Rhematoid arthritis Flashcards
(16 cards)
rheomdi arthisi maily effects gedner -
females
rhemodia rhteirs is linked to which gens
hla - drb1
rheoid arthis mily effects joint
small joints of hands mcp and pip - not dip
and feet mtps
risk factors for rheoid is
ciggarte spoke
virus - perioddonal disase, ebv an parvovirus b19
eary age of menopase
low tesore levels in men
ra sympos re
pain
moring stiffnes for more than 30 min
immobity
poor fucniton
systemic sympaoms
ra signs are
swelling
tendorness
warth
redenss
limiation of movement
synovitis early signs are
inflamation of joints
rheumatoid hands are found in
adanved disase
extra articualr symotmos are
fatiuqe, aneam, lung, eyes, nerves and skin involvement, weight loss,
long term
cvs and malignay risk
investion for rhoid arthis si
baseline bloods
immoblif - rhoid ffacoer, anti cyclic cituliated antioic - anti ccp - 99% specific but can be postive before disase
wrist exray for athis show
bone eerrosio and fuion of carpa bone
assesm for ra is
das 28
a score of das 28 above and belwo are signan
above 5 .1 - bioloicl therap y
beofew 2. 6 rpesent clicla remision
mangeme of ra is
nsaisis -
glucocotiostie - pernoiley, hyocoide, prednolone
convetial systiemic - dmards - metotexate, hydoroclyoide,
biologoics - tnf inhiotrs - end in mab
targed systemic dmards
bioloci therpay for ra is
tnfa inhor
il inhot
anti b clle
anti t cell
il 6 inhoors
oral kinase inhitors
bioloic side effects are
injectio site reactino
increased malignaty risk
extremly high cost
