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Neuro Flashcards

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1
Q

Drug class for Lamotrigine

A

anti-seizure drug

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2
Q

MoA for Lamotrigine

A

blocks sustained repetitive neurone firing & prolongs inactivations of Na channels & probably Ca channels

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3
Q

Indications for Lamotrigine

A

mono or add-on therapy for generalized or partial seizures

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4
Q

Drug class for Carbamazepine

A

anti-seizure drug

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5
Q

MoA for Carbamazepine

A

decrease synaptic release glutamate, inhibits Na channels

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6
Q

Indications for Carbamazepine

A

generalized tonic-clonic & partial seizures

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7
Q

Drug class for Phenytoin

A

anti-seizure drug

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8
Q

MoA for Phenytoin

A

limits repetitive firing of neurons, inhibits Na channels

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9
Q

Indications for Phenytoin

A

partial & generalized tonic-clonic seizures

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10
Q

Drug class for Ethosuximide

A

anti-seizure drug

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11
Q

MoA for Ethosuximide

A

reduces low threshold Ca currents

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12
Q

Indications for Ethosuximide

A

petit mal or absence seizures in children

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13
Q

Drug class for Topiramate

A

anti-seizure drug

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14
Q

MoA for Topiramate

A

reduces voltage-gated Na currents, enhancesGABAa receptor currents, inhibits glutamate receptor

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15
Q

Indications for Topiramate

A

generalized tonic-clonic, partial, absence, migraines, HAs

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16
Q

Drug class for Valproic Acid

A

anti-seizure drug

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17
Q

MoA for Valproic Acid

A

increase concentration GABA pre & post-synaptive sites

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18
Q

Indications for Valproic Acid

A

seizures, primary generalized tonic-clonic, absence, myoclonic, tonic, mania, mood stabilization, migraine Px

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19
Q

Drug class for Lorazepam

A

benzodiazepine

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20
Q

MoA for Lorazepam

A

potentiates GABAa receptor

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21
Q

Indications for Lorazepam

A

anxiety, operative amnesia, status epilepticus

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22
Q

Drug class for Donepezil

A

alzheimer’s disease: AChE inhibitors

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23
Q

MoA for Donepezil

A

inhibits activity of acetylcholinesterase thereby raising acetylcholine concentration in hippocampus

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24
Q

Indications for Donepezil

A

mild to moderate dementia of the Alzheimers type

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25
Drug class for Memantine
alzheimer's disease: NMDA receptor antagonist
26
MoA for Memantine
blocks NMDA receptor prevention Ca ion influx via the NMDA receptor
27
Indications for Memantine
moderate to severe dementia of the Alzheimers type
28
Drug class for Levodopa/Carbidopa
dopamine
29
MoA for Levodopa/Carbidopa
elevates CNS dopamine levels
30
Indications for Levodopa/Carbidopa
Parkinson's disease
31
Drug class for Benztropine
anticholinergic
32
MoA for Benztropine
ACh receptor inhibition
33
Indications for Benztropine
Parkinson's disease, extrapyramidal symptoms
34
Drug class for Amantadine
NMDA receptor antagonist
35
MoA for Amantadine
decreases Levodopa injury to NMDA receptor
36
Indications for Amantadine
mild PD symptoms
37
Drug class for Selegiline
MAO-B Inhibitors
38
MoA for Selegiline
at therapeutic doses for PD, inhibits MAO-B enzyme w/ resulting rise in available dopamine in CNS
39
Indications for Selegiline
Parkinson's disease, depression
40
Drug class for Ropinirole
dopamine agonists
41
MoA for Ropinirole
stimulates D3 receptor directly
42
Indications for Ropinirole
Parkinson's disease, restless leg syndrome
43
Drug class for Entacapone
COMT inhibitors
44
MoA for Entacapone
COMT enzyme inhibition resulting in higher concentration dopamine in CNS; used in combo w/ Levodopa
45
Indications for Entacapone
Parkinson's disease
46
Drug class for Glatiramer Acetate
glatiramir
47
MoA for Glatiramer Acetate
blocks activation of T cells, activates Th2 cells
48
Indications for Glatiramer Acetate
RR MS
49
Drug class for Interferon B-1a
beta interferon
50
MoA for Interferon B-1a
decrease T cell activation; promotion of Th2 cells; decrease microglial proliferation; suppress of MMPs maintaining BBB
51
Indications for Interferon B-1a
RR MS
52
Drug class for Fingolimod
S1P receptor modulator
53
MoA for Fingolimod
acts to retain T cells in lymphoid tissues depleting peripheral blood & CNS lymphocytes
54
Indications for Fingolimod
relapsing forms of MS
55
Drug class for Natalizumab
Selective adhesion molecule inhibitor
56
MoA for Natalizumab
prevents lymphocyte migration into CNS & decreases activation of lymphocytes already in CNS
57
Indications for Natalizumab
relapsing forms of MS; moderate to severe Crohn's disease
58
Drug class for Dimethyl Fumerate
MS meds: Nrf2 activator
59
MoA for Dimethyl Fumerate
unknown but believed to arise form activation of anti-oxidative stress pathways
60
Indications for Dimethyl Fumerate
RR MS
61
Drug class for Baclofen
MS meds: antispasticity
62
MoA for Baclofen
agonist at GABA receptors producing hyperpolarization & pre-synaptic inhibition
63
Indications for Baclofen
muscle spasticity in MS or spinal cord lesions
64
Drug class for Dantrolene
MS meds: antispasticity
65
MoA for Dantrolene
blocks RyR1 Ca channel in sarcoplasmic reticulum of muscle fiber; especially rapid contraction fibers
66
Indications for Dantrolene
upper motor neuron muscle spasticity; malignant hyperthermia
67
Drug class for Elitriptatn and Sumatriptan
migraine meds: triptans
68
MoA for Elitriptan and Sumatriptan
activation of trigeminal pre-synaptic 5HT1D/1B receptors inhibits release of CGRP & is vasoconstriction
69
Indications for Elitriptan and Sumatriptan
migraine HA with or without aura
70
Drug class for Propanolol
migraine med: prophylaxis
71
MoA for Propanolol
nonselective B1 & B2 blocker
72
Indications for Propanolol
migraine prophylaxis; multiple others

Pharmacology (16 decks)

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