganglionic neuronal nicotinic Ach receptors

tubocurarine

46

used in patients w/ multi system organ failure b/c their metabolism is independent of renal and hepatic function

atricurium, cisatracurium

47

has the fastest onset and is a useful alternative to succinylcholine for tracheal intubation?

rocuronium

48

tubocurarine produces ? due to stimulation of ? release and at high concentrations ganglionic blockade

hypotension
histamine

49

has a moderate increase in HR and CO due to blockade of cardiac muscarinic receptors?

pancuronium

50

? and ? can be used to ANTAGONIZE NM blockade

neoSTIGmine
pyridoSTIGmine

51

drugs:
? and ? can increase NM blockade

Ca channel blockers, anesthetics i.e. isoflurane

52

two molecules of Ach bind to the receptors a ? in the receptor results in the opening of an ion channel which allows the passage of ? into the cell causing membrane depolarization

conformational change
sodium ions

53

in succinylcholine initially the muscles display disorganized ? which is followed by ?

contractions
flaccid paralysis

54

despite repolarization the membrane cannot be ? as long as succinylcholine is present- resembles ? of the nAChRs

depolarized
sensitization

55

With succinylcholine, ? results if a second dose is given ? minutes after the first

bradycardia
five

56

during prolonged muscle depolarization, excessive ? is lost and significant Na, Cl, and Ca are gained by the muscle. excessive damage to the soft tissue the K released can cause significant ? occasionally causing cardiac arrest

potassium
hyperkalemia

57

halothane followed by administration of ? results in ?

malignant hyperthermia