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Flashcards in W7 Population Genetics Deck (14):
1

α-AT (α-1-antitrypsin)

ZZoro genotype increases susceptibility to emphysema and lung cancer

2

Heterozygous advantage

increases reproductive fitness

3

Allele frequency

% of particular allele in gene pool

4

Genotype frequency

% of individuals with a certain genotype

5

Hardy-Weinberg Law

p+ 2pq + q2

 

p + q = 1

6

What needs to be given to determine Hardy-Weinberg equilibrium for autosomal recessive diseases?

Disease frequency

 

incidence = q2

7

Modifier genes

can affect onset and severity of a disease: not causative

 

ex: ApoE4 homozygoes and Alzheimers

8

I-cell disease

Mannose-6-P not added to hydrolases, not added to lysosomes

9

Genetic mapping

based on phenotypes

 

following traits in families

10

Linkage analysis

2 loci transmitted together more often than anticipated

 

the closer two loci are-->less likely to be separated during meiosis

11

Recombination factor (RF)

lower for loci that are physically closer

12

Association analysis

starts with canidate gene

 

used for complex genetic diseases

13

Calpain-10

intronic SNP that plays role in T2D

glucose uptake and insulin secretion

14