PreOp Meds: Histamine Concepts Flashcards
1
Q
What cells release endogenous histamine?
A
- Basophils & Mast cells
2
Q
What physiological mechanisms occur from
general histamine release?
A
- Bronchostriction
- Stomach acid secretion
- CNS neurotransmitter release (ACh, NE, 5HT)
3
Q
What drugs can induce histamine release?
A
- Morphine
- Protamine
- Mivacurium
- Atracurium
4
Q
Are anti-histamine’s competitive antagonists?
A
No, they are inverse agonists.
5
Q
What would be used to treat drug-induced histamine release?
A
- H1 & H2 antagonists
