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1

What is the preferred combination therapy for Treatment Naive patients?

1 NNRTI or PI or INSTI (+ 2 NRTIs)

2

For the initial treatment of Treatment Naive patients using: 1 NNRTI or PI or INSTI (+ 2 NRTIs), what is the preferred "1 NNRTI"?

Efavirenz

3

For the initial treatment of Treatment Naive patients using: 1 NNRTI or PI or INSTI (+ 2 NRTIs), what is the preferred "PI"?

Atazanavir/Ritonavir combo

4

For the initial treatment of Treatment Naive patients using: 1 NNRTI or PI or INSTI (+ 2 NRTIs), what is the preferred "INSTI"?

Raltegravir

5

For the initial treatment of Treatment Naive patients using: 1 NNRTI or PI or INSTI (+ 2 NRTIs), what are the "2 NRTIs"?

Tenofavir + Emtricitabine

6

What does NRTI stand for?

Nucleoside/tide Reverse Transcriptase Inhibitors

7

What is the generic name of Ziagen?

Abacavir (NRTI)

8

What is the generic name of Epzicom?

Abacavir + Lamivudine

9

What is the BBW for all NRTIs?

Lactic acidosis and severe hepatomegaly with steatosis, sometimes fatal, especially with stavudine, didanosine and zidovudine

10

What must you screen for before starting Ziagen (Abacavir)?

Must screen for the HLA-B*5701 allele prior to starting abacavir therapy - if positive, increased risk for hypersensitivity reaction so do not use. Record as abacavir allergy in patient record

11

What is the generic name of Emtriva?

Emtricitabine (NRTI)

12

What is the generic name of Truvada?

Emtricitabine (NRTI) + Tenofovir (NtRTI)

13

What is the generic name of Atripla?

Emtricitabine (NRTI) + Tenofovir (NtRTI) + Efavirenz (NNRTI)

14

What is the generic name of Epivir?

Lamivudine (NRTI)

15

What is the generic name of Epzicom?

Lamivudine (NRTI) + Abacavir (NRTI)

16

What does 3TC stand for?

Lamivudine

17

What does FTC stand for?

Emtricitabine

18

What does ABC stand for?

Abacavir

19

What BBW is there for Lamivudine, Emtricitabine, and Tenofovir?

May exacerbate Hepatitis B once drug is discontinued or HBV resistance may develop

20

What is the generic name of Viread?

Tenofovir (NRTI)

21

What does TDF stand for?

Tenofovir

22

What is the only NRTI that CANNOT be taken w/ food?

Videx (Didanosine)

23

What is a class effect with NNRTIs?

Hepatotoxicity! Rash (SJS/TEN)

24

What is the generic name of Sustiva?

Efavirenz

25

What does EFV stand for?

Efavirenz

26

What are some side effects to look out for with Efavirenz?

CNS (impaired concentration, drowsiness, vivid dreams - usually resolve w/in 2-4 weeks) and psychiatric symptoms (depression, paranoia, suicide)

27

What are the common side effects seen for all Protease Inhibitors (PIs)?

Hyperglycemia/insulin resistance/diabetes, lipoatrophy, fat maldistribution, hyperlipidemia, hepatitis and hepatic decompensation, immune reconstitution syndrome

28

What is the generic name of Reyataz?

Atazanavir (PI)

29

What does ATV stand for?

Atazanavir (PI)

30

How is Atazanavir usually dosed?

300mg + 100mg Ritonavir daily