Viral infections of skin and soft tissue II Flashcards Preview

Year 1 Microbiology > Viral infections of skin and soft tissue II > Flashcards

Flashcards in Viral infections of skin and soft tissue II Deck (40)
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1
Q

What type of lesion spread is seen in smallpox?

A

Centrifugal - mostly on face and extremities

2
Q

What are the features of the smallpox lesion?

A

Pustular / scabbing, firm to the touch

3
Q

What family does variola virus belong to?

A

Poxviridae

4
Q

What is the variola virus genome?

A

Large dsDNA

5
Q

Where does variola virus replicate?

A

Cytoplasm

6
Q

What virus is responsible for smallpox?

A

Variola virus

7
Q

What comprises the smallpox vaccine?

A

Live strain of a vaccinia virus (different poxviridae family member)

8
Q

How can smallpox be differentiated from chickenpox?

A

Smallpox lesions develop on hands and feet and are synchronous

9
Q

What are the 3 Cs associated with measles?

A

Cough, coryza, conjunctivitis

10
Q

What sign is pathognomonic for measles?

A

Koplik’s spots - small white spots with red borders opposite molars on oral mucosa

11
Q

How is the measles rash described?

A

Maculopapular, beginning at the hairline and spready downward

12
Q

What family does the measles virus belong to?

A

Paramyxoviridae

13
Q

What is the measles virus genome?

A

ssRNA

14
Q

Is the measles virus enveloped or non-enveloped?

A

Enveloped

15
Q

Which gene is important for fusion of measles virus?

A

F gene

16
Q

Which protein is important for attachment of measles virus?

A

HA protein

17
Q

What percentage of measles cases involve complications?

A

30%

18
Q

What type of vaccine is the measles vaccine?

A

Live attenuated

19
Q

When is the measles vaccine recommended?

A

12-15 months, then at 4-6 years

20
Q

How is the German measles rash described?

A

Maculopapular, appearing first on face then spreading downward - does not coalesce

21
Q

Which virus is responsible for German measles?

A

Rubella virus

22
Q

What are the symptoms of congenital rubella syndrome?

A

Deafness, cataracts, congenital glaucoma, congenital heart disease, pigmentary retinopathy, purpura, hepatosplenomegaly

23
Q

What family does the rubella virus belong to?

A

Togavirus

24
Q

Is the rubella virus enveloped or non-enveloped?

A

Enveloped

25
Q

What is the rubella virus genome?

A

RNA

26
Q

What type of vaccine is the rubella vaccine?

A

Live attenuated

27
Q

What are the symptoms of fifth disease / erythema infectiosum?

A

Fever, characteristic rash beginning on cheeks

28
Q

What virus is responsible for fifth disease?

A

Parvoviridae

29
Q

What is the fifth disease genome?

A

ssDNA

30
Q

Where does B19 parvovirus grow?

A

Exclusively in mitotically active cells

31
Q

What virus is responsible for fifth disease?

A

B19 parvovirus

32
Q

Where does B19 parvovirus live within the body?

A

Hematopoietic cells in bone marrow

33
Q

What are disease manifestations of B19 parvovirus other than fifth disease?

A

Aplastic crisis, arthralgia and arthritis, pregnancy complications

34
Q

What virus is responsible for roseola infantum?

A

Human herpes virus 6 (HHV-6)

35
Q

What are the clinical symptoms of roseola infantum?

A

Maculopapular rash following fever, lasts 24-48 hours

36
Q

What is the genome of HHV-6?

A

dsDNA

37
Q

Is HHV-6 enveloped or non-enveloped?

A

Enveloped

38
Q

Where does HHV-6 replicate?

A

T cells, B cells, oral pharynx

39
Q

Where does HHV-6 maintain latency?

A

T cells

40
Q

When does HHV-7 infection occur?

A

Following HHV-6 infection