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Flashcards in Neuro Deck (72):
1

Drug class for Lamotrigine

anti-seizure drug

2

MoA for Lamotrigine

blocks sustained repetitive neurone firing & prolongs inactivations of Na channels & probably Ca channels

3

Indications for Lamotrigine

mono or add-on therapy for generalized or partial seizures

4

Drug class for Carbamazepine

anti-seizure drug

5

MoA for Carbamazepine

decrease synaptic release glutamate, inhibits Na channels

6

Indications for Carbamazepine

generalized tonic-clonic & partial seizures

7

Drug class for Phenytoin

anti-seizure drug

8

MoA for Phenytoin

limits repetitive firing of neurons, inhibits Na channels

9

Indications for Phenytoin

partial & generalized tonic-clonic seizures

10

Drug class for Ethosuximide

anti-seizure drug

11

MoA for Ethosuximide

reduces low threshold Ca currents

12

Indications for Ethosuximide

petit mal or absence seizures in children

13

Drug class for Topiramate

anti-seizure drug

14

MoA for Topiramate

reduces voltage-gated Na currents, enhancesGABAa receptor currents, inhibits glutamate receptor

15

Indications for Topiramate

generalized tonic-clonic, partial, absence, migraines, HAs

16

Drug class for Valproic Acid

anti-seizure drug

17

MoA for Valproic Acid

increase concentration GABA pre & post-synaptive sites

18

Indications for Valproic Acid

seizures, primary generalized tonic-clonic, absence, myoclonic, tonic, mania, mood stabilization, migraine Px

19

Drug class for Lorazepam

benzodiazepine

20

MoA for Lorazepam

potentiates GABAa receptor

21

Indications for Lorazepam

anxiety, operative amnesia, status epilepticus

22

Drug class for Donepezil

alzheimer's disease: AChE inhibitors

23

MoA for Donepezil

inhibits activity of acetylcholinesterase thereby raising acetylcholine concentration in hippocampus

24

Indications for Donepezil

mild to moderate dementia of the Alzheimers type

25

Drug class for Memantine

alzheimer's disease: NMDA receptor antagonist

26

MoA for Memantine

blocks NMDA receptor prevention Ca ion influx via the NMDA receptor

27

Indications for Memantine

moderate to severe dementia of the Alzheimers type

28

Drug class for Levodopa/Carbidopa

dopamine

29

MoA for Levodopa/Carbidopa

elevates CNS dopamine levels

30

Indications for Levodopa/Carbidopa

Parkinson's disease

31

Drug class for Benztropine

anticholinergic

32

MoA for Benztropine

ACh receptor inhibition

33

Indications for Benztropine

Parkinson's disease, extrapyramidal symptoms

34

Drug class for Amantadine

NMDA receptor antagonist

35

MoA for Amantadine

decreases Levodopa injury to NMDA receptor

36

Indications for Amantadine

mild PD symptoms

37

Drug class for Selegiline

MAO-B Inhibitors

38

MoA for Selegiline

at therapeutic doses for PD, inhibits MAO-B enzyme w/ resulting rise in available dopamine in CNS

39

Indications for Selegiline

Parkinson's disease, depression

40

Drug class for Ropinirole

dopamine agonists

41

MoA for Ropinirole

stimulates D3 receptor directly

42

Indications for Ropinirole

Parkinson's disease, restless leg syndrome

43

Drug class for Entacapone

COMT inhibitors

44

MoA for Entacapone

COMT enzyme inhibition resulting in higher concentration dopamine in CNS; used in combo w/ Levodopa

45

Indications for Entacapone

Parkinson's disease

46

Drug class for Glatiramer Acetate

glatiramir

47

MoA for Glatiramer Acetate

blocks activation of T cells, activates Th2 cells

48

Indications for Glatiramer Acetate

RR MS

49

Drug class for Interferon B-1a

beta interferon

50

MoA for Interferon B-1a

decrease T cell activation; promotion of Th2 cells; decrease microglial proliferation; suppress of MMPs maintaining BBB

51

Indications for Interferon B-1a

RR MS

52

Drug class for Fingolimod

S1P receptor modulator

53

MoA for Fingolimod

acts to retain T cells in lymphoid tissues depleting peripheral blood & CNS lymphocytes

54

Indications for Fingolimod

relapsing forms of MS

55

Drug class for Natalizumab

Selective adhesion molecule inhibitor

56

MoA for Natalizumab

prevents lymphocyte migration into CNS & decreases activation of lymphocytes already in CNS

57

Indications for Natalizumab

relapsing forms of MS; moderate to severe Crohn's disease

58

Drug class for Dimethyl Fumerate

MS meds: Nrf2 activator

59

MoA for Dimethyl Fumerate

unknown but believed to arise form activation of anti-oxidative stress pathways

60

Indications for Dimethyl Fumerate

RR MS

61

Drug class for Baclofen

MS meds: antispasticity

62

MoA for Baclofen

agonist at GABA receptors producing hyperpolarization & pre-synaptic inhibition

63

Indications for Baclofen

muscle spasticity in MS or spinal cord lesions

64

Drug class for Dantrolene

MS meds: antispasticity

65

MoA for Dantrolene

blocks RyR1 Ca channel in sarcoplasmic reticulum of muscle fiber; especially rapid contraction fibers

66

Indications for Dantrolene

upper motor neuron muscle spasticity; malignant hyperthermia

67

Drug class for Elitriptatn and Sumatriptan

migraine meds: triptans

68

MoA for Elitriptan and Sumatriptan

activation of trigeminal pre-synaptic 5HT1D/1B receptors inhibits release of CGRP & is vasoconstriction

69

Indications for Elitriptan and Sumatriptan

migraine HA with or without aura

70

Drug class for Propanolol

migraine med: prophylaxis

71

MoA for Propanolol

nonselective B1 & B2 blocker

72

Indications for Propanolol

migraine prophylaxis; multiple others