Group IV virus type
+ssRNA
Hepatitis C
Group-Family
Group IV-Flaviviridae
T/F HepC has a tegument portion
F
Host response mechanism to Class IV viruses
What if dsRNA is detected inside the cell?
RIG-I recognizes it from surface of mitochondria and initiates idential response as TLR3
NS3/4 A
Protease-ctivates viral proteins
Deactivates TLR3 and RIG-I defense mechanisms
Viral disease mechanisms
1. Cytopathic effect: disrupts physiology
2. Host immune response: causes illness
3. Tumorigenesis: uncontrolled proliferation
(HPV)
Fungi disease mechanisms
1. Overgrowth
2. Host immune response
Protozoa disease mechanisms
1. Displacement
2. Cytopathic: disrupts normal physiology
3. Host immune response
Helminths disease mechanisms
1. Displacement
2. Competition: nutrients with host
3. Host immune response
