Psych Flashcards Preview

Pharmacology > Psych > Flashcards

Flashcards in Psych Deck (15):
1

What is the major first generation antipsychotic?

Haloperidol

2

What is the major second generation antipsychotic?

Risperidone

3

Can neural circuits 'learn' over time?

yes

4

Over-stimulated circuits become ______

dysregulated

5

What does an agonist do?

stimulate receptors

6

What do partial agonists do?

stimulate w/ ceiling & occupy receptor

7

What do antagonists do?

block agonist from receptor

8

What do inverse agonists do?

block agonists at receptor & reduce activity below baseline contitutive activity

9

What are some adverse reactions of antipsychotics?

extrapyramidal syndrome

tardive dyskinesias

neuroleptic malignant syndrome

serotonin syndrome

malignant hypertension

10

What is extrapyramidal syndrome?

excess stimulation of the portions of the CNS that controls motor function that is outside of the pyramidal tract

11

What is tardive dyskinesia?

late appearing dyskinesias

primarily orofacial dyskinesia

12

What is serotonin syndrome?

excess levels of 5HT producing akithesia, muscle twitching, hyper-reflexia, penile erection, seizures, coma

13

What is neuroleptic malignant syndrome?

excess antagonism of D2 receptor producing muscle rigidity, fever, unstable BP, myoglobinemia; may be fata

extreme manifestation of EPS

14

What is malignant hypertension?

genetically determined hypersensitivity to anesthetic agents resulting in severe hyperthermia, accelerated muscle mtabolism, metabolic acidosis

15