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Flashcards in W3-3Nucleotides Deck (13):
1

Gout pathology

Xanthine oxidase overactivity: purine metabolism Treated with XO inhibitor allopurinal Uric acid precipitates in distal parts of body due to decreased body temperature

2

Combined immunodeficiency

Purine nucleoside phosphorylase deficiency

Symptoms: low T-cells, chronic infections, failure to thrive, neurologic symptoms

3

Severe combined immunodefiency

Adenosine deaminase deficiency (elevated 2-deoxyadenosine)

Severe suceptibility to infections

Lymphocytes < 500, costrochondral junction dysplasia

4

Lensch-Nyhan Disease

Hypoxanthine-guanine phosphoribosyltransferase deficiency

X-linked, characterized by self mutalation, neurological symptoms

He's

Got

Purine

Recycling

Trouble

5

These nucleotides are build directly onto the ribose sugar

purines

6

These nucleotides are first built then joined with the sugar

pyrimidines

7

This nucleotide group has several metobolic diseases

purines

8

Sugar used for nucleotide synthesis

phosphoribosyl-1-pyrophosphate

(PRPP)

9

This amino acid donates the first amine group for purine synthesis onto PRPP

glutamine

10

Nucleotides are reduced (for DNA) at which level of phosphorylation

diphosphorylation

11

This enzyme is responsible for reducing the sugar component of nucleotides

ribonucleotide reductase

12

Ribonucleotide reductase uses this cofactor

thioredoxin

13

What is the primary cause of gout?

diet, especially one high in liver and organ meats

exacerbations may occur use to cold