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Flashcards in W7 Population Genetics Deck (14)
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1
Q

α-AT (α-1-antitrypsin)

A

ZZoro genotype increases susceptibility to emphysema and lung cancer

2
Q

Heterozygous advantage

A

increases reproductive fitness

3
Q

Allele frequency

A

% of particular allele in gene pool

4
Q

Genotype frequency

A

% of individuals with a certain genotype

5
Q

Hardy-Weinberg Law

A

p2+ 2pq + q2

p + q = 1

6
Q

What needs to be given to determine Hardy-Weinberg equilibrium for autosomal recessive diseases?

A

Disease frequency

incidence = q2

7
Q

Modifier genes

A

can affect onset and severity of a disease: not causative

ex: ApoE4 homozygoes and Alzheimers

8
Q

I-cell disease

A

Mannose-6-P not added to hydrolases, not added to lysosomes

9
Q

Genetic mapping

A

based on phenotypes

following traits in families

10
Q

Linkage analysis

A

2 loci transmitted together more often than anticipated

the closer two loci are–>less likely to be separated during meiosis

11
Q

Recombination factor (RF)

A

lower for loci that are physically closer

12
Q

Association analysis

A

starts with canidate gene

used for complex genetic diseases

13
Q

Calpain-10

A

intronic SNP that plays role in T2D

glucose uptake and insulin secretion

14
Q
A