Viral hepatitis Flashcards Preview

Year 1 Microbiology > Viral hepatitis > Flashcards

Flashcards in Viral hepatitis Deck (46):
1

What is the key feature of fulminant hepatitis?

CNS effects

2

What virus family does Hep A belong to?

Picornavirus

3

What is the genome for Hep A?

+ssRNA

4

What is the incubation period for Hep A?

28 days

5

What is the association with Hep A and chronic and fulminant hepatitis?

1. Does not cause chronic hepatitis 2. Rarely causes fulminant hepatitis

6

What is the diagnosis for Hep A?

1. Acute - IgM against HAV 2. Anti-HAV IgG Abs seen in prior infections

7

What are the properties of the Hep A vaccine?

1. IM - 2 doses 2. HAVRIX and VAQTA

8

What are Dane particles?

Infectious particles seen in HBV infection

9

What are the properties of the tubes and spheres seen in HBV infection?

1. Incomplete, non-infectious 2. Indicate an active infection (Dane particles are present)

10

What virus family does hepatitis B belong to?

Hepadavirus

11

What is the Hep B genome?

1. Partially dsDNA 2. Reverse transcriptase is part of life cycle

12

What are the components of the Hep B infectious (Dane) particle?

1. Surface antigen 2. Core antigen 3. E antigen

13

What are the components of the Hep B non-infectious tubes and spheres?

Surface antigen only

14

What are the features of the Hep B core antigen?

1. Separates genome from surface antigen 2. Non-soluble - not seen in blood stream 3. Anti-HBcAg Abs detected diagnostically

15

What are the features of the Hep B e antigen?

1. Surrounds genome 2. Soluble - detectable in blood stream

16

What characterizes acute Hep B serology?

1. Surface antigen goes up early then drops upon clearance 2. Ab to surface Ag goes up as Ag disappears 3. Igm seen against core antigen initially, then IgG as it progresses

17

What characterizes chronic Hep B serology?

1. Surface antigen starts out high (similar to acute) 2. Maintenance of high surface Ag levels (different from acute) 3. Anti core Ag present but IgM goes down early 4. Primary Ab seen is IgG 5. Anti surface Ag Ab is not produced (key feature)

18

What is the key feature of chronic Hep B serology?

Anti-surface Ag antibody is not produced (recovery is not occurring)

19

What is the diagnosis for Hep B?

1. Viral antigens and anti-HBV Abs 2. Presence of HBsAg in blood

20

What can be used to differentiate between chronic and acute Hep B infection?

Presence of HBsAg in blood

21

If vaccinated against Hep B, antibody to what antigen would be seen?

HBsAg

22

What is the transmission route for Hep B?

Body fluids

23

What is the transmission route for Hep A?

Fecal-oral

24

Young age of Hep B infection is correlated with what type of risk of chronic infection later in life?

High risk

25

What are the treatments for chronic Hep B infection?

1. Lamivudine - reverse transcriptase inhibitor 2. Famcylovir / Adefovir dipivoxil - nucleoside inhibitor 3. Interferon-alpha

26

What is the Hep B vaccine composed of?

Purified HBsAg protein

27

What virus family does Hep C belong to?

Flavivirus

28

Is Hep C enveloped or non-enveloped?

Enveloped

29

What is the Hep C genome?

+ssRNA

30

What is the transmission for Hep C?

Bloodborne, body fluids

31

What is the diagnosis for Hep C?

1. Screening - Ab-based test for anti-HCV Abs 2. Confirmatory - nucleic acid based test for detection of viral genome

32

Hep C infection will develop into chronic infection what percentage of the time?

70%

33

What is the treatment for chronic genotype 1 Hep C?

1. Ledipasvir / sofosbuvir 2. Paritaprevir / ritonavir / ombitasvir / dasabuvir, ribavirin 3. Sofosbuvir and semiprevir and/or ribavirin

34

What is the treatment for chronic genotype 2 Hep C?

Sofosbuvir and ribavirin

35

What drug is common to all Hep C treatments?

Sofosbuvir

36

What is the Hep D genome?

Small circular ssRNA

37

What proteins cover the Hep D virion?

Delta-short and delta-long

38

What forms the external surface of the Hep D virion?

Hep B surface antigen

39

What does Hep D require to replicate?

HBV proteins - only infects cells that have previously been infected with HBV

40

What is the transmission for Hep D?

Body fluids

41

Fulminant hepatitis infection is a more likely outcome with what type of infection?

HBV and HDV coinfection

42

Which hepatitis virus directly injures hepatocytes?

Hep D

43

What is the diagnosis for Hep D?

ELISA to detect anti-HDV Abs or delta antigens

44

What virus family does Hep E belong to?

Hepevirus

45

What is the Hep E transmission route?

Fecal-oral

46

Does Hep E cause chronic infection?

No