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Pharmacology > Neuro > Flashcards

Neuro Flashcards

1
Q

Drug class for Lamotrigine

A

anti-seizure drug

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2
Q

MoA for Lamotrigine

A

blocks sustained repetitive neurone firing & prolongs inactivations of Na channels & probably Ca channels

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3
Q

Indications for Lamotrigine

A

mono or add-on therapy for generalized or partial seizures

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4
Q

Drug class for Carbamazepine

A

anti-seizure drug

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5
Q

MoA for Carbamazepine

A

decrease synaptic release glutamate, inhibits Na channels

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6
Q

Indications for Carbamazepine

A

generalized tonic-clonic & partial seizures

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7
Q

Drug class for Phenytoin

A

anti-seizure drug

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8
Q

MoA for Phenytoin

A

limits repetitive firing of neurons, inhibits Na channels

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9
Q

Indications for Phenytoin

A

partial & generalized tonic-clonic seizures

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10
Q

Drug class for Ethosuximide

A

anti-seizure drug

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11
Q

MoA for Ethosuximide

A

reduces low threshold Ca currents

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12
Q

Indications for Ethosuximide

A

petit mal or absence seizures in children

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13
Q

Drug class for Topiramate

A

anti-seizure drug

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14
Q

MoA for Topiramate

A

reduces voltage-gated Na currents, enhancesGABAa receptor currents, inhibits glutamate receptor

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15
Q

Indications for Topiramate

A

generalized tonic-clonic, partial, absence, migraines, HAs

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16
Q

Drug class for Valproic Acid

A

anti-seizure drug

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17
Q

MoA for Valproic Acid

A

increase concentration GABA pre & post-synaptive sites

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18
Q

Indications for Valproic Acid

A

seizures, primary generalized tonic-clonic, absence, myoclonic, tonic, mania, mood stabilization, migraine Px

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19
Q

Drug class for Lorazepam

A

benzodiazepine

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20
Q

MoA for Lorazepam

A

potentiates GABAa receptor

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21
Q

Indications for Lorazepam

A

anxiety, operative amnesia, status epilepticus

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22
Q

Drug class for Donepezil

A

alzheimer’s disease: AChE inhibitors

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23
Q

MoA for Donepezil

A

inhibits activity of acetylcholinesterase thereby raising acetylcholine concentration in hippocampus

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24
Q

Indications for Donepezil

A

mild to moderate dementia of the Alzheimers type

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25
Q

Drug class for Memantine

A

alzheimer’s disease: NMDA receptor antagonist

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26
Q

MoA for Memantine

A

blocks NMDA receptor prevention Ca ion influx via the NMDA receptor

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27
Q

Indications for Memantine

A

moderate to severe dementia of the Alzheimers type

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28
Q

Drug class for Levodopa/Carbidopa

A

dopamine

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29
Q

MoA for Levodopa/Carbidopa

A

elevates CNS dopamine levels

30
Q

Indications for Levodopa/Carbidopa

A

Parkinson’s disease

31
Q

Drug class for Benztropine

A

anticholinergic

32
Q

MoA for Benztropine

A

ACh receptor inhibition

33
Q

Indications for Benztropine

A

Parkinson’s disease, extrapyramidal symptoms

34
Q

Drug class for Amantadine

A

NMDA receptor antagonist

35
Q

MoA for Amantadine

A

decreases Levodopa injury to NMDA receptor

36
Q

Indications for Amantadine

A

mild PD symptoms

37
Q

Drug class for Selegiline

A

MAO-B Inhibitors

38
Q

MoA for Selegiline

A

at therapeutic doses for PD, inhibits MAO-B enzyme w/ resulting rise in available dopamine in CNS

39
Q

Indications for Selegiline

A

Parkinson’s disease, depression

40
Q

Drug class for Ropinirole

A

dopamine agonists

41
Q

MoA for Ropinirole

A

stimulates D3 receptor directly

42
Q

Indications for Ropinirole

A

Parkinson’s disease, restless leg syndrome

43
Q

Drug class for Entacapone

A

COMT inhibitors

44
Q

MoA for Entacapone

A

COMT enzyme inhibition resulting in higher concentration dopamine in CNS; used in combo w/ Levodopa

45
Q

Indications for Entacapone

A

Parkinson’s disease

46
Q

Drug class for Glatiramer Acetate

A

glatiramir

47
Q

MoA for Glatiramer Acetate

A

blocks activation of T cells, activates Th2 cells

48
Q

Indications for Glatiramer Acetate

A

RR MS

49
Q

Drug class for Interferon B-1a

A

beta interferon

50
Q

MoA for Interferon B-1a

A

decrease T cell activation; promotion of Th2 cells; decrease microglial proliferation; suppress of MMPs maintaining BBB

51
Q

Indications for Interferon B-1a

A

RR MS

52
Q

Drug class for Fingolimod

A

S1P receptor modulator

53
Q

MoA for Fingolimod

A

acts to retain T cells in lymphoid tissues depleting peripheral blood & CNS lymphocytes

54
Q

Indications for Fingolimod

A

relapsing forms of MS

55
Q

Drug class for Natalizumab

A

Selective adhesion molecule inhibitor

56
Q

MoA for Natalizumab

A

prevents lymphocyte migration into CNS & decreases activation of lymphocytes already in CNS

57
Q

Indications for Natalizumab

A

relapsing forms of MS; moderate to severe Crohn’s disease

58
Q

Drug class for Dimethyl Fumerate

A

MS meds: Nrf2 activator

59
Q

MoA for Dimethyl Fumerate

A

unknown but believed to arise form activation of anti-oxidative stress pathways

60
Q

Indications for Dimethyl Fumerate

A

RR MS

61
Q

Drug class for Baclofen

A

MS meds: antispasticity

62
Q

MoA for Baclofen

A

agonist at GABA receptors producing hyperpolarization & pre-synaptic inhibition

63
Q

Indications for Baclofen

A

muscle spasticity in MS or spinal cord lesions

64
Q

Drug class for Dantrolene

A

MS meds: antispasticity

65
Q

MoA for Dantrolene

A

blocks RyR1 Ca channel in sarcoplasmic reticulum of muscle fiber; especially rapid contraction fibers

66
Q

Indications for Dantrolene

A

upper motor neuron muscle spasticity; malignant hyperthermia

67
Q

Drug class for Elitriptatn and Sumatriptan

A

migraine meds: triptans

68
Q

MoA for Elitriptan and Sumatriptan

A

activation of trigeminal pre-synaptic 5HT1D/1B receptors inhibits release of CGRP & is vasoconstriction

69
Q

Indications for Elitriptan and Sumatriptan

A

migraine HA with or without aura

70
Q

Drug class for Propanolol

A

migraine med: prophylaxis

71
Q

MoA for Propanolol

A

nonselective B1 & B2 blocker

72
Q

Indications for Propanolol

A

migraine prophylaxis; multiple others

Pharmacology (16 decks)

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