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Flashcards in Anti-neoplastics Deck (35)
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1

Drug class for Cyclophosphimide

Alkylating agents

2

MoA for Cyclophosphimide

DNA cross linker (inhibits DNA synthesis & cell division)

3

Indications for Cyclophosphimide

leukemia, lymphoma, nephrotic syndrome, multiple immune mediated diseases

4

Drug class for Carbumustine

Alkylating agents: nitroureas

5

MoA for Carbumustine

DNA cross linker (inhibits DNA synthesis & cell division)

6

Indications for Carbumustine

brain tumors, multiple myeloma, lymphoma

7

Drug class for Cisplatin

Platinum analogs

8

MoA for Cisplatin

DNA cross linker triggering apoptosis

9

Indications for Cisplatin

small cell lung cancer, ovarian cancer, lymphoma, germ cell tumors

10

Drug class for Methotrexate

Antimetabolites: antifolate

11

MoA for Methotrexate

inhibits dihydrofolate reductase & DNA production, inhibits production of cytokines

12

Indications for Methotrexate

recent RA (less than 6 months), low disease activity, no poor prognostic features, cancer remission

13

Drug class for 5flurouracil

Antimetabolites: fluropyrimidines

14

MoA for 5flurouracil

-suicide inhibitor through inhibition of thymidylate synthase

-F-UMP pump interferes w/ RNA/DNA synthesis by replacing nucelic acid bases

15

Indications for 5flurouracil

anal, breast, colorectal, stomach, pancrease, head & neck cancers

16

Drug class for Cytarabine

Antimetabolite: deoxycitidine analogs

17

MoA for Cytarabine

intereferes with DNA and RNA polymerase synthesis

18

Indications for Cytarabine

AML, non-Hodgkin lymphoma

19

Drug class for 6MTP

Antimetabolites: purine antagonists

20

MoA for 6MTP

-competes with hypoxanthine & guanine for the enzyme HGPRTase & is convereted to thioinosinic acid

-inhibits DNA synthesis

21

Indications for 6MTP

leukemia, Non-Hodgkins, psoriatic arthritis, polycythemia vera, Crohn's

22

Drug class for Vincristine

Vinka alkaloids

23

MoA for Vincristine

binds to tubulin dimers, inhibiting assembly of microtubule structures & arresting mitosis in metaphase (inhibiting DNA synthesis)

24

Indications for Vincristine

non-Hodgkins, ALL

25

Drug class for Paclitaxel

-Taxanes

 

26

MoA for Paclitaxel

-Inhibiting assembly of microtubule structures, arresting chromosome segregation & cell division

--inhibits DNA synthesis by inhibiting formation of the mitotic spindle in the "M" phase

27

Indications for Paclitaxel

-ovarian, breast, lung, bladder, prostate, melanoma, esophageal, Kaposi's sarcoma

*not leukemias & lymphomas

28

Drug class for Doxorubicine

Antitumor antibiotics

29

MoA for Doxorubicin

-interacts w/ DNA binding macromolecular biosynthesis

-inhibits topoisomerase II

-unclear bu inhibits DNA synthesis

30

Indications for Doxorubicin

leukemia, Hodgkin's, bladder, breast, stomach, lung, ovaries, thyroid, sarcoma, multiple myeloma