Psych

Question 1

What is the major first generation antipsychotic?

Answer 1

Haloperidol

Question 2

What is the major second generation antipsychotic?

Answer 2

Risperidone

Question 3

Can neural circuits ‘learn’ over time?

Answer 3

yes

Question 4

Over-stimulated circuits become ______

Answer 4

dysregulated

Question 5

What does an agonist do?

Answer 5

stimulate receptors

Question 6

What do partial agonists do?

Answer 6

stimulate w/ ceiling & occupy receptor

Question 7

What do antagonists do?

Answer 7

block agonist from receptor

Question 8

What do inverse agonists do?

Answer 8

block agonists at receptor & reduce activity below baseline contitutive activity

Question 9

What are some adverse reactions of antipsychotics?

Answer 9

extrapyramidal syndrome

tardive dyskinesias

neuroleptic malignant syndrome

serotonin syndrome

malignant hypertension

Question 10

What is extrapyramidal syndrome?

Answer 10

excess stimulation of the portions of the CNS that controls motor function that is outside of the pyramidal tract

Question 11

What is tardive dyskinesia?

Answer 11

late appearing dyskinesias

primarily orofacial dyskinesia

Question 12

What is serotonin syndrome?

Answer 12

excess levels of 5HT producing akithesia, muscle twitching, hyper-reflexia, penile erection, seizures, coma

Question 13

What is neuroleptic malignant syndrome?

Answer 13

excess antagonism of D2 receptor producing muscle rigidity, fever, unstable BP, myoglobinemia; may be fata

extreme manifestation of EPS

Question 14

What is malignant hypertension?

Answer 14

genetically determined hypersensitivity to anesthetic agents resulting in severe hyperthermia, accelerated muscle mtabolism, metabolic acidosis