Induction Meds: Opioids Agonist - Sufentanil Flashcards
1
Q
How much more potent is Sufentanil than Fentanyl?
A
5-12 times more potent.
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1
Q
How much of Sufentanil is subject to first pass effects?
A
60% lung first-pass
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2
Q
How much of Sufentanil is protein bound? What protein is it bound to?
A
92.5% α-1 acid glycoprotein bound.
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3
Q
What is the analgesia dose of Sufentanil?
A
0.1 - 0.4 μg/kg IV
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4
Q
What is the induction dose of sufentanil?
A
18.9 mcg/kg IV
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5
Q
What is the metabolism and excretion of Sufentanil?
A
Metabolism: hepatic
Excretion: renal and fecal (caution in chronic renal failure)
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6
Q
What is the context-sensitive half-time and Vd of Sufentanil?
A
- Context-sensitive half-time: shorter
- larger Vd > alfentanil
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7
Q
What is the intraop dose of Sufentanil?
A
0.3 to 1 µg/kg IV
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8
Q
What is the infusion dose of Sufentanil?
A
0.5 to 1 µg/kg/hr IV
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9
Q
What are the side effects of Sufentanil?
A
- Bradycardia (↓ C.O.)
- Rigidity chest wall and abdominal muscles)
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