Flashcards in 00 Chemotherapy Deck (93)
What is the generic name of Cytoxan?
Cyclophosphamide (Alkylating agent)
What are the ADRs associated with Cytoxan (Cyclophosphamide)?
DLT: Myelosuppression. High dose: cardiotoxicity, hemorrhagic cystitis
What is a common class side effect/warning with alkylating agents?
What is the generic name of Ifex?
Ifosfamide (Alkylating agent)
What can be used to prevent hemorrhagic cystitis (with ifosfamide and cyclophosphamide)?
Hyper-hydration with NS to flush out ACROLEIN. The use of Mesna (Mesnex), continue a few hours after end of chemo
What is the generic name of Busulfex?
Busulfan (Alkylating agent)
What is a unique side effect of Busulfan?
"Busulfan tan", "Busulfan lung", seizures
What should be used with high dose Busulfan?
Antiepileptic prophylaxis (commonly with Keppra)
What is the generic name of Trexall, Rheumatrax?
What are some common side effects with Methotrexate?
Myelosuppression, hepatotoxic, nephrotoxic
What are the contraindications to MTX use?
Severe renal/hepatic dysfunction. Pregnancy (Category X)
What are some more common DDIs with MTX to keep an eye out for?
NSAID/Probenecid (increases [MTX] by competing for renal clearance)
What is one way to increase the excretion of MTX?
Urine alkalinization with NaHCO3 can increase renal clearance (especially w/ high dose)
What can be used for MTX-induced myelosuppression?
Leucovorin, start 24 hours after MTX administration
What is the generic name of Voraxaze?
Glucarpidase (used for MTX toxicity)
What is the generic name of Alimta?
What needs to be done before starting Alimta (Premetrexed)?
Daily folic acid and Q9 weeks of Vitamin B12 starting 1 week prior to reduce heme/GI toxicities
What is the generic name of Adrucil?
What are the side effects associated with 5-FU?
Myelosuppression (Bolus > IV), Hand-foot syndrome (IV > bolus), Diarrhea/mucositis (IV > Bolus)
What is the generic name of Xeloda?
Capecitabine (oral pro-drug of 5-FU)
How do the side effects of Xeloda compare to 5-FU?
Similar, except more GI SEs (diarrhea, N/V, mucositis)
What is the generic name of Kepivance?
Palifermin (IV drug to help manage Mucositis)
What is the generic name of Gemzar?
What is the generic name of Ara-C?
What are some toxicities with Ara-C (Cytarabine) to look out for?
High dose: Cerebullar toxicity (trouble walking straight, sitting up, writing), Conjuntivitis, N/V/mucositis
How is Purinethol (Mercaptopurine) metabolized?
By Xanthine oxidase (w/ allopurinol decrease dose by 50-75%)
What are the boxed warnings for Taxanes?
Myelosuppression, Hypersensitivity (w/i 2-3 mins, pre-med w/ steroids, H1RA, H2RA)
What is the generic name of Taxol?
Paclitaxel (Taxane) - contains Cremophor in formulation, this causes the hypersensitivity reactions
What is the generic name of Abraxane?
Paclitaxel Albumin-bound (Taxane) - no need for premeds, doesn't contain Cremophor