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Flashcards in 00 Drugs in Pregnancy Deck (32):
1

What is preeclampsia?

Condition during pregnancy characterized by worsening hypertension and proteinuria

2

What is eclampsia?

An acute and life-threatening complication of pregnancy characterized by seizures

3

What are some examples of Pregnancy Category A drugs?

Levothyroxine, Folic Acid, Riboflavin

4

What is Lithium use like in pregnancy?

Avoid if possible during first trimester, causes Ebstein's anomaly (valve abnormally formed in heart). Pregnancy category D

5

What can Carbamazepine and Valproic Acid cause?

Spina bifida

6

What medication has been suspected as a risk factor for Autism Spectrum Disorder (ASD)?

VPA

7

What are some "X-Rated" Drugs?

Isotretinoin, Statins, Live vaccines, MTX, Finasteride, Medroxyprogesterone, Ribavirin, Temazepam, Triazolam, Quinine, Misoprostol, Mifepristone

8

Which medication is in the iPLEDGE program?

Isotretinoin

9

Which medication is in the STEPS program?

Thalidomide. STEPS: System for Thalidomide Education and Prescribing Safety

10

What is the generic name for Arava?

Leflunomide (for RA)

11

What needs to be done upon d/c of Arava (Leflunomide)?

It is recommended that all women of childbearing potential undergo drug elimination procedure (Cholestyramine 8g PO TID for up to 11 days)

12

What is the generic of Mifeprex?

Mifepristone (RU-486). Used with Misoprostol (Cytotec). Used for termination of pregnancy up to 49 days

13

What are some common medications that should not even be handled by pregnant people?

5-alpha reducatse inhibitors (Proscar, Propecia, Avodart). Testosterone (Androgel, Androderm). MTX, Ribavirin, Ganciclovir

14

What are some drugs that can be used during pregnancy to help with high BP?

Mainly: Labetalol, Methyldopa, Nifedipine. Metoprolol and Pindolol are reported safe

15

Which BP medications are contraindicated during pregnancy?

ACE-I, ARB, Direct Renin Inhibitor (e.g., Aliskiren, Tekturna)

16

What is the DOC for analgesia in pregnancy?

APAP. Avoid ASA, all NSAIDs in 3rd trimester

17

What are the safe anti-infective agents in pregnancy?

Amoxicillin, PCN, Cephalosporins, Clindamycin, Erythromycin, Azithromycin, Dicloxacillin

18

What are the safe CNS drugs in pregnancy?

Haloperidol, Atypical APs, Zolpidem, Zaleplon, Methadone

19

What CNS drugs need to be avoided in pregnancy?

Ergots, CBZ, VPA, BZD hypnotics (not all BZDs), MAOI's, Paxil

20

What are the safe Pulmonary drugs in pregnancy?

Inhaled corticosteroids, theophylline, montelukast

21

What is the DOC for diabetes in pregnancy?

Insulin. AVOID sulfonylureas

22

What are the safe drugs for cough/cold in pregnancy?

Dextromethorphan, Guaifenesin, Loratadine, Chlorpheniramine, Diphenhydramine

23

What are the safe drugs for GI issues in pregnancy?

H1&2 antagonists (eg. Doxylamine), Antacids, Ginger, Docusate, ~simethicone

24

What GI drugs need to be avoided in pregnancy?

Metoclopramide, Prochlorperazine, Promethazine, Kaopectate (bismuth subsalicylate)

25

What laxatives are ok to recommend in pregnancy?

DOC: Psyllium, DOSS. Recommend: increase fluid and fiber intake. AVOID: Mineral oil and Caster oil

26

What is the preferred PPI in pregnancy?

Lansoprazole

27

What are the preferred H2 antagnoists/blockers in pregnancy?

Cimetidine and ranitidine

28

What topical drugs for acne are considered safe in pregnancy?

Benzoyl peroxide, Clindamycin, Erythromycin

29

What is Diclegis?

Combination drug for morning sickness (Doxylamine and Pyridoxine (vitamin B6)). Pregnancy Category A

30

What medications are ok to use for morning sickness?

Diclegis, Premesis RX (ginger, doxylamine, pyridoxine), Emetrol, Ginger

31

How often should TSH be checked during pregnancy?

Every 4 weeks for first 20 weeks gestation. Check TSH once between 26-32 weeks gestation at least. Check TSH at 6 weeks postpartum

32

Which drugs should generally be avoided during lactation?

DA agonists (eg, Bromocriptine, Levodopa), Ergot derivatives, CSA, MTX (immunosuppression), Lithium, Chloramphenicol, Quinolones, "Street" drugs