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AA Microbio Semifinal > II-A. Systemic bacteriology | 18. Yersinia and Pasteurella genus > Flashcards

II-A. Systemic bacteriology | 18. Yersinia and Pasteurella genus Flashcards

1
Q

I. Pasteurella genus
1. What are the features of Pasteurella genus?

A

Gram-negative, facultative anaerobic rods

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2
Q

I. Pasteurella genus
2. What is the important species of Pasteurella genus

A

Pasteurella multocida

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3
Q

I. Pasteurella genus
3. what is the source of infection for Pasteurella genus?

A

animals (zoonosis)

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4
Q

I. Pasteurella genus
4. what is the route of transmission for Pasteurella genus?

A

route of transmission: usually through animal bite (cat, dog)
- animal salive could be infectious as well, even without bite!

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5
Q

I. Pasteurella genus
5. what are the diseases caused by Pasteurella genus?

A
  • soft tissue infections (wound infections)
  • rarely systemic infections (endocarditis, meningitis, blood stream infection)
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6
Q

I. Pasteurella genus
6. how should we diagnose Pasteurella genus?

A
  • clinical signs and symptoms
  • sampling: wound swab / aspirate, blood culture, CSF in systemic infectinos
  • laboratory: culturing
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7
Q

I. Pasteurella genus
7. What is the empirical therapy for Pasteurella genus?

A
  • pathogens are usually sensitive to beta-lactam – beta-lactamase inhibitor combinations, cephalosporins, carbapenems
  • pathogens are usually sensitive to lincosamides (clindamycin), fluoroquinolons (levofloxacin) as well
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8
Q

II. Yersinia genus
1. What are the important species of Yersinia genus?

A
  • Y. pestis
  • Y. enterocolitica
  • Y. pseudotuberculosis
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9
Q

II. Yersinia genus - Yersinia pestis
2. What is Yersinia pestis?

A

pathogen of (black) plague

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10
Q

II. Yersinia genus - Yersinia pestis
3. What is the source of infection of Yersinia pestis?

A

rodents (zoonotic disease!)

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11
Q

II. Yersinia genus - Yersinia pestis
4. What is the route of transmission of Yersinia pestis?

A

by the bite of rat flea (generally)

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12
Q

II. Yersinia genus - Yersinia pestis
5. Where can you find Yersinia pestis?

A

endemic regions in the Americas, in Asia

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13
Q

II. Yersinia genus - Yersinia pestis
6. What are the disease forms of Yersinia pestis?

A
  • bubonic plague (fever, headache, lymphadenopathy)
  • septicaemic plague (fatigue, necrotic lesions)
  • pulmonary plague (haemorrhagic necrotising pneumonia, sputum!)
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14
Q

II. Yersinia genus - Yersinia pestis
7. What is the pathomechanism of Yersinia pestis?

A

as the bacterium reaches the lung becomes capable of to spread from human to human via respiratory droplets
* primary pulmonary plague in the infected ➡ epidemic starts

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15
Q

II. Yersinia genus - Yersinia pestis
8. What is the diagnosis of Yersinia pestis?

A
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16
Q

II. Yersinia genus - Yersinia pestis
9. What is the empirical therapy of Yersinia pestis?

A

aminoglycosides or tetracyclines immediately

17
Q

II. Yersinia genus - Yersinia pestis
10. What is the prevention of Yersinia pestis?

A
  • rodent (and flea) control
  • active immunisation (vaccine) in high risk areas
  • isolation of the infected person!
18
Q

II. Yersinia genus - Yersinia enterocolitica
11. What’re the features of of Yersinia enterocolitica?

A

able proliferate at 4 C!
* may infect blood products (spread via transfusion!)

19
Q

II. Yersinia genus - Yersinia enterocolitica
13. What is the route of transmission of Yersinia enterocolitica?

A

through consumption contaminated food

21
Q

II. Yersinia genus - Yersinia enterocolitica
14. what are the diseases caused by Yersinia enterocolitica?

A
  • gastroenteritis (diarrhoea), enterocolitis
  • symptoms could mimic appendicitis symptoms!
  • blood stream infection, sepsis (rarely)
  • sequelae (arthritis, erythema nodosum)
21
Q

II. Yersinia genus - Yersinia enterocolitica
12. What is the source of infection of Yersinia enterocolitica?

A

swine, products of other animals (zoonosis)

21
Q

II. Yersinia genus - Yersinia enterocolitica
12. What is the source of infection of Yersinia enterocolitica?

A

swine, products of other animals (zoonosis)

21
Q

II. Yersinia genus - Yersinia enterocolitica
12. What is the source of infection of Yersinia enterocolitica?

A

swine, products of other animals (zoonosis)

22
Q

II. Yersinia genus - Yersinia enterocolitica
12. What is the source of infection of Yersinia enterocolitica?

A

swine, products of other animals (zoonosis)

22
Q

II. Yersinia genus - Yersinia enterocolitica
12. What is the source of infection of Yersinia enterocolitica?

A

swine, products of other animals (zoonosis)

23
Q

II. Yersinia genus - Yersinia enterocoliticaI
15. What is the diagnose for the diseases caused by Yersinia enterocolitica?

A
  • based on clinical signs and symptoms, patient history
  • sampling: stool, blood (for serology)
  • laboratory: culturing of stool, serology from blood (ELISA)
24
Q

II. Yersinia genus - Yersinia enterocoliticaI
16. What is the empirical therapy for the diseases caused by Yersinia enterocolitica?

A
  • supportive therapy in mild cases
  • cephalosporins (3. gen), trimetophrim-sulfamethoxazole, aminoglycosides in blood stream infections
25
Q

II. Yersinia genus - Yersinia pseudotuberculosis
1. What are the features of Yersinia pseudotuberculosis

A

it is probably the ancestor of Yersinia pestis
* they are quite similar genetically!

26
Q

II. Yersinia genus - Yersinia pseudotuberculosis
2. What are the diseases caused by Yersinia pseudotuberculosis ?

A
  • gastroenteritis (diarrhoea)
  • mesenterial lymphadenitis, appendicitis-like symptoms
  • blood stream infection (rarely)
26
Q

II. Yersinia genus - Yersinia pseudotuberculosis
3. How should we diagnosis Yersinia pseudotuberculosis

A
  • based on clinical signs and symptoms, patient history
  • sampling: stool, blood (for serology)
  • laboratory: culturing of stool, serology from blood (ELISA)
27
Q

II. Yersinia genus - Yersinia pseudotuberculosis
4. What is the empirical therapy for Yersinia pseudotuberculosis

A
  • supportive therapy in mild cases
  • cephalosporins(3. gen), trimetophrim-sulfamethoxazole, aminoglycosides in blood stream infections

AA Microbio Semifinal (99 decks)

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