Induction Meds: Opioids Agonist-Antagonist - Other drugs

Question 1

Which two drugs have resistance to Naloxone?

Answer 1

• Buprenorphine and Bremazocine.

S13 and S14

Question 2

Opioid Agonist-Antagonist

What are drug facts of Nalorphine?

Answer 2

• equally potent with Morphine
• Not used clinically: high incidence of dysphoria (σ receptors)

S14

Question 3

Opioid Agonist-Antagonist

What are drug facts of Bremazocine?

Answer 3

• κ receptors 2x potent > Morphine
• Naloxone = not effective as reversal (could be other receptors)

S14

Question 4

Opioid Agonist-Antagonist

What are drug facts of Decozine?

Answer 4

• δ & µ: analgesia, no CV
• 0.15 mg/kg IM= Morphine
• 10 to 15 mg IM rapid absorption
• Onset: 15 mins.

S14

Question 5

What are drug facts of Meptazinol?

Answer 5

• mu1 receptors
• 100 mg = 8 mg Morphine
  ** Rapid onset
• Duration: < 2 hrs
• Protein binding: 25%

S14