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Flashcards in 00 Arthritis Deck (26):
1

What is the DOC for osteoarthritis?

APAP

2

What are some Diclofenac Topicals?

Flector patch, Voltaren Gel. Pennsaid. Low systemic absorption minimizes NSAID ADRs

3

What is the generic name of Trexall?

Methotrexate (Non-Biologic DMARD) - RA

4

What does DMARD stand for?

Disease-Modifying Antirheumatic Drugs

5

What is the generic name of Arava?

Leflunomide (Non-Biologic DMARD) - RA

6

What is the generic name of Plaquenil?

Hydroxychloroquine (Non-Biologic DMARD) - RA

7

What is the generic name of Azulfidine?

Sulfasalazine (Non-Biologic DMARD) - RA

8

What is the generic name of Minocin?

Minocycline (Non-Biologic DMARD) - RA (not FDA-approved)

9

What is considered the DOC for RA?

Trexall (Methotrexate)

10

How often is Methotrexate dosed?

WEEKLY!!!

11

What supplementation do you need while on Methotrexate therapy?

Folic acid

12

What are the contraindications for Methotrexate use?

Liver disease/EtOH. Immunodeficiency. Pleural or peritoneal effusions. Leukopenia. Thrombocytopenia. Pre-existing blood disorders. CrCl < 40. Pregnancy and Lactation

13

What is Arava (Leflunomide) indicated for?

RA/JRA only. As effective as MTX, but $$$$

14

How is Arava (Leflunomide) dosed?

3 day loading dose, then DAILY maintenance

15

What are the contraindications for Azulfidine (Sulfasalazine)?

Sulfa allergy. Salicylate allergy. GI obstruction

16

What are some classes of medications that fall under the Biologic DMARDs?

TNF-a Inhibitors, T Cell Inhibitor, B Cell Modifier, IL-6 Inhibitor, Janus Kinase Inhibitor

17

What is the generic name of Enbrel?

Etanercept (TNF-a inhibitor) - RA, can be used alone or with MTX

18

What is the generic name of Humira?

Adalimumab (TNF-a inhibitor) - RA, can be used alone or with other DMARDs

19

What is the generic name of Remicade?

Infliximab (TNF-a inhibitor) - RA, can be used alone or with MTX

20

What are the BBWs for TNF-a inhibitors?

Contraindicated with any infection, Tuberculosis

21

What is the generic name of Rituxan?

Rituximab (B-cell modifier) - RA, LAST LINE

22

What are the BBWs for Rituxan (Rituximab)?

Fatal infusion reactions. Tumor lysis syndrome. Severe mucocutaneous reactions. Progressive multifocal leukoencephalopathy

23

What type of screening is recommended in all patients being considered for biologic DMARD therapy?

TB screening

24

Which DMARD is also an antimalarial drug?

Hydroxychloroquine

25

What are the potential ADRs with MTX?

Bone marrow suppression, GI upset, pulmonary fibrosis

26

What is a potentially serious side effect of Hydroxychloroquine?

Retinal toxicity