PreOp Meds: H1 Antagonist concepts Flashcards

1
Q

Histamine-1 receptor activation can mimic these other receptor types.

A
  • Muscarinic
  • Cholinergic
  • 5HT3
  • α-adrenergic
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2
Q

Histamine binding to H1 receptors generally elicits what effects?

A
  • Hyperalgesia
  • Inflammatory pain (insect stings)
  • Allergic rhino-conjunctivitis s/s
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3
Q

How prone are H1 antagonists to tachyphylaxis?

A
  • Very little tachyphylaxis development
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4
Q

What signs/symptoms occur with excessive H-1 & H-2 activation?

A
  • Hypotension (from NO) release
  • ↑capillary permeability
  • Flushing
  • Prostacyclin release
  • Tachycardia
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5
Q

What are the side effects of H1 antagonists?

A
  • Drowsiness/sedation
  • Blurred vision
  • Urinary retention
  • Dry mouth
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6
Q

What are four examples of H1 receptor antagonists?

A
  • Diphenhydramine (Benadryl)
  • Promethazine (Phenergan)
  • Cetirizine (Zyrtec)
  • Loratidine (Claritin)
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