Induction Meds: Opioids Agonist - Alfentanil Flashcards
1
Q
What is the potency of Alfentanil?
What is its onset?
A
- 20% as potent as Fentanyl
- Onset: 1.4 min (faster than all derivatives except Remifentanil)
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2
Q
What is the Alfentanil induction dose?
A
Induction: 150 - 300 mcg /kg IV
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3
Q
What drug can cause acute dystonia when given to a Parkinson’s patient?
A
Alfentanil
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4
Q
What is laryngoscopy dose of Alfentanil?
A
15 - 30 mcg/kg IV (90 seconds prior)
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5
Q
What about is the maintenance dose of Alfentanil?
A
25 - 150 mcg/kg/hr with inhaled anesthetics
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6
Q
What are the pharmacokinetics of Alfentanil?
A
- Cirrhosis: prolongs elimination half-time
- 90% nonionized at normal pH –> lower lipid solubility
- Higher protein binding
- Metabolite: Noralfentanil (Hepatic P450 3A4)
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