III - A. Virology | 17. Rhabdoviruses Flashcards
I. Nervous system infections
1. What are the viruses that can infect nervous system?
I. Nervous system infections
2. What are the RNA viruses that infect nervous system?
II. Rhabdoviruses - lyssa virus (rabies)
1. What is the genetic material of Rhabdoviruses?
linear ssRNA genome
II. Rhabdoviruses - lyssa virus (rabies)
1. What are the features of Lyssa virus?
- infects warm blooded animals
- only replicates in nervous tissue
II. Rhabdoviruses - lyssa virus (rabies)
2. What is the source of infection of lyssa virus (rabies)?
- infected animal
- infected person
II. Rhabdoviruses - lyssa virus (rabies)
3. What is the route of transmission of lyssa virus (rabies)?
- through bite of the infected animal / person
- through transplantation (cornea)
II. Rhabdoviruses - lyssa virus (rabies)
4. What is the pathomechanism of lyssa virus (rabies)?
- viral replication at the original site of the infection
- enters peripherial nerves, migrates into the CNS
- CNS infection
- reaches the cornea, kidneys, salivary glands through axons
II. Rhabdoviruses - lyssa virus (rabies)
5. What are signs and symptoms of lyssa virus (rabies)?
- incubation period (2-16 weeks))
___ - nausea, vomiting, fever
- itching, burning sensation at bite site
- muscle spasm (pharynx – hydrophobia!)
- paralysis
II. Rhabdoviruses - lyssa virus (rabies)
6. What is the diagnosis of lyssa virus (rabies)?
- virus detection from different tissues
- immunfluoreszcencia - observation of the infection source (animal)
II. Rhabdoviruses - lyssa virus (rabies)
7. What is the therapy for lyssa virus (rabies)?
post-exposition prophylactic vaccination
II. Rhabdoviruses - lyssa virus (rabies)
8. How do we prevent lyssa virus (rabies)?
- vaccination of wild animals (lyssa-glycoprotein embedded in
food) - vaccination of dogs (attenuated virus)
- vaccination of people in certain professions (inactivated virus)
