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Flashcards in W3-3Nucleotides Deck (13)
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1
Q

Gout pathology

A

Xanthine oxidase overactivity: purine metabolism Treated with XO inhibitor allopurinal Uric acid precipitates in distal parts of body due to decreased body temperature

2
Q

Combined immunodeficiency

A

Purine nucleoside phosphorylase deficiency

Symptoms: low T-cells, chronic infections, failure to thrive, neurologic symptoms

3
Q

Severe combined immunodefiency

A

Adenosine deaminase deficiency (elevated 2-deoxyadenosine)

Severe suceptibility to infections

Lymphocytes < 500, costrochondral junction dysplasia

4
Q

Lensch-Nyhan Disease

A

Hypoxanthine-guanine phosphoribosyltransferase deficiency

X-linked, characterized by self mutalation, neurological symptoms

He’s

Got

Purine

Recycling

Trouble

5
Q

These nucleotides are build directly onto the ribose sugar

A

purines

6
Q

These nucleotides are first built then joined with the sugar

A

pyrimidines

7
Q

This nucleotide group has several metobolic diseases

A

purines

8
Q

Sugar used for nucleotide synthesis

A

phosphoribosyl-1-pyrophosphate

(PRPP)

9
Q

This amino acid donates the first amine group for purine synthesis onto PRPP

A

glutamine

10
Q

Nucleotides are reduced (for DNA) at which level of phosphorylation

A

diphosphorylation

11
Q

This enzyme is responsible for reducing the sugar component of nucleotides

A

ribonucleotide reductase

12
Q

Ribonucleotide reductase uses this cofactor

A

thioredoxin

13
Q

What is the primary cause of gout?

A

diet, especially one high in liver and organ meats

exacerbations may occur use to cold