Physio- Pituitary Gland Flashcards

(82 cards)

1
Q

Which part of the pituitary gland is considered the “master of endocrine glands”?
a) Neurohypophysis

b) Adenohypophysis

c) Pars intermedia

d) Infundibulum

A

B

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2
Q

The pituitary gland is located in the:

a) Sphenoid sinus

b) Cavernous sinus

c) Hypophyseal fossa of the sphenoid bone

d) Foramen magnum

A

C

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3
Q

Which of the following hormones is NOT secreted by the adenohypophysis?

a) Growth Hormone (GH)

b) Thyroid-Stimulating Hormone (TSH)

c) Oxytocin

d) Adrenocorticotropic Hormone (ACTH)

A

C

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4
Q

What type of cells in the adenohypophysis secrete growth hormone and prolactin?

a) Chromophobes

b) Acidophils

c) Basophils

d) Pituicytes

A

B

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5
Q

The neurohypophysis stores and releases which hormones?

a) TSH and ACTH

b) GH and Prolactin

c) Vasopressin (ADH) and Oxytocin

d) FSH and LH

A

C

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6
Q

What is Rathke’s pouch?

a) A part of the neurohypophysis

b) An ectodermal out-pocketing that forms the adenohypophysis

c) A structure in the hypothalamus

d) A blood vessel supplying the pituitary

A

B

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7
Q

Give the development of the pituitary gland.

A

Rathke’s pouch and Infundibum

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8
Q

A pituitary adenoma that secretes excessive growth hormone (GH) in an adult leads to:

a) Dwarfism

b) Gigantism

c) Acromegaly

d) Diabetes insipidus

A

C

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9
Q

Diabetes insipidus is a result of inadequate release of:

a) Growth hormone

b) Thyroid stimulating hormone

c) Antidiuretic hormone (ADH)

d) Prolactin

A

C

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10
Q

A hormone is best described as a:
A) Neurotransmitter that travels through the bloodstream.
B) Chemical messenger secreted by exocrine glands for distant targets.
C) Chemical messenger secreted by endocrine glands into the blood and transported to target cells.
D) Paracrine signaling molecule that acts on adjacent cells.

A

C) Chemical messenger secreted by endocrine glands into the blood and transported to target cells.

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11
Q

Which of the following physiological effects can be mediated by hormones?
A) Rapid propagation of action potentials along nerve fibers.
B) Cell growth, protein synthesis, and muscle contraction.
C) Localized inflammatory responses to tissue injury.
D) Exocrine secretion of digestive enzymes into the gut lumen.

A

B) Cell growth, protein synthesis, and muscle contraction.

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12
Q

Water-soluble hormones, such as peptide hormones and catecholamines:
A) Can readily diffuse across the lipid bilayer of the cell membrane.
B) Typically bind to intracellular receptors in the cytoplasm or nucleus.
C) Initiate their effects by binding to receptors on the cell surface, often leading to the generation of second messengers.
D) Primarily exert their effects by altering gene transcription directly.

A

C) Initiate their effects by binding to receptors on the cell surface, often leading to the generation of second messengers.

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13
Q

Lipid-soluble hormones, such as steroid and thyroid hormones:
A) Exert their primary effects by activating cell surface receptors.
B) Are unable to cross the cell membrane and require transport proteins for cellular entry.
C) Can diffuse through the cell membrane and bind to receptors located in the cytosol or nucleus.
D) Primarily trigger rapid, short-lived cellular responses.

A

C) Can diffuse through the cell membrane and bind to receptors located in the cytosol or nucleus.

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14
Q

The secretion of hormones is governed by various types of stimuli. Which of the following is an example of hormonal stimulation?

A) Increased plasma glucose levels leading to insulin release from the pancreas.

B) Sympathetic nervous system stimulation causing the release of catecholamines from the adrenal medulla.

C) The hypothalamus releasing thyrotropin-releasing hormone (TRH), which stimulates the anterior pituitary to release thyroid-stimulating hormone (TSH)

D) Low plasma calcium levels stimulating the secretion of parathyroid hormone.

A

C) The hypothalamus releasing thyrotropin-releasing hormone (TRH), which stimulates the anterior pituitary to release thyroid-stimulating hormone (TSH)

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15
Q

The hypophyseal portal system plays a critical role in:
A) Transporting hormones from the posterior pituitary to the systemic circulation.
B) Providing a direct neural connection between the hypothalamus and the anterior pituitary.
C) Delivering hypothalamic releasing and inhibiting hormones directly to the anterior pituitary.
D) Regulating blood flow to the posterior pituitary gland.

A

Delivering hypothalamic releasing and inhibiting hormones directly to the anterior pituitary.

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16
Q

Which of the following hormones is NOT a tropic hormone released from the anterior pituitary?
A) Thyroid-stimulating hormone (TSH).
B) Adrenocorticotropic hormone (ACTH).
C) Growth hormone (GH).
D) Follicle-stimulating hormone (FSH).

A

C) Growth hormone (GH)

Name your tropic hormones.

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17
Q

The hypothalamus controls the secretion of anterior pituitary hormones by producing:
A) Six effector hormones that directly act on peripheral tissues.
B) Releasing hormones that stimulate and inhibiting hormones that suppress anterior pituitary hormone secretion.
C) Tropic hormones that directly regulate peripheral endocrine glands.
D) Neurotransmitters that are released into the systemic circulation.

A

Releasing hormones that stimulate and inhibiting hormones that suppress anterior pituitary hormone secretion.

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18
Q

Negative feedback in the endocrine system is a mechanism that:
A) Amplifies the initial stimulus, leading to a greater hormonal response.
B) Maintains hormone levels within a narrow physiological range by inhibiting further hormone secretion.
C) Primarily regulates the secretion of water-soluble hormones.
D) Is less common than positive feedback in hormonal regulation.

A

B) Maintains hormone levels within a narrow physiological range by inhibiting further hormone secretion.

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19
Q

An example of hormonal secretion regulated by ion levels via negative feedback is:
A) Insulin secretion in response to high blood glucose.
B) Parathyroid hormone secretion in response to low plasma calcium.
C) Aldosterone secretion stimulated by the renin-angiotensin system.
D) Catecholamine release from the adrenal medulla in response to sympathetic stimulation.

A

B) Parathyroid hormone secretion in response to low plasma calcium.

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20
Q

Nutrient levels in the blood can directly influence hormone secretion. For instance, high plasma glucose levels stimulate the release of:
A) Glucagon from alpha cells of the pancreas.
B) Insulin from beta cells of the pancreas.
C) Somatostatin from delta cells of the pancreas.
D) Epinephrine from the adrenal medulla.

A

B) Insulin from beta cells of the pancreas.

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21
Q

Neurotransmitters can regulate hormone secretion in glands that:
A) Are located within the central nervous system.
B) Primarily secrete lipid-soluble hormones.
C) Receive autonomic innervation.
D) Are part of the hypothalamic-pituitary axis.

A

C) Receive autonomic innervation.

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22
Q

The release of prolactin from the anterior pituitary is stimulated by:
A) High levels of circulating dopamine.
B) Stimulation of tactile receptors in the mother’s nipples during breastfeeding.
C) Increased levels of growth hormone-inhibiting hormone (somatostatin).
D) Elevated levels of thyroid hormones.

A

B) Stimulation of tactile receptors in the mother’s nipples during breastfeeding.

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23
Q

Positive feedback in hormonal regulation is characterized by:
A) The inhibition of hormone secretion in response to rising hormone levels.
B) A mechanism that helps maintain homeostasis by counteracting changes in the internal environment.
C) The stimulation of further hormone secretion in response to the initial release of the hormone.
D) A slower and more prolonged response compared to negative feedback.

A

C) The stimulation of further hormone secretion in response to the initial release of the hormone.

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24
Q

The secretion of oxytocin during childbirth, where uterine contractions lead to further oxytocin release, is an example of:
A) Negative feedback regulation.
B) Short-loop negative feedback.
C) Positive feedback regulation.
D) Feedforward regulation.

A

C) Positive feedback regulation.

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25
Compared to neural regulation, hormonal regulation is generally: A) Faster and more localized. B) Slower and more broadly distributed throughout the body. C) More precise in its targeting of individual cells. D) Briefer in its duration of effects.
B) Slower and more broadly distributed throughout the body.
26
The duration of effect of a hormonally regulated response is typically longer than that of a neurally regulated response because: A) Hormones are released at a higher concentration than neurotransmitters. B) Endocrine glands have a more direct connection to their target cells. C) Hormones take longer to be metabolized and eliminated from the circulation. D) Hormonal signals always involve changes in gene transcription.
C) Hormones take longer to be metabolized and eliminated from the circulation.
27
When a rapid, precise, and highly localized response is needed, the body primarily relies on: A) Hormonal regulation. B) Neural regulation. C) Autocrine signaling. D) Paracrine signaling.
B) Neural regulation.
28
Tropic hormones released by the anterior pituitary gland primarily: A) Exert direct effects on peripheral tissues such as muscle and bone. B) Regulate the secretion of hormones by other endocrine glands. C) Act locally within the anterior pituitary to regulate their own secretion. D) Are synthesized and stored in the posterior pituitary before release.
B) Regulate the secretion of hormones by other endocrine glands.
29
An example of a releasing hormone produced by the hypothalamus that stimulates the anterior pituitary is: A) Dopamine, which inhibits prolactin secretion. B) Somatostatin, which suppresses growth hormone secretion. C) Thyrotropin-releasing hormone (TRH), which stimulates thyroid-stimulating hormone (TSH) secretion. D) Growth hormone-inhibiting hormone, which stimulates growth hormone secretion
C) Thyrotropin-releasing hormone (TRH), which stimulates thyroid-stimulating hormone (TSH) secretion.
30
The long negative feedback loop in the hypothalamic-pituitary-peripheral endocrine gland axis involves: A) Inhibition of the hypothalamus by a tropic hormone from the anterior pituitary. B) Inhibition of the anterior pituitary by a releasing hormone from the hypothalamus. C) Inhibition of both the hypothalamus and the anterior pituitary by a hormone secreted by the peripheral endocrine gland. D) Stimulation of the hypothalamus and anterior pituitary by a hormone from the peripheral endocrine gland.
C) Inhibition of both the hypothalamus and the anterior pituitary by a hormone secreted by the peripheral endocrine gland.
31
The release of catecholamines (adrenaline and noradrenaline) from the adrenal medulla is primarily stimulated by: A) Increased plasma glucose levels. B) Hormonal stimulation from the anterior pituitary. C) Sympathetic nervous system stimulation. D) Low plasma calcium levels.
C) Sympathetic nervous system stimulation.
32
The secretion of prolactin from the anterior pituitary is typically inhibited by: A) Thyrotropin-releasing hormone (TRH). B) Prolactin-releasing hormone. C) Dopamine D) Stimulation of the mother's nipples.
C) Dopamine
33
In contrast to neural regulation, hormonal regulation: A) Results in a rapid response that is short-lived. B) Involves direct structural connections between the signaling cell and the target cell. C) Typically produces a more generalized effect on target cells throughout the body. D) Relies on neurotransmitters released at synapses to transmit signals.
C) Typically produces a more generalized effect on target cells throughout the body.
34
35
State two ways in which ADH increases blood pressure and volume.
1. Through blood vessels via vasoconstriction of V1 receptors 2. Through the kidney via increases reabsorption of water via V2 receptors
36
Oxytocin produces effects for 2 target organs. Name the organs and its effects on the organ.
Uterus - stimulates uterine contractions of the cervix Breast - stimulates contractions of myoepithelial cells causing ejection of milk.
37
Contrast neural and hormonal regulation.
Neural regulation: Highly localized Structurally connected Short distance Fast regulation Brief effects _________ Hormonal regulation: Generalized and more broad Not connected Long distance Short regulation Long effects
38
Lactotrope cells in the anterior pituitary are primarily responsible for the production of: A) Growth hormone. B) Thyroid-stimulating hormone (TSH). C) Prolactin. D) Adrenocorticotropic hormone (ACTH).
C) Prolactin.
39
Stimulation of tactile receptors in the mother's nipples during suckling leads to an increase in the secretion of: A) Dopamine from the hypothalamus. B) Thyroid-releasing hormone (TRH) from the hypothalamus. C) Prolactin from the anterior pituitary. D) Oxytocin from the posterior pituitary.
C) Prolactin from the anterior pituitary.
40
Prolactin primarily exerts its physiological effects on which of the following tissues? A) Thyroid gland. B) Adrenal cortex. C) Mammary glands. D) Uterus.
C) Mammary glands.
41
The secretion of prolactin from the anterior pituitary is inhibited by which hormone produced in the hypothalamus? A) TRH. B) Gonadotropin-releasing hormone (GnRH). C) Dopamine. D) Corticotropin-releasing hormone (CRH).
C) Dopamine.
42
What type of receptor is the prolactin receptor located in the mammary gland? A) G-protein-coupled receptor. B) Enzyme-linked receptor. C) Intracellular nuclear receptor. D) Ligand-gated ion channel.
B) Enzyme-linked receptor. Enzyme: JAK
43
Activation of the prolactin receptor leads to the phosphorylation and activation of which intracellular transcription factor? A) cAMP response element-binding protein (CREB). B) Nuclear factor-kappa B (NF-κB). C) Signal transducers and activators of transcription (STAT). D) Activator protein 1 (AP-1).
C) Signal transducers and activators of transcription (STAT).
44
The proteins synthesized in mammary gland cells in response to prolactin signaling are primarily involved in: A) Collagen synthesis. B) Melanin production. C) Production of lactose, lipids, and casein. D) Glycogen synthesis.
C) Production of lactose, lipids, and casein.
45
During which physiological state are prolactin plasma levels typically at their lowest? A) Fetal life. B) Pregnancy. C) Postpartum during breastfeeding. D) Adult life, outside of pregnancy and lactation.
D) Adult life, outside of pregnancy and lactation. Also, menopause and parturition
46
Despite high plasma prolactin levels during pregnancy, lactation is inhibited due to: A) Down-regulation of prolactin receptors by high levels of estrogen and progesterone. B) Insufficient development of mammary gland alveoli. C) Increased levels of dopamine inhibiting prolactin action. D) Resistance of mammary gland cells to prolactin signaling.
A) Down-regulation of prolactin receptors by high levels of estrogen and progesterone.
47
Inability to lactate can be a consequence of: A) Excessive secretion of dopamine by the hypothalamus. B) A prolactin-secreting pituitary tumor. C) Destruction of the anterior pituitary lobe. D) Increased sensitivity of prolactin receptors.
C) Destruction of the anterior pituitary lobe.
48
Galactorrhea and infertility can result from an excess of prolactin, with infertility being caused by the inhibition of: A) Thyroid-stimulating hormone (TSH) secretion. B) Adrenocorticotropic hormone (ACTH) secretion. C) Growth hormone (GH) secretion. D) Gonadotropin-releasing hormone (GnRH) secretion.
D) Gonadotropin-releasing hormone (GnRH) secretion.
49
The growth-promoting effects of growth hormone are primarily mediated by the production of: A) Thyroid hormones in the thyroid gland. B) Cortisol in the adrenal cortex. C) Somatomedins (IGF-1 and IGF-2) in the liver. D) Insulin in the pancreas.
C) Somatomedins (IGF-1 and IGF-2) in the liver. IGFs: Promote protein synthesis Cell proliferation Growth of bone and cartilage Increase muscle mass Enlargement of visceral organs
50
Insulin-like growth factors (IGFs) stimulate: A) Lipolysis in adipose tissue. B) Glycogen breakdown in the liver. C) Protein synthesis and cell proliferation. D) Glucose uptake by the liver.
C) Protein synthesis and cell proliferation.
51
The growth-promoting effects of growth hormone are significantly enhanced by the presence of: A) Insulin. B) Glucagon. C) Thyroid hormones. D) Cortisol.
C) Thyroid hormones.
52
Growth hormone has direct metabolic effects on peripheral tissues, including: A) Increased fat deposition in adipose tissue. B) Increased utilization of glucose by skeletal muscle. C) Stimulation of lipolysis in adipose tissue. D) Increased glycogen synthesis in the liver.
C) Stimulation of lipolysis in adipose tissue. And also, decrease fat decomposition
53
Growth hormone contributes to increased plasma glucose levels by: A) Inhibiting gluconeogenesis in the liver. B) Increasing glucose uptake by adipose tissue. C) Decreasing the breakdown of glycogen in the liver. D) Stimulating gluconeogenesis and breakdown of glycogen in the liver.
D) Stimulating gluconeogenesis and breakdown of glycogen in the liver.
54
Overall, growth hormone exerts which type of effects on skeletal muscles and bones? A) Catabolic. B) Anabolic. C) Lipolytic. D) Glycogenolytic.
B) Anabolic. Effects: Decreases glucose uptake, increase hyperglycemia Catabolic for adipose tissue — increase lipolysis and decrease fat decomposition
55
The diabetogenic effects of growth hormone refer to its ability to: A) Enhance insulin sensitivity in peripheral tissues. B) Lower blood glucose levels by stimulating glucose uptake. C) Antagonize the effects of insulin, leading to increased plasma glucose. D) Promote glucose storage as glycogen.
C) Antagonize the effects of insulin, leading to increased plasma glucose.
56
Metabolic actions of growth hormone are aimed at increasing the production of: A) Glycogen and triglycerides. B) Amino acids and lactate. C) Free fatty acids and glucose. D) Ketone bodies and insulin.
C) Free fatty acids and glucose. Reason: For source of energy and to preserve amino acids for protein synthesis.
57
Growth hormone spares amino acids from metabolic use, making them available for: A) Energy production through the Krebs cycle. B) Fatty acid synthesis in adipose tissue. C) Synthesis of body proteins. D) Glycogen synthesis in muscles.
C) Synthesis of body proteins.
58
The growth hormone receptor is what type of receptor? A) Ion channel-linked receptor. B) G-protein-coupled receptor. C) Enzyme-linked receptor. D) Intracellular hormone receptor.
C) Enzyme-linked receptor. Enzyme: JAK
59
Stimulation of the growth hormone receptor leads to the activation of which enzyme? A) Adenylate cyclase. B) Phospholipase C. C) Janus kinase (JAK). D) Guanylate cyclase.
C) Janus kinase (JAK).
60
Activation of the JAK pathway by growth hormone receptor stimulation can lead to the phosphorylation and activation of: A) Only intracellular enzymes like phospholipase C. B) Only transcription factors like STAT. C) Both intracellular enzymes (e.g., phospholipase C) and transcription factors (e.g., STAT, IRS, SHC). D) Neither intracellular enzymes nor transcription factors.
C) Both intracellular enzymes (e.g., phospholipase C) and transcription factors (e.g., STAT, IRS, SHC).
61
The primary effect of growth hormone signaling through changes in gene expression is: A) Decreased synthesis of cellular proteins. B) Increased breakdown of cellular proteins. C) Increased synthesis of proteins, leading to tissue growth. D) Inhibition of cellular growth and proliferation.
C) Increased synthesis of proteins, leading to tissue growth.
62
Growth hormone secretion is typically highest during: A) Midday. B) The first few hours of nighttime sleep. C) Immediately after a meal rich in carbohydrates. D) During prolonged fasting in adulthood.
B) The first few hours of nighttime sleep.
63
Which of the following is a neurogenic factor that stimulates growth hormone secretion? A) Increased plasma glucose. B) Increased plasma fatty acids. C) Sleep. D) Starvation.
C) Sleep. Other neurogenic factors: Stress, Exercise and Trauma
64
Reduced plasma glucose levels typically lead to: A) Decreased secretion of growth hormone. B) Increased secretion of growth hormone. C) No change in growth hormone secretion. D) Inhibition of growth hormone receptor activity.
B) Increased secretion of growth hormone. Decrease glucose, decrease fatty acids, starvation and increase amino acids lead to increase secretion of growth hormone.
65
In childhood, increased production of growth hormone leads to: A) Dwarfism. B) Acromegaly. C) Giantism. D) Reduced visceral organ size.
C) Giantism.
66
In young age, deficiency of growth hormone results in: A) Increased bone density. B) Pituitary dwarfism with childlike body proportions. C) Enlargement of the hands and feet. D) Accelerated closure of epiphyseal plates leading to increased height.
B) Pituitary dwarfism with childlike body proportions.
67
In adulthood, excessive secretion of growth hormone causes: A) Pituitary dwarfism. B) Giantism. C) Acromegaly, characterized by thickening of cartilage and small bones. D) Generalized muscle hypertrophy.
C) Acromegaly, characterized by thickening of cartilage and small bones.
68
A common finding in patients with acromegaly due to excessive growth hormone secretion is: A) Decreased size of visceral organs. B) Hypotension and bradycardia. C) Cardiomegaly. D) Reduced bone mineral density.
C) Cardiomegaly.
69
In adult age, a deficiency of growth hormone can lead to: A) Increased muscle mass and reduced adiposity. B) Decreased bone mineral density and increased lean body mass. C) Generalized obesity, reduced muscle mass, and diminished bone mineral density. D) Enhanced insulin sensitivity and lower plasma glucose levels.
C) Generalized obesity, reduced muscle mass, and diminished bone mineral density.
70
Oxytocin and vasopressin are synthesized by magnocellular neurons located in the: A) Anterior pituitary gland. B) Posterior pituitary gland. C) Supraoptic and paraventricular nuclei of the hypothalamus. D) Pineal gland.
C) Supraoptic and paraventricular nuclei of the hypothalamus.
71
Oxytocin and vasopressin are transported to the posterior pituitary via the: A) Hypophyseal portal system. B) Systemic circulation. C) Hypothalamo-hypophyseal tract. D) Cerebrospinal fluid.
C) Hypothalamo-hypophyseal tract.
72
Oxytocin primarily targets which two organs? A) Liver and kidneys. B) Thyroid gland and adrenal gland. C) Uterus and breasts. D) Pancreas and ovaries/testes.
C) Uterus and breasts.
73
In the uterus and breast, oxytocin stimulates what?
Uterus- Contractions of the uterine muscle during delivery. Breast - Contractions of myoepithelial cells around alveoli, causing milk ejection.
74
Release of oxytocin from the posterior pituitary is increased by: A) Decreased blood osmolarity. B) Elevated levels of progesterone. C) Mechanical stimulation of the mother’s nipples by suckling infant. D) Low levels of circulating estrogen.
C) Mechanical stimulation of the mother’s nipples by suckling infant Also: Uterine contractions during labor.
75
The mechanism regulating oxytocin secretion during childbirth, where uterine contractions lead to further oxytocin release, is an example of: A) Negative feedback. B) Feedforward regulation. C) Positive feedback. D) Autocrine signaling.
C) Positive feedback.
76
Oxytocin is a peptide hormone that acts through which type of receptor? A) Enzyme-linked receptor. B) Ligand-gated ion channel. C) G-protein-coupled receptor. D) Intracellular nuclear receptor.
C) G-protein-coupled receptor. Also: ADH
77
Signaling through the oxytocin receptor involves which pathway? A) Adenylate cyclase-cAMP pathway. B) Janus kinase-STAT pathway. C) Phospholipase C pathway. D) Receptor tyrosine kinase pathway.
C) Phospholipase C pathway.
78
Vasopressin (ADH) primarily regulates: A) Blood glucose levels. B) Calcium homeostasis. C) Urine output, circulatory blood volume, and blood pressure. D) Metabolic rate.
C) Urine output, circulatory blood volume, and blood pressure.
79
In the kidney, vasopressin acts via which receptor to stimulate water reabsorption in the collecting ducts? A) V1-receptor. B) V2-receptor. C) Alpha-adrenergic receptor. D) Beta-adrenergic receptor.
B) V2-receptor.
80
The effect of vasopressin on arterial vessels is to induce: A) Vasodilation. B) Vasoconstriction. C) Increased capillary permeability. D) Decreased lymphatic drainage.
B) Vasoconstriction- V1 receptors
81
A patient with diabetes insipidus due to reduced vasopressin secretion would likely exhibit: A) Severe hypoglycemia. B) Excessive fluid retention and edema. C) Excretion of large volumes of highly diluted urine (polyuria). D) Decreased thirst and fluid intake.
C) Excretion of large volumes of highly diluted urine (polyuria).
82
An increase in blood osmolarity, such as during dehydration, is sensed by osmoreceptors in the hypothalamus, leading to increased release of: A) Aldosterone. B) Renin. C) Vasopressin. D) Atrial natriuretic peptide.
C) Vasopressin