Viral infections of skin and soft tissue II Flashcards Preview

Year 1 Microbiology > Viral infections of skin and soft tissue II > Flashcards

Flashcards in Viral infections of skin and soft tissue II Deck (40):
1

What type of lesion spread is seen in smallpox?

Centrifugal - mostly on face and extremities

2

What are the features of the smallpox lesion?

Pustular / scabbing, firm to the touch

3

What family does variola virus belong to?

Poxviridae

4

What is the variola virus genome?

Large dsDNA

5

Where does variola virus replicate?

Cytoplasm

6

What virus is responsible for smallpox?

Variola virus

7

What comprises the smallpox vaccine?

Live strain of a vaccinia virus (different poxviridae family member)

8

How can smallpox be differentiated from chickenpox?

Smallpox lesions develop on hands and feet and are synchronous

9

What are the 3 Cs associated with measles?

Cough, coryza, conjunctivitis

10

What sign is pathognomonic for measles?

Koplik's spots - small white spots with red borders opposite molars on oral mucosa

11

How is the measles rash described?

Maculopapular, beginning at the hairline and spready downward

12

What family does the measles virus belong to?

Paramyxoviridae

13

What is the measles virus genome?

ssRNA

14

Is the measles virus enveloped or non-enveloped?

Enveloped

15

Which gene is important for fusion of measles virus?

F gene

16

Which protein is important for attachment of measles virus?

HA protein

17

What percentage of measles cases involve complications?

30%

18

What type of vaccine is the measles vaccine?

Live attenuated

19

When is the measles vaccine recommended?

12-15 months, then at 4-6 years

20

How is the German measles rash described?

Maculopapular, appearing first on face then spreading downward - does not coalesce

21

Which virus is responsible for German measles?

Rubella virus

22

What are the symptoms of congenital rubella syndrome?

Deafness, cataracts, congenital glaucoma, congenital heart disease, pigmentary retinopathy, purpura, hepatosplenomegaly

23

What family does the rubella virus belong to?

Togavirus

24

Is the rubella virus enveloped or non-enveloped?

Enveloped

25

What is the rubella virus genome?

RNA

26

What type of vaccine is the rubella vaccine?

Live attenuated

27

What are the symptoms of fifth disease / erythema infectiosum?

Fever, characteristic rash beginning on cheeks

28

What virus is responsible for fifth disease?

Parvoviridae

29

What is the fifth disease genome?

ssDNA

30

Where does B19 parvovirus grow?

Exclusively in mitotically active cells

31

What virus is responsible for fifth disease?

B19 parvovirus

32

Where does B19 parvovirus live within the body?

Hematopoietic cells in bone marrow

33

What are disease manifestations of B19 parvovirus other than fifth disease?

Aplastic crisis, arthralgia and arthritis, pregnancy complications

34

What virus is responsible for roseola infantum?

Human herpes virus 6 (HHV-6)

35

What are the clinical symptoms of roseola infantum?

Maculopapular rash following fever, lasts 24-48 hours

36

What is the genome of HHV-6?

dsDNA

37

Is HHV-6 enveloped or non-enveloped?

Enveloped

38

Where does HHV-6 replicate?

T cells, B cells, oral pharynx

39

Where does HHV-6 maintain latency?

T cells

40

When does HHV-7 infection occur?

Following HHV-6 infection