PreOp Meds: Histamine Concepts Flashcards

1
Q

What cells release endogenous histamine?

A
  • Basophils & Mast cells
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2
Q

What physiological mechanisms occur from
general histamine release?

A
  • Bronchostriction
  • Stomach acid secretion
  • CNS neurotransmitter release (ACh, NE, 5HT)
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3
Q

What drugs can induce histamine release?

A
  • Morphine
  • Protamine
  • Mivacurium
  • Atracurium
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4
Q

Are anti-histamine’s competitive antagonists?

A

No, they are inverse agonists.

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5
Q

What would be used to treat drug-induced histamine release?

A
  • H1 & H2 antagonists
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