Cardiovascular 2 Anti-arrhythmics Flashcards Preview

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Flashcards in Cardiovascular 2 Anti-arrhythmics Deck (57)
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1

Drug class for Procainamide

class 1A Na channel

2

MoA for Procainamide

Decreases myocardial excitability and conduction velocity and may depress myocardial contractility, by increasing the electrical stimulation threshold of ventricle, His-Purkinje system and through direct cardiac effects (UtD)

3

Indications for Procainamide

life threatening ventricular arrhythmias

4

SE/ADRs for Procainamide

hypotension, N/V/D, SLE sxs, agranulocytosis (w/ prolonged use), QTc prolongation

5

Contra-indications for Procainamide

complete heart block, 2nd deg AV block, SLE, tornadoes de pointes

6

Dx-Dx interactions for Procainamide

other anti-arrhythmics

7

Monitoring for Procainamide

ECG, BP, eGFR, BUN, CBC, ANA titers, liver function, procainamide/NAPA conc (in liver disease)

8

PG category for Procainamide

PG C

9

Drug class for Lidocaine

class 1B Na channel

10

MoA for Lidocaine

blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions, suppresses automaticity of conduction tissue, by increasing electrical stimulation threshold of ventricle, His-Purkinje system, and spontaneous depolarization of the ventricles during diastole (UtD)

11

Indications for Lidocaine

suppression of existing ventricular arrhythmias

12

SE/ADRs for Lidocaine

arrhythmias, CV collapse, increase defib threshold, edema, heart block, hypotension, agitation, anxiety, metallic, taste, bronchospasm

13

Contra-indications for Lidocaine

severe SA, AV interventricular heart block w/out pacemaker, corn allergy

14

Dx-Dx interaction for Lidocaine

multiple (prolonged use)

15

Monitoring for Lidocaine

liver function, serum concentration, ECG, BP

16

PG category for Lidocaine

PG B

17

Drug class for Flecainide

class 1C Na channel

18

MoA for Flecainide

slows conduction in cardiac tissue by altering transport of ions across cell membranes; causes slight prolongation of refractory periods; increases electrical stimulation threshold of ventricle, His-Purkinje system

19

Indications for Flecainide

ventricular arrhythmias (prevention); PSVT (prevention); paroxysmal A fib/flutter

20

SE/ADRs for Flecainide

dizziness, blurred vision, dyspnea, palpitations, HA, pro-arrhythmic potential

21

Contra-indications for Flecainide

pre-existing 2 or 3 deg heart block, RBBB w/out pacemaker, cardiogenic shock

22

Dx-Dx interactions for Flecainide

multiple

23

Monitoring for Flecainide

ECG, BP, HR, periodic trough serum levels w/ renal or liver impairment

24

PG category for Flecainide

PG C

25

Flecainide should not be used for what chronic arrhythmia?

A fibrillation

26

Drug class for Amiodarone

Class 3 Repolarization delay

27

MoA for Amiodarone

inhibits adrenergic stimulation (alpha/beta) affecting Na, K, Ca channels; prolongs action potential & refractory period in cardiac tissues; decrease AV conduction & sinus node function

28

Indications for Amiodarone

life-threatening recurrent VF, unresponsive or unstable VT refractory to other anti-arrhythmic; off label- AF, PSVT, adjunct to ICD to suppress ventricular tacky in otherwise optimally tx patients w/ HF

29

SE/ADRs for Amiodarone

pulm toxicity, exacerbation of arrhythmias, optic neuritis, photosensitivity

30

Contra-indications for Amiodarone

hypersensitivity to iodine, cardiogenic shock, severe sinus node dysfunction, 2nd or 3rd deg HB or severe bradycardia without pacemakers