Flashcards in 00 Epilepsy Study Questions Deck (77):
Generic name of: Luminal
Generic name of: Dilantin
Generic name of: Valium
Generic name of: Diastat
Diazepam (Rectal Gel)
Generic name of: Klonopin
Generic name of: Tegretol
Generic name of: Epitol
Generic name of: Carbatrol
Generic name of: Depakene
Generic name of: Depakote
Generic name of: Depacon
Generic name of: Neurontin
Generic name of: Lamictal
Generic name of: Topamax
Generic name of: Trileptal
Generic name of: Oxtellar XR
Generic name of: Keppra
Generic name of: Lyrica
What happens when Lamictal (Lamotrigine) is added to an AED regimen containing Valproate?
Dosing changes whether you are using an inducer or inhibitor
Petit Mal is known as what kind of seizure?
Grand Mal is known as what kind of seizure?
What is the DOC for absence seizure?
Ethosuximide (Zarontin) or Depakote is a good choice if that can't be used
What is the therapeutic range for Carbamazepine?
What is the therapeutic range for Ethosuximide
What is the therapeutic range for Phenobarbital?
What is the therapeutic range for Primidone?
What is the therapeutic range for Phenytoin?
What is the therapeutic range for Valproic Acid?
What test is used to measure seizure activity?
After initial dosing has been initiated, which anticonvulsant requires higher doses to achieve the same effects after several days?
Carbamazepine d/t auto-induction
Which anticonvulsant should you avoid in sulfa allergy?
Which anticonvulsant should you avoid in patients with a previous hypersensitivity reaction to carbamazepine?
Which voltage-dependent channels are inhibited by some AEDs?
Na+ and Ca2+
What does GABA stand for?
Gamma Amino Butyric Acid
What are some common drugs that decrease seizure threshold?
Caffeine, Anti-depressants (e.g., Bupropion), Tramadol (>400mg), Meperidine (use morphine instead), Anti-psychotics (Clozapine, Chorpromazine), Theophylline
What is the broad spectrum AED that can be used in almost all patients?
What is Status Epilepticus?
Continuous grand mal seizures lasting at least 5 (up to 30) minutes, or two or more sequential seizures without full recovery of consciousness between seizure attacks. Medical emergency. CAN'T USE ORAL MEDICATIONS
What are the DOC's for Status Epilepticus?
Diazepam (Valium, Diastat rectal gel) OR Lorazepam. Valproate sodium (Depacon) can always be used an an alternate
What are the DOC's for Partial Seizures?
Carbamazepine. Valproate as an alternative
What are the DOC's for Tonic-Clonic Seizures?
Valproate OR Carbamazepine
Which AEDs can cause Hyponatremia?
Which AEDs can cause Hyperammonemia?
Which AEDs can cause Pancreatitis?
Which AEDs can cause Polycystic Ovaries?
Valproic Acid, Carbamazepine
Which AEDs can cause Fatal Aplastic Anemia?
Which AEDs can cause Kidney Stones?
Which AEDs can cause Gingival Hyperplasia?
Which AEDs can cause SJS?
Which AEDs can cause Hiccups?
Which AEDs can cause Purple Glove Syndrome?
Which AEDs can cause QTc Prolongation?
Which AEDs can cause Urinary Retention?
What are the C-IV AEDs?
All benzos, Phenobarbital, Mephobarbital
What are the C-V AEDs?
Pregabalin, Lacosamide, Ezogabine
What are the AEDs that can have loading doses?
Fosphenytoin, Phenobarbital, Valproate Sodium
What are the AEDs that are big enzyme inducers?
Carbamazepine, Oxcarbazepine, Phenytoin, Fosphenytoin, Phenobarbital, Primidone, Topiramate (> 200mg)
When would be a time when Valproic acid would not be an appropriate choice?
How does Oxcarbazepine compare to Carbamazepine?
Oxcarbazepine is advantages over CBZ in every way except that it causes hyponatremia
Why does Carbamazepine have so many SEs?
Because it is metabolized into 10,11-epoxide
How does Phenytoin compare to Fosphenytoin?
Phenytoin: infuse at 50mg/min in saline only. Fosphenytoin: infuse at 150mg/min in saline or dextrose
What pregnancy category do most AEDs fall into?
What are the Pregnancy Category D AEDs?
BZDs, Phenobarbital/primidone, VPA, Carbamazepine, Phenytoin/Fosphenytoin, Topiramate
What patients need to be screened before CBZ?
Asian descent for the HLA-B*1502 gene
When should you dose adjust Phenobarbital?
Decrease dose in renal or hepatic dysfunction
What seizure type must Phenytoin be avoided in?
When is Phenytoin contraindicated?
Heart issues (2nd or 3rd degree AV block, sinus bradycardia, sino-atrial block)
What is the generic of Onfi?
What genetic polymorphism should be identified for Clobazam users?
CYP 2C19, polymorphism causes higher levels of drug, need to lower dose
What is the BBW for Valproate?
Hepatotoxicity, Teratogenicity, Pancreatitis
What is Stavzor?
Delayed-release capsules of Valproate
What is the BBW for Lamotrigine?
Life-threatening rashes. Slow gradual titration of dose may reduce the incidence
What do you need to advise patients who are going to start Topiramate?
Increase fluid intake to decrease risk of kidney stones
What is the generic for Oxtellar XR?
Oxcarbazepine extended release tabs
What are the drug interactions like with Keppra?
None clinically important, not metabolized by CYP450
What is the generic of Sabril?
What is Vigabatrin indicated for?
Refractory Epilepsy Infantile Spasms (IS)