PreOp Meds: PPI concepts Flashcards
1
Q
How do proton pump inhibitors work?
What is the onset of action for proton pump inhibitors?
A
- Irreversible binding to H⁺ pumps preventing acid creation.
- 3-5 days for full result.
2
Q
What is the most effective drug for controlling gastric acidity and volume?
A
- PPI’s
3
Q
For what four conditions are PPI’s indicated?
A
- Esophagitis
- Ulceration
- GERD
- Zollinger-Ellison (excess acid)
4
Q
What coagulation considerations have to be made with PPI’s?
A
- PPI’s inhibit warfarin metabolism = warfarin overdose
- PPI’s block clopidogrel = plavix won’t work.
5
Q
In what situations is an H2 blocker preferred over a PPI?
A
- Aspiration Pneumonitis possibility (H2 blocker works faster)
- Intermittent symptoms
- Cost
6
Q
In what situations are PPI’s superior to H2 blockers?
A
- Any ulcerations
- GERD
- Acute upper GI hemmorhage
7
Q
What five serious conditions have been associated with PPI’s?
A
- Bone fractures
- Lupus
- Acute interstitial nephritis
- C-diff
- Deficient Vit B12 & Mg⁺⁺
