Anti-neoplastics Flashcards

1
Q

Drug class for Cyclophosphimide

A

Alkylating agents

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2
Q

MoA for Cyclophosphimide

A

DNA cross linker (inhibits DNA synthesis & cell division)

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3
Q

Indications for Cyclophosphimide

A

leukemia, lymphoma, nephrotic syndrome, multiple immune mediated diseases

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4
Q

Drug class for Carbumustine

A

Alkylating agents: nitroureas

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5
Q

MoA for Carbumustine

A

DNA cross linker (inhibits DNA synthesis & cell division)

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6
Q

Indications for Carbumustine

A

brain tumors, multiple myeloma, lymphoma

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7
Q

Drug class for Cisplatin

A

Platinum analogs

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8
Q

MoA for Cisplatin

A

DNA cross linker triggering apoptosis

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9
Q

Indications for Cisplatin

A

small cell lung cancer, ovarian cancer, lymphoma, germ cell tumors

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10
Q

Drug class for Methotrexate

A

Antimetabolites: antifolate

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11
Q

MoA for Methotrexate

A

inhibits dihydrofolate reductase & DNA production, inhibits production of cytokines

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12
Q

Indications for Methotrexate

A

recent RA (less than 6 months), low disease activity, no poor prognostic features, cancer remission

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13
Q

Drug class for 5flurouracil

A

Antimetabolites: fluropyrimidines

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14
Q

MoA for 5flurouracil

A
  • suicide inhibitor through inhibition of thymidylate synthase
  • F-UMP pump interferes w/ RNA/DNA synthesis by replacing nucelic acid bases
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15
Q

Indications for 5flurouracil

A

anal, breast, colorectal, stomach, pancrease, head & neck cancers

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16
Q

Drug class for Cytarabine

A

Antimetabolite: deoxycitidine analogs

17
Q

MoA for Cytarabine

A

intereferes with DNA and RNA polymerase synthesis

18
Q

Indications for Cytarabine

A

AML, non-Hodgkin lymphoma

19
Q

Drug class for 6MTP

A

Antimetabolites: purine antagonists

20
Q

MoA for 6MTP

A
  • competes with hypoxanthine & guanine for the enzyme HGPRTase & is convereted to thioinosinic acid
  • inhibits DNA synthesis
21
Q

Indications for 6MTP

A

leukemia, Non-Hodgkins, psoriatic arthritis, polycythemia vera, Crohn’s

22
Q

Drug class for Vincristine

A

Vinka alkaloids

23
Q

MoA for Vincristine

A

binds to tubulin dimers, inhibiting assembly of microtubule structures & arresting mitosis in metaphase (inhibiting DNA synthesis)

24
Q

Indications for Vincristine

A

non-Hodgkins, ALL

25
Q

Drug class for Paclitaxel

A

-Taxanes

26
Q

MoA for Paclitaxel

A

-Inhibiting assembly of microtubule structures, arresting chromosome segregation & cell division

–inhibits DNA synthesis by inhibiting formation of the mitotic spindle in the “M” phase

27
Q

Indications for Paclitaxel

A

-ovarian, breast, lung, bladder, prostate, melanoma, esophageal, Kaposi’s sarcoma

*not leukemias & lymphomas

28
Q

Drug class for Doxorubicine

A

Antitumor antibiotics

29
Q

MoA for Doxorubicin

A
  • interacts w/ DNA binding macromolecular biosynthesis
  • inhibits topoisomerase II
  • unclear bu inhibits DNA synthesis
30
Q

Indications for Doxorubicin

A

leukemia, Hodgkin’s, bladder, breast, stomach, lung, ovaries, thyroid, sarcoma, multiple myeloma

31
Q

Drug class for Cetuximab

A

Misc GFR inhibitors

32
Q

MoA for Cetuximab

A

monoclonal mouse-human IgE antibody

33
Q

Indications for Cetuximab

A

colorectal metastatic (& head & neck)

34
Q

Drug class for Pegaspargase

A

Misc GFR inhibitors

35
Q

Indications for Pegaspargase

A

only used in ALL if patient has allergy to first line drug