Study Guide 4

Question 1

Where is the pancreas located?

Answer 1

• deep to stomach
• stretches across abdomen
• head adjacent to duodenum
• tail adjacent to spleen

Question 2

Pancreas: 2 major tissue types

Answer 2

• acini

- islets of Langerhaans

Question 3

Pancreas: ancini function

Answer 3

• exocrine

- secrete digestive juices into duodenum

Question 4

Pancreas: islets of langerhaans (function)

Answer 4

• endocrine

- secrete insulin and glucagon directly into the blood

Question 5

What types of cells are contained in the Islets of Langerhaans?

Answer 5

• Beta cells
• Alpha cells
• Delta cells
• PP cells

Question 6

Islets of Langerhaans: composition % of cells

Answer 6

• Beta: 60%
• Alpha: 25%
• Delta: 10%
• PP cells: very few

Question 7

Islets of Langerhaans: location of beta cells

Answer 7

In the middle of islet

Question 8

Islets of Langerhaans: What do beta cells do?

Answer 8

Secrete insulin and amylin

Question 9

What does insulin do?

Answer 9

• facilitates entrance of glucose into cells

» lowers blood glucose

Question 10

Islets of Langerhaans: What does amylin do?

Answer 10

Inhibits insulin secretion

Question 11

Islets of Langerhaans: What do alpha cells secrete?

Answer 11

Glucagon

Question 12

Islets of Langerhaans: glucagon

Answer 12

increases blood glucose levels by stimulating the liver and other storage cells to release glucose

Question 13

Islets of Langerhaans: What do delta cells secrete?

Answer 13

Somatostatin

Question 14

What does somatostatin do?

Answer 14

Helps regulate release of insulin and glucagon

Question 15

What do PP cells do?

Answer 15

Secrete a hormone “pancreatic polypeptide”

Question 16

What does insulin do to glucagon?

Answer 16

Insulin inhibits glucagon secretion

Question 17

What does amylin inhibit?

Answer 17

Amylin inhibits insulin secretion

Question 18

What does somatostatin inhibit?

Answer 18

Secretion of both insulin and glucagon