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Year 1 Microbiology > GI viruses > Flashcards

Flashcards in GI viruses Deck (31):
1

What virus family does polio virus belong to?

Picornaviridae

2

What is the polio virus genome?

RNA

3

What is the transmission for polio virus?

Fecal-oral

4

Which polio vaccine does not have a risk for VAPP?

Inactivated

5

What are features of the live attenuated polio vaccine?

1. Trivalent 2. Replicates in GI tract 3. Shed in stool for 6 weeks following inoculation 4. 1/2mil vaccine doses revert to VAPP

6

How is viral gastroenteritis different from bacterial in terms of setting?

Viral gastroenteritis can occur in both developed and developing countries

7

How is viral gastroenteritis different from bacterial in terms of vomiting?

Prominent - can be only disttinguishing feature especially in children

8

How is viral gastroenteritis different from bacterial in terms of diarrhea?

Common - non-bloody in almost all cases

9

How is viral gastroenteritis different from bacterial in terms of diagnosis?

Often a diagnosis of exclusion

10

Rotavirus is most severe for what age group?

3-24 months

11

What is the genome for rotavirus?

dsDNA, segmented

12

What is the clinical presentation for rotavirus?

1. 1-3d incubation 2. Vomiting and diarrhea for 4-7d, occasional cough 3. 33% of patients have fever >102F 4. Typically infects 3-25mo patients 4. Malabsorptive diarrhea

13

What is the pathogenesis for rotavirus?

1.

14

What does the rotavirus NSP4 toxin do?

Induces calcium release

15

Which rotavirus toxin induces calcium release?

NSP4

16

What is the diagnosis for rotavirus?

1. EIA - looking for Abs to virus 2. EM, rtPCR

17

What are the rotavirus vaccines?

1. Rotateq 2. Rotatrix

18

What does the Rotateq vaccine protect against?

G1-G4, G9

19

How is the Rotateq vaccine made?

Reassortment between human and bovine rotaviruses

20

How is the Rotatrix vaccine made?

Live attenuated strain of human rotavirus G8

21

What age is recommended for the rotavirus vaccine?

Before 12 weeks

22

What are the clinical symptoms of norovirus?

1. Incubation 24-48h 2. Nausea, vomiting, diarrhea for 24-60h 3. 50% have low grade fever 4. Affects all age groups 5. Pathology similar to rotavirus

23

What virus family does norovirus belong to?

Caliciviridae

24

What is the norovirus genome?

+ssRNA

25

What is the transmission for norovirus?

Fecal-oral

26

What is the virulence for norovirus?

As few as 100 virions can infect

27

What is the genome for adenovirus?

dsDNA, naked capsid

28

Which adenovirus serotypes cause GI disease?

40 and 41

29

What are the clinical manifestations for adenovirus gastroenteritis?

1. 8-10d incubation 2. May have fever and vomiting 3. Watery, non-bloody diarrhea 7-8d 4. No seasonal variation 5. Primarily in children

30

What is the diagnosis for GI adenoviruses?

Looking for antigens to adenovirus in stool sample

31

What is the astrovirus genome?

+ssRNA