Flashcards in Western-Immune System Deck (25):
Hypersensitivity Reaction-Type 1
IgE antibody reaction occurs w/in 15-30 minutes of exposure & sometimes 10-12 hrs after exposure. Anaphylaxis is the most severe type.
Ex. allergic rhinitis, allergic conjunctivitis, allergic asthma & food allergies.
Hypersensitivity Reaction-Type 2
Symptoms emerge w/in few minutes to several hrs after the antibody-antigen binding.
Ex. hemolytic anemia, blood transfusions, many drug allergies (penicillan for one).
Hypersensitivity Reaction-Type 3
Reaction is usually 3 to 10 hrs after the immune complex forms.
Ex. SLE, glomerulonephritis, polyarteritis, vasculitis, RA
Hypersensitivity Reaction-Type 4
T-cell lymphocytes (mostly T-cells) are also called delayed-type hypersensitivity (DTH) reactions which usually take days or weeks to manifest.
Ex. rashes like poison ivy, poison oak, bacteria or fungi that the body can't completely eliminate
Synthesized by immature Beta cells, produced after initial contact w/ antigen; does NOT cross the placenta.
Most abundant-makes up 75% of antibodies in blood; DOES cross the placenta.
Present in mucus membranes, saliva, tears, colostrums (mother's first milk); does NOT cross the placenta.
Associated w/ allergies.
Components of Blood-Platelets
Important in coagulation.
Components of Blood-Erythrocytes
Transport of respiratory gases-depend on hemogoblin.
Components of Blood-Leukocytes
(WBC) Most important cellular components in the body's defenses.
Components of Blood-Neutrophils
Cellular defense phagocytosis of small pathogenic microorganisms, bacterial infections, inflammation & stress responses.
Components of Blood-Eosinophils
Lining of respiratory & digestive tract, parasites & allergins.
Components of Blood-Basophils
Contains histamine (anti-inflammatory) and heparin (anticoagulant)
Components of Blood-Lymphocytes
Smallest, T's directly attack infected or cancerous cells, viral infections.
Components of Blood-Monocytes
Largest, phagocytosis of large bacterial organisms, chronic viral infections
Components of Blood-Macrophages
Large eaters. These are large & long lived. They capture foreign cells, digest & present protein fragments (peptides) from the cells. They present the antigen to T-cells.
Immune System-First Line of defense
Skin & mucus membranes
Immune System-Second Line of defense
Immune System-Third (and last) Line of defense
Primary cell for immune response; originates in LV, SP and bone marrow of the fetus.
Migrate through the thymus gland to become T-Lymphocytes (cell-mediated immunity). Cells leave the marrow at an early age & travel to the thymus & mature. Recognizes "self & non-self" substances.
Mature in bone marrow.