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Flashcards in Restrictive Lung Diseases Deck (14):

What is Restrictive lung disease

It is difficult with breathing in. The O2 levels are low but the CO2 levels are low and this making the pH high or Alkaline (respiratory Alkalosis)


What are categories of the Restrictive lung disease

Hyperventilation, Alkalosis, anxiety, stress,hysteria, pain, High Altitude, Amiodarone,Bleomycin, Busulphan, cyclophosphamide, Methotrexate, Pregnancy, Pulmonary Embolism, Aspirin, all autoimmune and Neuromuscular diseases with fever, stroke, hepatic failure


What are the different types of Restrictive Lung disease

ILD, Pneumoconiosis, Sarcoidosis, hypersensitivity Pneumonitis and Drug induces


What in ILD

inflammatory and or fibrosing process in the alveolar walls. they are distortion and destruction of normal alveoli and micro-vasculture. interstitial issue.


What are the manifestations of ILD

SOB, Non Productive Cough, Crackles, clubbing and Right hight failure


What is pneumoconiosies? What are the types?

environmental dust particle cause interstitial fibrosis. can be associated with the occupation of the patient.
Coal Worker - Berylliosis
Silicosis - Tb infection
Asbestosis - Bronchogenic and Mesothelioma


What is Sarcoidosis

Multi-system granulomatous disease. It is a noncaseating granuloma in multiple tissues and organs. it is common in middle aged african american women that is non-smoker or scadinavian descent.


What will you see with Sarcoidosis

Asteroid and schaumman bodies


What is the pathogenesis of Sarcoidosis

Intra-alveolar and interstitial accumulation of CD4+ and Th1 cells. Increases in T cell–derived TH1 Cytokines (IL-2 , IFN-γ…) →T Cell Expansion and Macrophage Activation.Increases in Cytokines in the Local Environment (IL-8, TNF, Macrophage Inflammatory Protein-1α) Favor Recruitment of T cells and Monocytes that contribute to the Formation of Granulomas. Hypercalcemia, Hypercalciuria Caused by Increased Calcium Absorption Secondary to Production of Active Vitamin D (increased synthesis of 1-alpha-hydroxylase.


What is the chest x-ray of a person with sarcoidosis

bilateral hilar lymphadenopathy


What are skin lesions of sarcoidosis

eyrthema nodosum.


What is hypersensitivity Pneumonitis

Exposure to known inhaled antigen


What are the types of hypersensitivity pneumonitis

Farmer's Lungs: Thermo actinomycetes
Bird feeder lung: C. psittaci
Humidifier Lung: A. Pollulans
Sauna Takers: Aurebasidium species


What are the manifestations of Hypersensitivity pneumonitis

Acute SOB, cough, fever and chills