Flashcards in Viral infections of skin and soft tissue II Deck (40):
1
What type of lesion spread is seen in smallpox?
Centrifugal - mostly on face and extremities
2
What are the features of the smallpox lesion?
Pustular / scabbing, firm to the touch
3
What family does variola virus belong to?
Poxviridae
4
What is the variola virus genome?
Large dsDNA
5
Where does variola virus replicate?
Cytoplasm
6
What virus is responsible for smallpox?
Variola virus
7
What comprises the smallpox vaccine?
Live strain of a vaccinia virus (different poxviridae family member)
8
How can smallpox be differentiated from chickenpox?
Smallpox lesions develop on hands and feet and are synchronous
9
What are the 3 Cs associated with measles?
Cough, coryza, conjunctivitis
10
What sign is pathognomonic for measles?
Koplik's spots - small white spots with red borders opposite molars on oral mucosa
11
How is the measles rash described?
Maculopapular, beginning at the hairline and spready downward
12
What family does the measles virus belong to?
Paramyxoviridae
13
What is the measles virus genome?
ssRNA
14
Is the measles virus enveloped or non-enveloped?
Enveloped
15
Which gene is important for fusion of measles virus?
F gene
16
Which protein is important for attachment of measles virus?
HA protein
17
What percentage of measles cases involve complications?
30%
18
What type of vaccine is the measles vaccine?
Live attenuated
19
When is the measles vaccine recommended?
12-15 months, then at 4-6 years
20
How is the German measles rash described?
Maculopapular, appearing first on face then spreading downward - does not coalesce
21
Which virus is responsible for German measles?
Rubella virus
22
What are the symptoms of congenital rubella syndrome?
Deafness, cataracts, congenital glaucoma, congenital heart disease, pigmentary retinopathy, purpura, hepatosplenomegaly
23
What family does the rubella virus belong to?
Togavirus
24
Is the rubella virus enveloped or non-enveloped?
Enveloped
25
What is the rubella virus genome?
RNA
26
What type of vaccine is the rubella vaccine?
Live attenuated
27
What are the symptoms of fifth disease / erythema infectiosum?
Fever, characteristic rash beginning on cheeks
28
What virus is responsible for fifth disease?
Parvoviridae
29
What is the fifth disease genome?
ssDNA
30
Where does B19 parvovirus grow?
Exclusively in mitotically active cells
31
What virus is responsible for fifth disease?
B19 parvovirus
32
Where does B19 parvovirus live within the body?
Hematopoietic cells in bone marrow
33
What are disease manifestations of B19 parvovirus other than fifth disease?
Aplastic crisis, arthralgia and arthritis, pregnancy complications
34
What virus is responsible for roseola infantum?
Human herpes virus 6 (HHV-6)
35
What are the clinical symptoms of roseola infantum?
Maculopapular rash following fever, lasts 24-48 hours
36
What is the genome of HHV-6?
dsDNA
37
Is HHV-6 enveloped or non-enveloped?
Enveloped
38
Where does HHV-6 replicate?
T cells, B cells, oral pharynx
39
Where does HHV-6 maintain latency?
T cells
40