Induction Meds: Opioids Agonist - Morphine

Question 1

What is the dosage of Morphine?

Answer 1

1 - 10 mg IV

S22/28

Question 2

How is Morphine metabolized?
What are the metabolites and their significance?

Answer 2

• Glucuronidation in the liver

metabolites:
- Morphine-6-glucuronide = (5-25%) but is an active anaglesic causing late resp depression.

• Morphine-3-glucuronide (75% to 95%) but inactive

S29

Question 3

What would occur with Morphine overdose in a renal failure patient?

Answer 3

Prolonged ventilatory depression.

Question 4

Morphine tends to relieve _____ type pain more than _____ type pain.

Answer 4

Dull: sharp

S27

Question 5

What is the onset of Morphine?

Answer 5

10 - 20 mins

S28

Question 6

What is the IM and IV peak of Morphine?

Answer 6

IM: 45 to 90 mins

IV: 15-30 mins

S28

Question 7

Morphine is ____ standard with opioids

Answer 7

Gold standard

S27

Question 8

What effects does Morphine have?

Answer 8

• Analgesia
• euphoria
• sedation,
• diminished ability to concentrate
• nausea
• feeling of body warmth
• heaviness of extremities,
• dryness of the mouth
• pruritis.

S27

Question 9

What areas of the body does Morphine relieve?

Answer 9

• visceral
• skeletal muscles
• joints and integumental dull > sharp
• intermittent pain

S27

Question 10

What is the duration of Morphine?

Answer 10

4-5 hours

S28

Question 11

What are the first past effects of Morphine in the liver and lungs?

Answer 11

• PO Hepatic 1st Pass: 25%.
• No first pass uptake in lungs

S28

Question 12

Where does Morphine accumulate rapidly?

Answer 12

• kidneys
• liver
• skeletal muscles

S28

Question 13

What is the elimination 1/2 time of Morphine?

Answer 13

longer with morphine-3-glucuronide

S30

Question 14

Which gender has more analgesic potency and slower speed of offset with Morphine?

Answer 14

Women

S30