Zoonotic and vector borne infections Flashcards Preview

Year 1 Microbiology > Zoonotic and vector borne infections > Flashcards

Flashcards in Zoonotic and vector borne infections Deck (17):
1

What are the flaviviruses?

West Nile, Dengue, Yellow Fever, St. Louis Encephalitis

2

What percentage of people with WNV infection develop West Nile Fever?

20%

3

How is SLE transmitted?

Culex mosquitoes acquire disease from infected birds

4

What are the symptoms of severe SLE infection?

Headache, high fever, stiff neck, stupor, disorientation, coma, tremors, occasional convulsions, spastic paralysis

5

What are the togaviruses?

1. Eastern equine encephalitis (EEE) 2. Western equine encephalitis (WEC) 3. Venezuelan equine encephalitis (VEE)

6

What makes VEE different from EEE and WEE?

Most cases ARE symptomatic

7

What is the transmission for hantavirus?

Inhalation of dried feces and urine from infected rodents

8

What is the unique feature of LaCrosse encephalitis?

Maintained in natural life cycle in chipmunks and rodents

9

How is LaCrosse encephalitis transmitted?

Mosquitoes

10

LaCrosse encephalitis is mainly seen in what age group?

Children

11

What is the pathogenesis of rabies?

Virus proliferates locally, then heads to CNS - incubation of days to months then disseminates to peripheral nerves

12

What is the treatment for rabies?

Post-exposure prophylaxis - 1 does Ig and 5 doses vaccine over a 28 day period

13

What type of virus is lymphocytic choriomeningitis virus (LCMV)?

Arenavirus

14

What are the symptoms of lymphocytic choriomeningitis virus (LCMV)?

1. Rodent borne virus - causes aseptic meningitis, encephalitis, meningoencephalitis 2. Biphasic pattern of illness

15

How is LCMV spread?

Common house mouse - inhalation of infectious aerosolized particles of rodent urine, feces, saliva

16

How are PrPc and PrPsc different?

PrPc has numerous alpha helices, PrPsc has beta pleated sheets

17

What is the prion replication theory?

1. PrPsc binds to PrPc on normal cell 2. Normal cell converts to PrPsc 3. Aggregate fibrils form and are internalized by neurons 4. Neurons become vacuolated and amyloid plaques are deposited