Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Renal > Flashcards

Renal Flashcards

1
Q

Drug class for Sevelamer

A

nonhormonal regulators of mineral homeostasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

MoA for Sevelamer

A

non-absorbed phosphate binder prevents absorption promoting excretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Indications for Sevelamer

A

hyperphosphatemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

SE/ADRs for Sevelamer

A

N/V/D, constipation, rash

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Contra-indications for Sevelamer

A

hypophosphatemia, bowel obstruction, dysphagia, bowel disorders, may decrease Vit D, E, K, folate absorption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Dx-Dx interactions for Sevelamer

A

may decrease absorption of Ciprofloxin, anti-seizure drugs, anti-arrhythmic drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Monitoring for Sevelamer

A

Ca+, PO4, Ca-P product

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Drug class for Cinacalcet

A

nonhormonal regulator of mineral homeostasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

MoA for Cinacalcet

A

reduces PTH secretion by sensitizing PT gland Ca+ receptors (mimics action of Ca+ at receptor) lowering Ca+ & phosphorous levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Indications for Cinacalcet

A

elevated serum PTH, Ca+, Ca-P product

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

SE/ADRs for Cinacalcet

A

hypocalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Contra-indications for Cinacalcet

A

hypocalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Dx-Dx interactions for Cinacalcet

A

anti-seizure meds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Monitoring for Cinacalcet

A

serum Ca+, PO4, Ca-P product

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Drug class for HCTZ

A

nonhormonal regulator of mineral homeostasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

MoA for HCTZ

A

Na-Cl symporter inhibition in the DCT increasing Na & Cl excretion max 5% of filtered NaCl

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Indications for HCTZ

A

HTN, edema in nephrotic syndrome, lithium induced diabetes insipidous (off-label_

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

SE/ADRs for HCTZ

A

rare vertigo, anorexia, nausea, photosensitivity,QT prolongation, hypokalemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Contra-indications for HCTZ

A

hypersensitivity, sulfa sensitivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Dx-Dx interactions for HCTZ

A

BBs increase risk of hyperglycemia, may decrease renal excretion of Li, NSAIDs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Monitoring for HCTZ

A

serum K+, glucose, BP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Drug class for CaCO3

A

nonhormonal regulator of mineral homeostasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

MoA for CaCO3

A

bind to phosphorous in GI tract & excreted

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Indications for CaCO3

A

CKD w/ hyperphosphatemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

SE/ADRs for CaCO3

A

constipation, hypercalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Contra-indications for CaCO3

A

hypercalcemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Dx-Dx interactions for CaCO3

A

antagonizes Verapamil, Thiazides increases Ca+, decrease Atenolol absorption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Monitoring for CaCO3

A

serum Ca+, PO4, Ca-P product

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Drug class for Calcitrol

A

nonhormonal regulator of mineral homeostasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

MoA for Calcitrol

A

up-regulates Vit D receptor of PT gland decreasing gland hyperplasia & PTH synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Indications for Calcitrol

A

reduction of PTH levels; hypocalcemia in ESRD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

SE/ADRs for Calcitrol

A

anorexia, constipation, arrhythmias, HTN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Contra-indications for Calcitrol

A

hypercalcemia, Vit D toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Dx-Dx interactions for Calcitrol

A

may increase risk of digitalis toxicity, steroids may decrease Ca absorption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Monitoring for Calcitrol

A

BUN, eGFR, Ca+, PO4, Ca-P product, PTH levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Drug class for Erythropoetin

A

erythropoesis stimulants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

MoA for Erythropoetin

A

stimulates erythroblasts to proliferate & differentiate into normoblasts, then reticulocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Indications for Erythropoetin

A

anemia in CKD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

SE/ADRs for Erythropoetin

A

fever, dizziness, pruritis, increased BP, thromboembolic events, edema, DVT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

Contra-indications for Erythropoetin

A

caution w/ high BP (greater than 180/100), seizure hx, hypersensitivity to human albumin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

Dx-Dx interactions for Erythropoetin

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

Monitoring for Erythropoetin

A

transferrin saturation, serum ferritin, BP, Hgb, serum chemistries, CBC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

Drug class for MgCL

A

electrolyte supplement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

MoA for MgCL

A

supplement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

Indications for MgCL

A

hypomagnesemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

SE/ADRs for MgCL

A

diarrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

Contra-indications for MgCL

A

elevated serum Mg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

Dx-Dx interactions for MgCL

A

none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

Monitoring for MgCL

A

serum Mg, K+, Ca+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

Drug class for KCL

A

electrolyte supplement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

MoA for KCL

A

electrolyte supplement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

Indications for KCL

A

hypokalemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

SE/ADRs for KCL

A

rash, hyperkalemia, caustic to mucosa in esophagus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
54
Q

Contra-indications for KCL

A

severe renal impairment, esophageal disorders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
55
Q

Dx-Dx interactions for KCL

A

none

56
Q

Monitoring for KCL

A

serum K+, glucose

57
Q

Drug class for HCTZ, Chlorthalidone, Metolazone, Indapamide

A

diuretics: thiazides

58
Q

MoA for HCTZ, Chlorthalidone, Metolazone, Indapamide

A

Na-Cl symporter inhibition in the DCT increasing Na & Cl excretion, max 5% of filtered Na

59
Q

Indications for HCTZ, Chlorthalidone, Metolazone, Indapamide

A

HTN, edema in nephrotic syndrome, litium induced diabetes insipidus (off label)

60
Q

SE/ADRs for HCTZ, Chlorthalidone, Metolazone, Indapamide

A

rare vertigo, anorexia, nausea, photosensitivity, QT prolongations, hypokalemia

61
Q

Contra-indications for HCTZ, Chlorthalidone, Metolazone, Indapamide

A

hypersensitivity, sulfa sensitivity

62
Q

Dx-Dx interactions for HCTZ, Chlorthalidone, Metolazone, Indapamide

A

BBs increase risk of hyperglycemia, may decrease renal excretion of Li, NSAIDs

63
Q

Monitoring for HCTZ, Chlorthalidone, Metolazone, Indapamide

A

serum K+, glucose, BP

64
Q

Drug class for Furosemide

A

loop diuretic

65
Q

MoA for Furosemide

A

inhibits Na/K/Cl symporter in TAL of loop & distal tubule

66
Q

Indications for Furosemide

A

edema sec to CHF, renal failure, liver failure

67
Q

SE/ADRs for Furosemide

A

hypotension, dehydration, hyperglycemia, decrease then increase serum uric acid, electrolyte abnormalities, cholestatic jaundice

68
Q

Contra-indications for Furosemide

A

sulfa sensitivity

69
Q

Dx-Dx interactions for Furosemide

A

increase impact of anti-hypertensives, lithium; corticosteroids increase Furosemide impact

70
Q

Monitoring for Furosemide

A

serum electrolytes, BUN, CrCl

71
Q

What is the outpatient target body weight loss/day for Furosemide?

A

about 2lbs wt loss/day

72
Q

Drug class for Torsemide

A

loop diuretic

73
Q

MoA for Torsemide

A

inhibits Na/K/Cl symporter in TAL loop & distal tubule

74
Q

indications for Torsemide

A

edema of cardia, renal, hepatic failure; HTN

75
Q

SE/ADRs for Torsemide

A

constipation, diarrhea

76
Q

Contra-indications for Torsemide

A

sulfa sensitivity, anuria

77
Q

Dx-Dx interactions for Torsemide

A

other K+ wasting drugs

78
Q

Monitoring for Torsemide

A

serum K+, BP, daily wt, eGFR

79
Q

PG category for Torsemide

A

avoid

80
Q

Drug class for Ethacrynic Acid

A

loop diuretic

81
Q

MoA for Ethacrynic Acid

A

inhibits Na/K/Cl cymporter in TAL of loop & distal tubule

82
Q

Indications for Ethacrynic Acid

A

edema sec to CHF, renal failure, liver failure

83
Q

SE/ADRs for Ethacrynic Acid

A

hypotension, dehydration, hyperglycemia, decrease then increase serum uric acid, electrolyte abnormalities, jaundice

84
Q

Contra-indications for Ethacrynic Acid

A

hypersensitivity, hx severe watery diarrhea w/ Ethacrynic acid

85
Q

Dx-Dx interactions for Ethacrynic Acid

A

increase impact of anti-hypertensives, lithium; corticosteroids increase diuretic impact

86
Q

Monitoring for Ethacrynic Acid

A

serum electrolytes, BUN, CrCl, BP

87
Q

Drug class for Spironolactone

A

potassium sparing diuretic: aldosterone antagonist

88
Q

MoA for Spironolactone

A

competitive antagonist at aldosterone mineralcorticoid receptors in DCT increasing NaCl & water loss but retention K+

89
Q

Indications for Spironolactone

A

edema from excess aldosterone secretion, hypokalemia, HF

90
Q

SE/ADRs for Spironolactone

A

gynecomastia, hyperkalemia, agranulocytosis, liver toxicity

91
Q

Contra-indications for Spironolactone

A

hypersensitivity, anuria, hyperkalemia

92
Q

Dx-Dx interactions for Spironolactone

A

K+ supplements, K+ retaining drugs

93
Q

Monitoring for Spironolactone

A

serum electrolytes, BUN, CrCl

94
Q

Drug class for Eplenerone

A

potassium sparing diuretic: aldosterone antagonist

95
Q

MoA for Eplenerone

A

competitive antagonist at aldosterone mineralcorticoid receptors in DCT increasing NaCl & water loss w/ retention K+

96
Q

Indications for Eplenerone

A

edema from excess aldosterone secretion, hypokalemia, HF

97
Q

Contra-indications for Eplenerone

A

hyperkalemia

98
Q

Contra-indications for Eplenerone

A

hyperkalemia, CrCl less than 50mL/min

99
Q

Dx-Dx interactions for Eplenerone

A

other K+ sparing diuretics

100
Q

Monitoring for Eplenerone

A

electrolytes, BUN, CrCl, BP

101
Q

Drug lass for Amiloride

A

potassium sparing

102
Q

MoA for Amiloride

A

direct inhibitor of Na+ influx in DCT & CCT

103
Q

Indications for Amiloride

A

hypokalemia, edema sec to CHF, cirrhosis

104
Q

SE/ADRs for Amiloride

A

HA, N/V/D, dyspnea, hyperkalemia, impotence

105
Q

Contra-indications for Amiloride

A

hypersentivity, serum K+ greater than 6.5meq/L, renal failure

106
Q

Dx-Dx interactions for Amiloride

A

other K+ retaining meds

107
Q

Monitoring for Amiloride

A

serum electrolytes, BUN, CrCl

108
Q

Drug class for Triamterene

A

adjunct K+ sparing

109
Q

MoA for Triamterene

A

direct inhibitor of Na+ influx in DCT & CCT

110
Q

Indications for Triamterene

A

hypokalemia, edema sec to CHF, cirrhosis

111
Q

SE/ADRs for Triamterene

A

hypotension, edema, constipation, dyspnea, hyperkalemia

112
Q

Contra-indications for Triamterene

A

hypersensitivity, hyperkalemia, CrCl less than 10mL/min

113
Q

Dx-Dx interactions for Triamterene

A

other K+ retaining meds

114
Q

Monitoring for Triamaterene

A

serum electrolytes, BUN, CrCl

115
Q

Drug class for Mannitol

A

Osmotic

116
Q

MoA for Mannitol

A

Osmosis producing increased water loss

117
Q

Indications for Mannitol

A

Reduction of intracranial or intraocular pressure, rhabdomyolysis

118
Q

SE/ADRs for Mannitol

A

HA, N/V, extra cellular fluid expansion, dehydration, hyperkalmia, hypernatremia, pulmonary edema, CHF

119
Q

Contra-indications for Mannitol

A

Renal failure, lack of response to test dose

120
Q

Dx-Dx interactions for Mannitol

A

None

121
Q

Monitoring for Mannitol

A

Serum electrolytes, BUN, CrCl

122
Q

Drug class for Acetozolamide

A

carbonic anhydrase inhibitor

123
Q

MoA for Acetozolamide

A

reversibly blocks carbonic anhydrase in PCT maintaining NaHCO3 in tubule lumen resulting in diuresis

124
Q

Indications for Acetozolamide

A

glaucoma, altitude sickness

125
Q

SE/ADRs for Acetozolamide

A

flushing, ataxia, electrolyte imbalance, confusion, convulsions, SJS

126
Q

Contra-indications for Acetozolamide

A

sulfa sensitivity

127
Q

Dx-Dx interactions for Acetozolamide

A

may increase levels of anti-hypertensives, anticonvulsants, alcohol

128
Q

Monitoring for Acetozolamide

A

serum electrolytes, BP

129
Q

What drug interferes with secretion of loop diuretics?

A

NSAIDs

130
Q

Furosemide, Bumetadine, and Torsemide are all sulfa drugs and have the potential for large losses of what ions in the urine?

A

K+, Mg++

131
Q

How is Mannitol administered?

A

IV for systemic effect

132
Q

Mannitol is not metabolized, it is ____?

A

filtered via glomerulus

133
Q

Pathophysiology of NSAIDs

A

inhibit PGE production resulting in unopposed afferent renal arteriole AT2 impact -> vasoconstriction; interferes w/ PGE modulated inhibition of Na & Cl re-absorption

134
Q

Who is at risk with NSAIDs?

A

CHF, CKD, hypovolemia, hepatic cirrhosis

135
Q

What is the renal impact of Cyclosporine

A

causes renal vasoconstriction

Pharmacology (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions