What is the major first generation antipsychotic?
What is the major second generation antipsychotic?
Can neural circuits 'learn' over time?
Over-stimulated circuits become ______
What does an agonist do?
What do partial agonists do?
stimulate w/ ceiling & occupy receptor
What do antagonists do?
block agonist from receptor
What do inverse agonists do?
block agonists at receptor & reduce activity below baseline contitutive activity
What are some adverse reactions of antipsychotics?
neuroleptic malignant syndrome
What is extrapyramidal syndrome?
excess stimulation of the portions of the CNS that controls motor function that is outside of the pyramidal tract
What is tardive dyskinesia?
late appearing dyskinesias
primarily orofacial dyskinesia
What is serotonin syndrome?
excess levels of 5HT producing akithesia, muscle twitching, hyper-reflexia, penile erection, seizures, coma
What is neuroleptic malignant syndrome?
excess antagonism of D2 receptor producing muscle rigidity, fever, unstable BP, myoglobinemia; may be fata
extreme manifestation of EPS
What is malignant hypertension?
genetically determined hypersensitivity to anesthetic agents resulting in severe hyperthermia, accelerated muscle mtabolism, metabolic acidosis