Toxicology Emergencies Flashcards

(88 cards)

1
Q

4 primary methods of entry

A

Ingestion
Inhalation
Injection
Absorption

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2
Q

Assessment clues pointing towards ingestion:

A

Stained fingers, lips, or tongue
Sudden onset of stomach cramps w/, w/o n/v/d
Empty pill bottles
Plant partially chewed

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3
Q

Management of ingestion toxicology

A
Immediately assess ABCs
Activated charcoal or syrup of ipecac
Prompt transport to ED
Possible IV access
Provide aggressive vent support and CPR if ingestion of opiate, sedative or barbiturate
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4
Q

Assessment clues pointing towards inhalation

A

Rapid onset of s/s

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5
Q

Management of inhalation toxicology

A
Scene Safety
Consult poison control or local hazardous materials team members
Remove clothing
Take any containers with you
High concentration of oxygen
Iv access
Pulse ox
Call ALS backup early
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6
Q

Why should you never pull a shirt over the pt’s head?

A

The toxin can be introduced in the eye, nose or mouth. Always cut or unbutton.

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7
Q

Management of injection posioning

A
Monitor airway
Administer high-flow oxygen
Be alert for n/v
Transport promptly 
Take all containers with you
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8
Q

s/s of absorption poisoning

A

Hx of exposure
Liquid or powder of skin
Burns, itching, irritation or redness of skin
Typical odors of the substance

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9
Q

Management of absorption poisoning

A

Avoid contamination
Remove irritating or corrosive substances from pt
Cut off all clothing
Brush off as much powder, flush skin with running water, and then wash with soap and water
Irrigates eyes for 20 minutes if needed
Obtain material SDS
Prompt transport
Continue irrigation and oxygen if possible while enroute

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10
Q

Why should you never flush off dry powder?

A

Water can activate a chemical reaction.

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11
Q

What type of chemicals react violently with water?

A

Phosphorus or elemental sodium

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12
Q

Major toxidromes

A
Stimulants
Narcotics
Sympathomimetics
Cholinergic
Anticholinergics
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13
Q

s/s of stimulant toxidrome

A
Restlessness
Agitation
Incessant talking
Insomnia
Anorexia
Dilated pupils
Tachycardia
Tachypnea
HTN or hypotension
Paranoia
Seizures
Cardiac arrest
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14
Q

Examples of stimulant toxidromes

A
Amphetamine
Methamphetamine
Cocaine
Diet aids
Nasal decongestants
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15
Q

s/s of narcotic toxidrome

A

Pinpoint pupils
Marked respiratory depression
Drowsiness
Stupor Coma

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16
Q

Examples of narcotic toxidromes

A
Heroin
Morphine
Hydromorphone
Fentanyl
Oxycodone
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17
Q

s/s of sympathomimetic toxidromes

A
Hypertension
Tachycardia
Dilated pupils
Agitation
Seizures
Hyperthermia
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18
Q

Examples of sympathomimetic toxidromes

A

Epi
Albuterol
Cocaine
Methamphetamine

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19
Q

s/s of sedative-hypnotic toxidrome

A
Drowsiness
Disinhibition
Ataxia
Slurred speech
Mental confusion
Resp. depression
Progressive CNS depression
Hypotension
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20
Q

Examples of sedative-hypnotic toxidrome

A

Diazepam
Secobarbital
Flunitrazepam

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21
Q

s/s of cholinergic toxidrome

A

SLUDGEM

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22
Q

Examples of cholinergic toxidromes

A

Diazonin
Orthene
Parathion
Nerve gas

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23
Q

s/s anticholinergic toxidrome

A
Tachycardia
Hyperthermia
Dry skin
Dry mucous membranes
Dilated pupils
Blurred vision
Sedation
Agitation
Seizures
Coma 
Delirium
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24
Q

Examples of anticholinergic toxidromes

A
Atropine
Antihistamines
Jimsonweed
Antipsychotics
Scopolamine
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25
Antagonist
Affinity for a cell receptor preventing the cell from responding.
26
Potentation
Enhances the effect of one drug by another
27
Synergism
The total effect of two drugs are greater than the sum of the independent effects of the two.
28
Dosage of activated charcoal
1g/kg Adults : 25-50 Children : 12.5 - 12.5
29
Contraindications of activate charcoal
Ingested acid, alkali, or petroleum product Decreased LOC Cannot protect their airways Unable to swallow
30
Minor alcohol withdrawal s/s
``` Restlessness Anxious Sleeping disturbances Agitation Tremors ```
31
Major ETOH withdrawal s/s
Increased BP Vomiting Hallucinations Delirium tremens
32
What is delirium tremens?
Delirium resulting in tremors, restlessness, weakness, fever, diaphoresis, disorientation, hallucinations, confusion, hypotension, seizures, and possibly death.
33
Medical conditions alcoholics are more susceptible to
``` Subdural hematoma GI bleeding Pancreatitis Hypoglycemia Burns Hypothermia Seizures Dysrhythmias Cancer Esophageal varices ```
34
Management of ETOH-related condistions
Establish and maintain airway Gag reflex present left lateral recumbent w/ suction ready Non gag reflex - airway adjunct and vent BVM High-concentration oxygen Vascular access Asses blood sugars Suspect internal bleeding if s/s shock
35
How can you protect a patient with DTs from injury?
``` Keep pt calm Administer oxygen via nasal cannula Vascular access Manage hypotension w/ infusion of nl saline Reassess breath sounds Maintain ongoing dialogue ```
36
When do withdrawal seizures typically occur?
w/in 12-48 hours of last drink
37
Narcotic
Drug that produces sleep or AMS
38
Two classifications of narcotics
Opiate - natural drugs derived from opium | Opioid - synthetics
39
Examples of common narcotics
``` Morphine Codein Heroin Fentanyl Oxycodone Meperidine Propoxyphene Dextromethorphan ```
40
Pathophysiology of narcotics
Major effects on the CNS by binding with receptor sites in the brain and other tissues
41
Naloxone dosage
0.4 - 2mg
42
What should you do before administering Naloxone?
Place OPA or NPA and vet w/ BVM
43
Onset of effects of snorting cocaine and smoking cocaine.
Nasal : effects w/ 1-2 minutes and peaks in 20-30 minutes | Inhalation : onset 8-10 seconds and does not last as long
44
What potentially fatal complications can occur with cocaine use?
``` Lethal dysrhythmias AMI Seizures CVA Apnea Hyperthermia ```
45
Management of stimulant OD
Maintain max oxygen levels Prevent seizures w/ adequate sedation Monitor serial vital signs IV access Manage hypotension w/ fluid infusion of nl saline Call ALS backup for medication administration of benzo
46
Smoking marijuana results in
``` Bronchodilation Slight tachycardia Euphoria Drowsiness Decreased short-term memory Diminished motor coordination Increased appetite Bloodshot eyes ```
47
Management of marijuana use
Supportive care
48
Adverse effects of spice
``` Psychosis Hallucinations Tachycardia Vomiting Renal problems Seizures ```
49
Management of spice OD
Supportive care w/ fluids and airway maintenance. | Call ALS if seizures occur for medication administration
50
Treatment for PCP or ketamine OD
``` Secure the patient well Assess ABCDEs Manage life threats Administer oxygen IV access Safe transport to facility Call ALS for benzo administration to help calm agitated pt ```
51
Treatment for mescaline or psilocybin mushrooms OC
``` Pay attention to ABCDEs Administer oxygen therapy Monitor vital signs Provide positive psychological support Provide safe transport IV access ```
52
Mild to moderate barbiturate intoxication s/s
``` Similar to ETOH intoxication Drowsiness Decreased inhibitions Ataxia Mental confusion Staggering gait ```
53
Increased doses of barbiturate intoxication s/s
Lethargic | Low level of responsiveness or unresponsiveness
54
Effects of beznodiazepines
Sedation Reduction of anxiety Relaxation of striated muscle
55
s/s benzodiazepines OD
``` AMS Drowsiness Confusion Slurred speech Ataxia General incoordination ```
56
Withdrawal s/s of benzodiazepines
Tachycardia Tremulousness Confusion Seizures
57
What medical conditions are commonly treated with benzodiazepines?
Anxiety, seizures, ETOH withdrawal
58
What medical conditions are commonly treated with barbiturates?
Sleep aids, antianxiety, seizures
59
Management of sedative-hypnotic OD
Airway management first priority Administer high-concentration oxygen IV access Shock - rapid infusion of 20-mL/kg bolus of nl saline and repeated doses up to 2L PRN
60
s/s of cardiac drug OD
``` Hypotension Weakness or confusion N/V Rhythm disturbance Headache Difficulty breathing ```
61
Management of cardiac drug OD
``` Patent airway Adequate vent Administer high-flow oxygen IV access Sequential fluid boluses of nl saline for HTN Contact medical control ```
62
Major classes of cardiac drugs
``` Antidysrhythmics Beta-blockers Calcium-channel blockers Cardiac-channel blockers Cardiac glycosides Angiotensin-converting enzyme inhibitors ```
63
s/s tricyclic antidepressant OD
``` AMS Dysrhythmias Dry mouth Blurred vision or dilated pupils Urinary retention Constipation Pulmonary edema ```
64
Management of TCAs OD
Maintain airway. Insert advanced airway if deterioration Call ALS for cardiac monitoring, intubation, and medication administration. Administer high-flow supplemental oxygen IV access Administer activated charcoal per medical control Manage hypotension with boluses of nl saline Assess blood sugars. Administer dextrose 50% in water.
65
Early and late s/s of MOAI OD
Hyperactivity Sinus tachycardia Hyperventilation Nystagmus ``` Chest pain Palpitations HTN Diaphoresis Agitate or combative behavior Hyperthermia Hallucinations ```
66
Management of MAOI OD
Establish and maintain airway Administer high-flow oxygen or provided positive pressure vent IV access Consider activate charcoal if recommended by medical control Treat HTN with fluid boluses of nl saline Call ALS for seizures to administer medications
67
s/s SSRI OD
``` N/V Sinus tachycardia Sedation Tremors Dilated pupils Agitation BP changes Seizures Hallucinations ```
68
Management of SSRI OD
``` Establish and maintain airway Administer high-flow oxygen IV access Call ALS PRN Consider single dose of activated charcoal ```
69
s/s lithium OD
N/V Hand tremors Excessive thirst Slurred speech ``` Ataxia Muscle weakness Incoordination Blurred vision Hyperreflexia Seizures Coma ```
70
Management of lithium OD
Establish and maintain airway, insert advanced airway if needed. Administer high-flow oxygen IV access Administer serial boluses of nl saline if hypotensive
71
s/s NSAID OD
``` Headache AMS Behavioral changes Seizures Bradydysrythmias Hypotension ABD pain N/V ```
72
Management of NSAID OD
Establish and maintain airway, insert advanced airway if needed Administer high-flow oxygen IV access Administer fluid bolus of nl saline if hypotensive Consider ALS if hypotension continues
73
s/s salicylates OD
``` N/V ABD pain Diaphoresis Hyperpnea Tinnitus Pulmonary edema Acid-base disturbances ``` Metabolic acidosis Respiratory alkalosis-metabolic acidosis
74
Management of salicylates OD
Establish and maintain airway, insert advanced airway PRN Administer high-flow oxygen IV access Administer serial boluses of nl saline if hypotensive Monitor CO2 levels One dose of activated charcoal after consulting medical control
75
Management of APAP OD
Administer high-flow oxygen IV access Recent ingestions - consider activate charcoal after medical control consult
76
s/s GHB OD
CNS depression Disinhibition Passivity Antegrade amnesia
77
Management of GHB
Establish and airway management, insert an advanced airway if needed Carefully monitor LOC Assist breathing as necessary and administer high-flow oxygen IV access Provide rapid transport
78
Pathophysiology of organophosphate poisoning
Overstimulate normal body functions controlled by parasympathetic nerves.
79
Management of organophosphate
``` Decontaminate and remove all clothing Establish and maintain the airway Suction PRN Administer high-flow oxygen IV access Call ALS for medication administration and cardiac monitoring. Transport immediately ```
80
Management of CO poisoning
Remove pt from environment Establish and maintain airway, insert advanced airway PRN Administer high0flow oxygen with tight-fitting nonrebreather IV access Keep patient quiet and rest Monitor LOC
81
Management of lead poisoning
Establish and maintain airway, inserting an advanced airway Administer high-flow oxygen IV access with saline or hep lock Only administer fluids if hypotensive
82
s/s lead poisoning
``` AMS Mood changes Memory deficit Sleep disturbances Headache Seizures Ataxia ABD pain Renal insufficiency HTN Gout Anemia ```
83
Management of iron poisoning
ABCs
84
s/s iron poisoning
ABD pain Vomiting Diarrhea Hypotension
85
s/s chlorine gas poisoning
Burning sensation of eyes, nose, and through with slight cough. ``` Chest tightness Choking Paroxysmal cough Headache N/V Diffuse wheezing Cyanosis Crackles Shock Seizures Loss of conscious ```
86
Management of chlorine gas poisoning
Remove from exposure Prioritize breathing Irrigate burning or itching eyes with water
87
s/s food poisoning
Abd pain and cramping | N/V/D
88
Management of food poisoning
Establish and maintain the airway, inserting advanced airway PRN Administer high flow oxygen IV access Fluid boluses w/ nl saline if hypotensive Call ALS for backup PRN