PreOp Meds: Flumazenil (Reversal) Flashcards
1
Q
What is flumazenil (Romazicon)?
A
- Competitive antagonist for benzodiazepine receptor. (preventative and reversal)
2
Q
What metabolizes flumazenil? What are its metabolites?
A
- CYP450’s
- No active metabolites
3
Q
What is the dosing of flumazenil?
A
- 0.2mg IV titrated to consciousness (repeat 0.1mg q1min til 1mg total)
4
Q
What is the sedation reversal dose range of flumazenil?
A
- 0.3 - 0.6 mg
5
Q
What is the complete reversal dose range of flumazenil?
A
- 0.5 - 1 mg
6
Q
If the patient is still unconscious after 0.5 - 1mg of flumazenil has been given, what should be considered?
A
- Other intoxicants (opioids, EtOH, etc)
7
Q
What is the duration of flumazenil?
A
- 30 - 60 min
8
Q
When is flumazenil contraindicated?
A
- When needed antiepileptics are being given
- If it precipitates acute EtOH withdrawal.