Induction Meds: Opioids Agonist - Remifentanil Flashcards
What receptor affinity does Remifentanil have?
How potent is it?
μ opioid agonist that is equipotent to fentanyl
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What is Remifentanil’s structure and why is it important?
Ester Structure = hydrolyzed by plasma & tissue esterases.
- Rapid onset & recovery
- rapid titratable effect
- No accumulation
- rapid recovery when discontinued
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What drug was said to be a great choice for carotid procedures in lecture?
Remifentanil
What is the clearance of Remfentanil?
3-L/min
(8x faster than Alfentanil)
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What is the induction dose of Remifentanil?
0.5 to 1 µg/kg IV over 30-60 seconds
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What is the maintenance dosing of Remifentanil?
- 0.005 - 2 μg/kg/min IV
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What is the peak effect of Remifentanil?
30 - 60 seconds
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Where is Remifentanil excreted?
kidneys
(unchanged by renal or hepatic disease)
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What is the elimination half-time of Remifentanil?
6.3 minutes
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What do you need to give before stopping Remifentanil?
give longer-acting opioid
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What use is not recommended for Remifentanil?
spinal or epidural use
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What are the side effects of Remifentanil?
- Seizure-like activity
- N/V
- Depression of ventilation
- Decreased BP and HR
- Hyperalgesia d/t
-Previous acute exposure to large opioid doses
-Tolerance
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