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Flashcards in 00 Male Issues Deck (39):
1

What is the normal range for Prostate Specific Antigen (PSA)?

0-4 ng/mL

2

What are some medications that may worsen BPH?

Anticholinergics (TCAs, antipsychotics, etc), Antihistamines, Decongestants, Diuretics, Caffeine

3

What is the generic name of Hytrin?

Terazosin - BPH (Non-selective Alpha-1 blocker)

4

What is the generic name of Cardura?

Doxazosin - BPH (Non-selective Alpha-1 blocker)

5

What is the generic name of Uroxatral?

Alfuzosin - BPH (Non-selective Alpha-1 blocker)

6

What is the generic name of Flomax, Jalyn?

Tamsulosin - BPH (Selective Alpha-1a blocker)

7

What is the generic name of Rapaflo?

Silodosin - BPH (Selective Alpha-1a blocker)

8

What is important to know about Alpha-1 blockers in BPH?

1st dose phenomenon (orthostatic hypotension), dose at night. Does NOT affect PSA levels nor shrink the prostate. Can cause Priapism

9

What is important to know about 5-alpha reductase inhibitors in BPH?

Associated with prostate SHRINKAGE and symptom improvement. Delayed onset of response vs alpha blockers

10

What is the generic name of Proscar?

Finasteride - BPH (5-alpha reductase inhibitor)

11

What is the generic name of Avodart, Jalyn?

Dutasteride - BPH (5-alpha reductase inhibitor)

12

What pregnancy category are the 5-alpha reductase inhibitors used for BPH?

Category X

13

What are the main ADRs for 5-alpha reductase inhibitors for BPH?

Sexual dysfunction, Breast swelling and tenderness

14

What is the generic name of Viagra?

Sildenafil (PDE-5 inhibitor)

15

What is the generic name of Cialis?

Tadalafil (PDE-5 inhibitor)

16

What is the generic name of Levitra?

Verdenafil (PDE-5 inhibitor)

17

What is the generic name of Stendra?

Avanafil (PDE-5 inhibitor)

18

When are PDE-5 inhibitors contraindicated?

With Nitrates!

19

What are some unusual ADRs with PDE-5 inhibitors?

Transient abnormal blue/green vision (mostly with Sildenafil). Sudden vision loss d/t nonarteritic ischemic optic neuropathy (NAION). Priapism

20

What is the generic name of Rogaine?

Minoxidil (used for baldness) - increases blood flow to hair

21

What is the generic name of Propecia?

Finasteride (used for baldness) - inhibits testosterone --> DHT

22

Which baldness medication can be used in both men and women?

Rogaine (Minoxidil)

23

What are some medications that can induce hypogonadism?

Ketoconazole, Glucocorticoids, Spironolactone, Cimetidine, Phenytoin, Opioids, Alcohol, Anabolic steroids, Flutamide

24

What type of allergy should Androgel, Striant, Testim be avoided in?

Soy

25

What are the two oral medications that can be used for hypogonadism?

Methyltestosterone or Fluoxymesterone

26

What are the oral preparations limitations for hypogonadism?

Poor oral bioavailability, Poor androgen effect, Adverse lipid changes, Priapism, Increased risk of hepatic side effects

27

What is the generic name of Striant?

Testosterone buccal preparation - used for hypogonadism

28

What are the advantages of testosterone buccal preparation (Striant)?

BID dosing allows for normal testosterone levels throughout the day

29

What is the generic name of Androderm?

Testosterone transdermal patch (for hypogonadism). Should be applied in the evening, if it falls off you may press back on or replace before noon

30

Where can Androderm patch be placed?

Upper arms or back. Abdomen. Thighs

31

What are the advantages of using Androderm?

Closely mimics normal diurnal changes in testosterone levels

32

What is the generic name of AndroGel?

Testosterone gel formulation

33

What is the generic name of Testim?

Testosterone gel formulation

34

Where can AndroGel be applied?

Upper arms or Abdomen

35

Where can Testim be applied?

Upper arms only

36

What is the generic name of Fortesta?

Testosterone gel formulation

37

Where can Fortesta be applied?

To the thighs only!

38

What is the generic name of Axiron?

Testosterone topical formulation used in armpit, apply deodorant first

39

What should a patient do to minimize first-dose syncope with terazosin?

Start with 1mg daily