Western-Immune System Flashcards Preview

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Flashcards in Western-Immune System Deck (25):
1

Hypersensitivity Reaction-Type 1

IgE antibody reaction occurs w/in 15-30 minutes of exposure & sometimes 10-12 hrs after exposure. Anaphylaxis is the most severe type.

Ex. allergic rhinitis, allergic conjunctivitis, allergic asthma & food allergies.

2

Hypersensitivity Reaction-Type 2

Symptoms emerge w/in few minutes to several hrs after the antibody-antigen binding.

Ex. hemolytic anemia, blood transfusions, many drug allergies (penicillan for one).

3

Hypersensitivity Reaction-Type 3

Reaction is usually 3 to 10 hrs after the immune complex forms.

Ex. SLE, glomerulonephritis, polyarteritis, vasculitis, RA

4

Hypersensitivity Reaction-Type 4

T-cell lymphocytes (mostly T-cells) are also called delayed-type hypersensitivity (DTH) reactions which usually take days or weeks to manifest.

Ex. rashes like poison ivy, poison oak, bacteria or fungi that the body can't completely eliminate

5

Immunoglobin-IgM

Synthesized by immature Beta cells, produced after initial contact w/ antigen; does NOT cross the placenta.

6

Immunoglobin-IgG

Most abundant-makes up 75% of antibodies in blood; DOES cross the placenta.

7

Immunoglobin-IgA

Present in mucus membranes, saliva, tears, colostrums (mother's first milk); does NOT cross the placenta.

8

Immunoglobin-IgE

Associated w/ allergies.

9

Immunoglobin-IgD

Unknown

10

Components of Blood-Platelets

Important in coagulation.

11

Components of Blood-Erythrocytes

Transport of respiratory gases-depend on hemogoblin.

12

Components of Blood-Leukocytes

(WBC) Most important cellular components in the body's defenses.

13

Components of Blood-Neutrophils

Cellular defense phagocytosis of small pathogenic microorganisms, bacterial infections, inflammation & stress responses.

14

Components of Blood-Eosinophils

Lining of respiratory & digestive tract, parasites & allergins.

15

Components of Blood-Basophils

Contains histamine (anti-inflammatory) and heparin (anticoagulant)

16

Components of Blood-Lymphocytes

Smallest, T's directly attack infected or cancerous cells, viral infections.

17

Components of Blood-Monocytes

Largest, phagocytosis of large bacterial organisms, chronic viral infections

18

Components of Blood-Macrophages

Large eaters. These are large & long lived. They capture foreign cells, digest & present protein fragments (peptides) from the cells. They present the antigen to T-cells.

19

Immune System-First Line of defense

Skin & mucus membranes

20

Immune System-Second Line of defense

Inflammation

21

Immune System-Third (and last) Line of defense

Immune response

22

Immune System-Lymphocytes

Primary cell for immune response; originates in LV, SP and bone marrow of the fetus.

23

Immune System-T-Lymphocytes

Migrate through the thymus gland to become T-Lymphocytes (cell-mediated immunity). Cells leave the marrow at an early age & travel to the thymus & mature. Recognizes "self & non-self" substances.

24

Immune System-B-Lymphocytes

Mature in bone marrow.

25

Immune System-Lymph Nodes

Filter lymph & phagocytes (eat foreign particles) from harmful bacteria & microorganisms.

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