Induction Meds: Opioids Agonist-Antagonist

Question 1

What is the primary indication for opioid agonist-antagonists?

Answer 1

Used if unable to tolerate full agonist

S4

Question 2

Name the four advantages of Opioid Agonist-Antagonists.

Answer 2

• Analgesia
• Less respiratory depression
• Low dependence potential
• Ceiling effect (prevents ODing)

S6

Question 2

Which receptors that Opioid Agonist-Antagonists binds to and their effects?

Answer 2

µ receptors: partial effect (agonist) or no effect (competitive antagonist)

Κ and δ receptors: partial effect (agonist)

S6