Flashcards in 00 Arthritis Deck (26)
What is the DOC for osteoarthritis?
What are some Diclofenac Topicals?
Flector patch, Voltaren Gel. Pennsaid. Low systemic absorption minimizes NSAID ADRs
What is the generic name of Trexall?
Methotrexate (Non-Biologic DMARD) - RA
What does DMARD stand for?
Disease-Modifying Antirheumatic Drugs
What is the generic name of Arava?
Leflunomide (Non-Biologic DMARD) - RA
What is the generic name of Plaquenil?
Hydroxychloroquine (Non-Biologic DMARD) - RA
What is the generic name of Azulfidine?
Sulfasalazine (Non-Biologic DMARD) - RA
What is the generic name of Minocin?
Minocycline (Non-Biologic DMARD) - RA (not FDA-approved)
What is considered the DOC for RA?
How often is Methotrexate dosed?
What supplementation do you need while on Methotrexate therapy?
What are the contraindications for Methotrexate use?
Liver disease/EtOH. Immunodeficiency. Pleural or peritoneal effusions. Leukopenia. Thrombocytopenia. Pre-existing blood disorders. CrCl < 40. Pregnancy and Lactation
What is Arava (Leflunomide) indicated for?
RA/JRA only. As effective as MTX, but $$$$
How is Arava (Leflunomide) dosed?
3 day loading dose, then DAILY maintenance
What are the contraindications for Azulfidine (Sulfasalazine)?
Sulfa allergy. Salicylate allergy. GI obstruction
What are some classes of medications that fall under the Biologic DMARDs?
TNF-a Inhibitors, T Cell Inhibitor, B Cell Modifier, IL-6 Inhibitor, Janus Kinase Inhibitor
What is the generic name of Enbrel?
Etanercept (TNF-a inhibitor) - RA, can be used alone or with MTX
What is the generic name of Humira?
Adalimumab (TNF-a inhibitor) - RA, can be used alone or with other DMARDs
What is the generic name of Remicade?
Infliximab (TNF-a inhibitor) - RA, can be used alone or with MTX
What are the BBWs for TNF-a inhibitors?
Contraindicated with any infection, Tuberculosis
What is the generic name of Rituxan?
Rituximab (B-cell modifier) - RA, LAST LINE
What are the BBWs for Rituxan (Rituximab)?
Fatal infusion reactions. Tumor lysis syndrome. Severe mucocutaneous reactions. Progressive multifocal leukoencephalopathy
What type of screening is recommended in all patients being considered for biologic DMARD therapy?
Which DMARD is also an antimalarial drug?
What are the potential ADRs with MTX?
Bone marrow suppression, GI upset, pulmonary fibrosis