PreOp Meds: Flumazenil (Reversal) Flashcards

1
Q

What is flumazenil (Romazicon)?

A
  • Competitive antagonist for benzodiazepine receptor. (preventative and reversal)
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2
Q

What metabolizes flumazenil? What are its metabolites?

A
  • CYP450’s
  • No active metabolites
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3
Q

What is the dosing of flumazenil?

A
  • 0.2mg IV titrated to consciousness (repeat 0.1mg q1min til 1mg total)
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4
Q

What is the sedation reversal dose range of flumazenil?

A
  • 0.3 - 0.6 mg
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5
Q

What is the complete reversal dose range of flumazenil?

A
  • 0.5 - 1 mg
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6
Q

If the patient is still unconscious after 0.5 - 1mg of flumazenil has been given, what should be considered?

A
  • Other intoxicants (opioids, EtOH, etc)
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7
Q

What is the duration of flumazenil?

A
  • 30 - 60 min
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8
Q

When is flumazenil contraindicated?

A
  • When needed antiepileptics are being given
  • If it precipitates acute EtOH withdrawal.
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