Anti-neoplastics Flashcards Preview

Pharmacology > Anti-neoplastics > Flashcards

Flashcards in Anti-neoplastics Deck (35):
1

Drug class for Cyclophosphimide

Alkylating agents

2

MoA for Cyclophosphimide

DNA cross linker (inhibits DNA synthesis & cell division)

3

Indications for Cyclophosphimide

leukemia, lymphoma, nephrotic syndrome, multiple immune mediated diseases

4

Drug class for Carbumustine

Alkylating agents: nitroureas

5

MoA for Carbumustine

DNA cross linker (inhibits DNA synthesis & cell division)

6

Indications for Carbumustine

brain tumors, multiple myeloma, lymphoma

7

Drug class for Cisplatin

Platinum analogs

8

MoA for Cisplatin

DNA cross linker triggering apoptosis

9

Indications for Cisplatin

small cell lung cancer, ovarian cancer, lymphoma, germ cell tumors

10

Drug class for Methotrexate

Antimetabolites: antifolate

11

MoA for Methotrexate

inhibits dihydrofolate reductase & DNA production, inhibits production of cytokines

12

Indications for Methotrexate

recent RA (less than 6 months), low disease activity, no poor prognostic features, cancer remission

13

Drug class for 5flurouracil

Antimetabolites: fluropyrimidines

14

MoA for 5flurouracil

-suicide inhibitor through inhibition of thymidylate synthase

-F-UMP pump interferes w/ RNA/DNA synthesis by replacing nucelic acid bases

15

Indications for 5flurouracil

anal, breast, colorectal, stomach, pancrease, head & neck cancers

16

Drug class for Cytarabine

Antimetabolite: deoxycitidine analogs

17

MoA for Cytarabine

intereferes with DNA and RNA polymerase synthesis

18

Indications for Cytarabine

AML, non-Hodgkin lymphoma

19

Drug class for 6MTP

Antimetabolites: purine antagonists

20

MoA for 6MTP

-competes with hypoxanthine & guanine for the enzyme HGPRTase & is convereted to thioinosinic acid

-inhibits DNA synthesis

21

Indications for 6MTP

leukemia, Non-Hodgkins, psoriatic arthritis, polycythemia vera, Crohn's

22

Drug class for Vincristine

Vinka alkaloids

23

MoA for Vincristine

binds to tubulin dimers, inhibiting assembly of microtubule structures & arresting mitosis in metaphase (inhibiting DNA synthesis)

24

Indications for Vincristine

non-Hodgkins, ALL

25

Drug class for Paclitaxel

-Taxanes

 

26

MoA for Paclitaxel

-Inhibiting assembly of microtubule structures, arresting chromosome segregation & cell division

--inhibits DNA synthesis by inhibiting formation of the mitotic spindle in the "M" phase

27

Indications for Paclitaxel

-ovarian, breast, lung, bladder, prostate, melanoma, esophageal, Kaposi's sarcoma

*not leukemias & lymphomas

28

Drug class for Doxorubicine

Antitumor antibiotics

29

MoA for Doxorubicin

-interacts w/ DNA binding macromolecular biosynthesis

-inhibits topoisomerase II

-unclear bu inhibits DNA synthesis

30

Indications for Doxorubicin

leukemia, Hodgkin's, bladder, breast, stomach, lung, ovaries, thyroid, sarcoma, multiple myeloma

31

Drug class for Cetuximab

Misc GFR inhibitors

32

MoA for Cetuximab

monoclonal mouse-human IgE antibody

33

Indications for Cetuximab

colorectal metastatic (& head & neck)

34

Drug class for Pegaspargase

Misc GFR inhibitors

35

Indications for Pegaspargase

only used in ALL if patient has allergy to first line drug